1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	R	G	T	L	W	G	V	G	L	G	P	G	D	P	E	L	V	T	V	K	A	A	R	V	I	G	E	A	D	V	V	A	Y	H	S	A	P	H	G	H	S	I	A	R	G	I	A	E	P	Y	L	R	P	G	Q	L	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	H	L	V	Y	P	V	T	T	E	A	T	N	H	P	G	G	Y	A	G	A	L	E	D	F	Y	A	D	A	T	E	R	I	A	T	H	L	D	A	G	R	N	V	A	L	L	A	E	G	D	P	L	F	Y	S	S	Y	M	H	L
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	T	R	L	T	R	R	F	N	A	V	I	V	P	G	V	T	S	V	S	A	A	S	A	A	V	A	T	P	L	V	A	G	D	Q	V	L	S	V	L	P	G	T	L	P	V	G	E	L	T	R	R	L	A	D	A	D	A	A	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	V	K	L	G	R	S	Y	H	N	V	R	E	A	L	S	A	S	G	L	L	G	D	A	F	Y	V	E	R	A	S	T	A	G	Q	R	V	L	P	A	A	D	V	D	E	T	S	V	P	Y	F	S	L	A	M	L	P	G	G	R
Secondary structure
SS confidence
Disorder																																												?	?													?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	R	A	L	L	T	G	T	V	A	V	V	G	L	G	P	G	D	S	D	W	M	T	P	Q	S	R	R	E	L	A	A	A	T	D	L	I	G	Y	R	G	Y	L	D	R	V	E	V	R	D	G	Q	R	R	H	P	S	D	N	T
Secondary structure
SS confidence
Disorder		?	?	?	?																																														?								?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	E	P	A	R	A	R	L	A	C	S	L	A	D	Q	G	R	A	V	A	V	V	S	S	G	D	P	G	V	F	A	M	A	T	A	V	L	E	E	A	E	Q	W	P	G	V	R	V	R	V	I	P	A	M	T	A	A	Q	A	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	S	R	V	G	A	P	L	G	H	D	Y	A	V	I	S	L	S	D	R	L	K	P	W	D	V	I	A	A	R	L	T	A	A	A	A	A	D	L	V	L	A	I	Y	N	P	A	S	V	T	R	T	W	Q	V	G	A	M	R	E
Secondary structure
SS confidence
Disorder																						?	?	?																								?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	L	L	A	H	R	D	P	G	I	P	V	V	I	G	R	N	V	S	G	P	V	S	G	P	N	E	D	V	R	V	V	K	L	A	D	L	N	P	A	E	I	D	M	R	C	L	L	I	V	G	S	S	Q	T	R	W	Y	S	V
Secondary structure
SS confidence
Disorder																																								?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.
Sequence		D	S	Q	D	R	V	F	T	P	R	R	Y	P	E	A	G	R	A	T	A	T	K	S	S	R	H	S	D
Secondary structure
SS confidence
Disorder		?	?	?												?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 34%) Beta strand ( 23%)

Rank Aligned region

PDB 3nut chain C Region: 245 - 491 Aligned: 239 Modelled: 247 Confidence: 100.0% Identity: 44% PDB header:transferase Chain: C: PDB Molecule:precorrin-3 methylase; PDBTitle: crystal structure of the methyltransferase cobj Phyre2 PDB 2zvb chain A Region: 247 - 491 Aligned: 237 Modelled: 245 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: A: PDB Molecule:precorrin-3 c17-methyltransferase; PDBTitle: crystal structure of tt0207 from thermus thermophilus hb8 Phyre2 PDB 2e0k chain A Region: 1 - 246 Aligned: 232 Modelled: 246 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:precorrin-2 c20-methyltransferase; PDBTitle: crystal structure of cbil, a methyltransferase involved in anaerobic2 vitamin b12 biosynthesis Phyre2 PDB 1pjt chain B Region: 241 - 481 Aligned: 232 Modelled: 241 Confidence: 100.0% Identity: 22% PDB header:transferase/oxidoreductase/lyase Chain: B: PDB Molecule:siroheme synthase; PDBTitle: the structure of the ser128ala point-mutant variant of cysg, the2 multifunctional methyltransferase/dehydrogenase/ferrochelatase for3 siroheme synthesis Phyre2 PDB 2ybo chain A Region: 245 - 490 Aligned: 233 Modelled: 246 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:methyltransferase; PDBTitle: the x-ray structure of the sam-dependent uroporphyrinogen2 iii methyltransferase nire from pseudomonas aeruginosa in3 complex with sah Phyre2 PDB 2qbu chain A Region: 4 - 236 Aligned: 220 Modelled: 233 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:precorrin-2 methyltransferase; PDBTitle: crystal structure of methanothermobacter thermautotrophicus cbil Phyre2 PDB 1s4d chain A Region: 243 - 489 Aligned: 235 Modelled: 247 Confidence: 100.0% Identity: 20% Fold: Tetrapyrrole methylase Superfamily: Tetrapyrrole methylase Family: Tetrapyrrole methylase Phyre2 PDB 1cbf chain A Region: 239 - 473 Aligned: 225 Modelled: 235 Confidence: 100.0% Identity: 20% Fold: Tetrapyrrole methylase Superfamily: Tetrapyrrole methylase Family: Tetrapyrrole methylase Phyre2 PDB 1cbf chain A Region: 239 - 473 Aligned: 225 Modelled: 235 Confidence: 100.0% Identity: 20% PDB header:methyltransferase Chain: A: PDB Molecule:cobalt-precorrin-4 transmethylase; PDBTitle: the x-ray structure of a cobalamin biosynthetic enzyme, cobalt2 precorrin-4 methyltransferase, cbif Phyre2 PDB 1pjq chain A domain 2 Region: 247 - 481 Aligned: 221 Modelled: 235 Confidence: 100.0% Identity: 23% Fold: Tetrapyrrole methylase Superfamily: Tetrapyrrole methylase Family: Tetrapyrrole methylase Phyre2 PDB 3kwp chain A Region: 245 - 474 Aligned: 217 Modelled: 230 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:predicted methyltransferase; PDBTitle: crystal structure of putative methyltransferase from lactobacillus2 brevis Phyre2 PDB 3ndc chain B Region: 248 - 475 Aligned: 215 Modelled: 228 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:precorrin-4 c(11)-methyltransferase; PDBTitle: crystal structure of precorrin-4 c11-methyltransferase from2 rhodobacter capsulatus Phyre2 PDB 4e16 chain A Region: 247 - 473 Aligned: 218 Modelled: 227 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:precorrin-4 c(11)-methyltransferase; PDBTitle: precorrin-4 c(11)-methyltransferase from clostridium difficile Phyre2 PDB 1ve2 chain A domain 1 Region: 245 - 481 Aligned: 214 Modelled: 237 Confidence: 100.0% Identity: 26% Fold: Tetrapyrrole methylase Superfamily: Tetrapyrrole methylase Family: Tetrapyrrole methylase Phyre2 PDB 1va0 chain A domain 1 Region: 247 - 471 Aligned: 211 Modelled: 225 Confidence: 100.0% Identity: 26% Fold: Tetrapyrrole methylase Superfamily: Tetrapyrrole methylase Family: Tetrapyrrole methylase Phyre2 PDB 5hw4 chain C Region: 247 - 472 Aligned: 212 Modelled: 221 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: C: PDB Molecule:ribosomal rna small subunit methyltransferase i; PDBTitle: crystal structure of escherichia coli 16s rrna methyltransferase rsmi2 in complex with adomet Phyre2 PDB 3nd1 chain B Region: 5 - 226 Aligned: 213 Modelled: 222 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: B: PDB Molecule:precorrin-6a synthase/cobf protein; PDBTitle: crystal structure of precorrin-6a synthase from rhodobacter capsulatus Phyre2 PDB 1wyz chain A domain 1 Region: 247 - 471 Aligned: 209 Modelled: 220 Confidence: 100.0% Identity: 13% Fold: Tetrapyrrole methylase Superfamily: Tetrapyrrole methylase Family: Tetrapyrrole methylase Phyre2 PDB 2npn chain A Region: 6 - 219 Aligned: 196 Modelled: 214 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:putative cobalamin synthesis related protein; PDBTitle: crystal structure of putative cobalamin synthesis related protein2 (cobf) from corynebacterium diphtheriae Phyre2 PDB 2dek chain A domain 1 Region: 248 - 472 Aligned: 219 Modelled: 225 Confidence: 100.0% Identity: 18% Fold: Tetrapyrrole methylase Superfamily: Tetrapyrrole methylase Family: Tetrapyrrole methylase Phyre2 1 c3nutC_ 2 c2zvbA_ 3 c2e0kA_ 4 c1pjtB_ 5 c2yboA_ 6 c2qbuA_ 7 d1s4da_ 8 d1cbfa_ 9 c1cbfA_ 10 d1pjqa2 11 c3kwpA_ 12 c3ndcB_ 13 c4e16A_ 14 d1ve2a1 15 d1va0a1 16 c5hw4C_ 17 c3nd1B_ 18 d1wyza1 19 c2npnA_ 20 d2deka1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99