1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	A	E	P	R	R	G	D	L	W	L	V	S	L	G	A	A	R	A	G	E	P	G	K	H	R	P	A	V	V	V	S	V	D	E	L	L	T	G	I	D	D	E	L	V	V	V	V	P	V	S	S	S	R	S	R	T	P	L	R
Secondary structure
SS confidence
Disorder		?	?	?	?														?	?	?																?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	P	V	A	P	S	E	G	V	A	A	D	S	V	A	V	C	R	G	V	R	A	V	A	R	A	R	L	V	E	R	L	G	A	L	K	P	A	T	M	R	A	I	E	N	A	L	T	L	I	L	G	L	P	T	G	P	E	R	G
Secondary structure
SS confidence
Disorder									?																																															?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.
Sequence		E	A	A	T	H	S	P	V	R	W	T	G	G	R	D	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 24%) Alpha helix ( 18%) Beta strand ( 26%)

Rank Aligned region

PDB 5wyg chain C Region: 1 - 114 Aligned: 106 Modelled: 114 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: C: PDB Molecule:probable endoribonuclease mazf7; PDBTitle: the crystal structure of the apo form of mtb mazf Phyre2 PDB 4mzp chain C Region: 4 - 114 Aligned: 111 Modelled: 111 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: C: PDB Molecule:mazf mrna interferase; PDBTitle: mazf from s. aureus crystal form iii, c2221, 2.7 a Phyre2 PDB 1ne8 chain A Region: 3 - 115 Aligned: 113 Modelled: 113 Confidence: 99.9% Identity: 23% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: Kid/PemK Phyre2 PDB 5hjz chain A Region: 4 - 113 Aligned: 110 Modelled: 110 Confidence: 99.9% Identity: 32% PDB header:hydrolase/rna Chain: A: PDB Molecule:endoribonuclease mazf9; PDBTitle: structure of m. tuberculosis mazf-mt1 (rv2801c) in complex with rna Phyre2 PDB 5xe3 chain B Region: 1 - 116 Aligned: 100 Modelled: 100 Confidence: 99.9% Identity: 26% PDB header:hydrolase/antitoxin Chain: B: PDB Molecule:endoribonuclease mazf4; PDBTitle: endoribonuclease in complex with its cognate antitoxin from2 mycobacterial species Phyre2 PDB 1m1f chain A Region: 4 - 111 Aligned: 105 Modelled: 108 Confidence: 99.9% Identity: 25% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: Kid/PemK Phyre2 PDB 1ub4 chain A Region: 1 - 112 Aligned: 100 Modelled: 112 Confidence: 99.9% Identity: 29% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: Kid/PemK Phyre2 PDB 5hk3 chain B Region: 4 - 113 Aligned: 100 Modelled: 110 Confidence: 99.9% Identity: 19% PDB header:hydrolase/dna Chain: B: PDB Molecule:endoribonuclease mazf6; PDBTitle: crystal structure of m. tuberculosis mazf-mt3 t52d-f62d mutant in2 complex with dna Phyre2 PDB 5cca chain A Region: 24 - 113 Aligned: 88 Modelled: 90 Confidence: 99.8% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:endoribonuclease mazf3; PDBTitle: crystal structure of mtb toxin Phyre2 PDB 3jrz chain A Region: 16 - 111 Aligned: 89 Modelled: 96 Confidence: 95.1% Identity: 17% PDB header:toxin Chain: A: PDB Molecule:ccdb; PDBTitle: ccdbvfi-formii-ph5.6 Phyre2 PDB 3vub chain A Region: 23 - 111 Aligned: 85 Modelled: 89 Confidence: 93.0% Identity: 18% Fold: SH3-like barrel Superfamily: Cell growth inhibitor/plasmid maintenance toxic component Family: CcdB Phyre2 PDB 5ikj chain A Region: 2 - 37 Aligned: 29 Modelled: 36 Confidence: 43.1% Identity: 17% PDB header:transcription Chain: A: PDB Molecule:cryptic loci regulator 2; PDBTitle: structure of clr2 bound to the clr1 c-terminus Phyre2 PDB 4ijr chain A Region: 95 - 135 Aligned: 37 Modelled: 41 Confidence: 37.6% Identity: 11% PDB header:oxidoreductase Chain: A: PDB Molecule:d-arabinose dehydrogenase [nad(p)+] heavy chain; PDBTitle: crystal structure of saccharomyces cerevisiae arabinose dehydrogenase2 ara1 complexed with nadph Phyre2 PDB 4bed chain A Region: 55 - 110 Aligned: 56 Modelled: 56 Confidence: 33.6% Identity: 21% PDB header:oxygen transport Chain: A: PDB Molecule:hemocyanin klh1; PDBTitle: keyhole limpet hemocyanin (klh): 9a cryoem structure and molecular2 model of the klh1 didecamer reveal the interfaces and intricate3 topology of the 160 functional units Phyre2 PDB 2l89 chain A Region: 2 - 112 Aligned: 92 Modelled: 111 Confidence: 32.6% Identity: 16% PDB header:protein binding Chain: A: PDB Molecule:pwwp domain-containing protein 1; PDBTitle: solution structure of pdp1 pwwp domain reveals its unique binding2 sites for methylated h4k20 and dna Phyre2 PDB 4me8 chain A Region: 1 - 15 Aligned: 15 Modelled: 15 Confidence: 23.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:signal peptidase i; PDBTitle: crystal structure of a signal peptidase i (ef3073) from enterococcus2 faecalis v583 at 2.27 a resolution Phyre2 PDB 3llr chain A Region: 2 - 110 Aligned: 87 Modelled: 96 Confidence: 15.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:dna (cytosine-5)-methyltransferase 3a; PDBTitle: crystal structure of the pwwp domain of human dna (cytosine-5-)-2 methyltransferase 3 alpha Phyre2 PDB 5vc8 chain B Region: 1 - 110 Aligned: 95 Modelled: 110 Confidence: 14.4% Identity: 12% PDB header:dna binding protein Chain: B: PDB Molecule:histone-lysine n-methyltransferase nsd2; PDBTitle: crystal structure of the whsc1 pwwp1 domain Phyre2 PDB 2zkr chain T Region: 4 - 91 Aligned: 72 Modelled: 79 Confidence: 13.8% Identity: 21% PDB header:ribosomal protein/rna Chain: T: PDB Molecule:rna expansion segment es39 part iii; PDBTitle: structure of a mammalian ribosomal 60s subunit within an 80s complex2 obtained by docking homology models of the rna and proteins into an3 8.7 a cryo-em map Phyre2 PDB 3mxu chain A Region: 7 - 44 Aligned: 37 Modelled: 38 Confidence: 12.5% Identity: 24% PDB header:oxidoreductase Chain: A: PDB Molecule:glycine cleavage system h protein; PDBTitle: crystal structure of glycine cleavage system protein h from bartonella2 henselae Phyre2 1 c5wygC_ 2 c4mzpC_ 3 d1ne8a_ 4 c5hjzA_ 5 c5xe3B_ 6 d1m1fa_ 7 d1ub4a_ 8 c5hk3B_ 9 c5ccaA_ 10 c3jrzA_ 11 d3vuba_ 12 c5ikjA_ 13 c4ijrA_ 14 c4bedA_ 15 c2l89A_ 16 c4me8A_ 17 c3llrA_ 18 c5vc8B_ 19 c2zkrt_ 20 c3mxuA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45