1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	R	A	R	W	L	Q	S	A	A	L	M	G	A	L	A	V	V	L	I	T	A	A	P	V	A	A	D	A	Y	Q	V	P	A	P	P	S	P	T	A	S	C	D	V	I	S	P	V	A	I	P	C	V	A	L	G	K	F	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?												?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?		?		?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	A	V	A	A	E	C	R	R	V	G	V	P	D	A	R	C	V	L	P	L	A	H	R	V	T	Q	A	A	R	D	A	Y	L	Q	S	W	V	H	R	T	A	R	F	Q	D	A	L	Q	D	P	V	P	L	R	E	T	Q	W	L
Secondary structure
SS confidence
Disorder		?	?												?	?		?	?	?	?	?	?	?							?	?																?	?	?		?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	T	H	N	S	F	N	S	L	S	D	S	F	T	V	S	H	A	D	S	N	Q	Q	L	S	L	A	Q	Q	L	D	I	D	V	R	A	L	E	L	D	L	H	Y	L	P	R	L	E	G	H	G	A	P	G	V	T	V	C	H	G
Secondary structure
SS confidence
Disorder											?		?																																		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	G	P	K	N	A	N	L	G	C	T	V	E	P	L	L	A	T	V	L	P	Q	I	A	N	W	L	N	A	P	G	H	T	E	E	V	I	L	L	Y	L	E	D	Q	L	K	N	A	S	A	Y	E	S	V	V	A	T	L	D	Q
Secondary structure
SS confidence
Disorder																																												?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	L	R	R	A	D	G	T	S	L	I	Y	R	P	N	P	A	R	R	A	T	N	G	C	V	P	L	P	L	D	V	S	R	E	E	I	R	A	S	G	A	R	A	V	L	V	G	S	C	A	P	G	W	S	A	A	V	F	D	W
Secondary structure
SS confidence
Disorder									?							?	?	?	?	?	?	?										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	G	V	E	L	E	S	G	S	N	S	G	Y	R	P	Y	P	A	C	D	A	T	Y	G	R	G	V	Y	A	W	R	L	V	R	Y	Y	E	D	S	T	L	A	T	A	L	A	N	P	T	R	P	P	A	N	P	Q	A	L	T	P
Secondary structure
SS confidence
Disorder												?																															?					?	?	?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		P	K	V	P	A	M	T	D	C	G	V	N	L	F	G	F	D	Q	L	L	P	E	D	G	R	I	Q	A	S	L	W	S	W	A	P	D	E	P	R	A	G	A	G	A	C	A	L	Q	G	A	D	G	R	W	V	A	A	S	C	G
Secondary structure
SS confidence
Disorder																						?																		?	?	?																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		D	P	H	P	A	A	C	R	D	A	A	G	R	W	T	V	T	P	A	P	V	V	F	A	G	A	A	L	A	C	T	A	I	G	A	D	F	T	L	P	R	T	G	N	Q	N	A	R	L	H	A	V	A	G	P	A	G	G	A	W
Secondary structure
SS confidence
Disorder																					?		?	?	?			?														?	?											?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.
Sequence		V	H	Y	L	L	P	P
Secondary structure
SS confidence
Disorder							?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 23%) Beta strand ( 15%)

Rank Aligned region

PDB 3h4w chain A Region: 113 - 286 Aligned: 147 Modelled: 174 Confidence: 99.9% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:phosphatidylinositol-specific phospholipase c1; PDBTitle: structure of a ca+2 dependent phosphatidylinositol-specific2 phospholipase c (pi-plc) enzyme from streptomyces antibioticus Phyre2 PDB 2ptd chain A Region: 107 - 302 Aligned: 163 Modelled: 196 Confidence: 99.9% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: PLC-like phosphodiesterases Family: Bacterial PLC Phyre2 PDB 2plc chain A Region: 107 - 291 Aligned: 151 Modelled: 185 Confidence: 99.9% Identity: 25% Fold: TIM beta/alpha-barrel Superfamily: PLC-like phosphodiesterases Family: Bacterial PLC Phyre2 PDB 3v18 chain A Region: 107 - 285 Aligned: 150 Modelled: 179 Confidence: 99.8% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:1-phosphatidylinositol phosphodiesterase; PDBTitle: structure of the phosphatidylinositol-specific phospholipase c from2 staphylococcus aureus Phyre2 PDB 5fyo chain A Region: 110 - 280 Aligned: 149 Modelled: 159 Confidence: 99.5% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:phosphoinositol-specific phospholipase c; PDBTitle: calcium-dependent phosphoinositol-specific phospholipase c from a2 gram-negative bacterium, pseudomonas sp, apo form, crystal form 1 Phyre2 PDB 2zkm chain X domain 4 Region: 109 - 268 Aligned: 137 Modelled: 160 Confidence: 98.2% Identity: 18% Fold: TIM beta/alpha-barrel Superfamily: PLC-like phosphodiesterases Family: Mammalian PLC Phyre2 PDB 1qas chain A domain 3 Region: 111 - 271 Aligned: 133 Modelled: 161 Confidence: 98.2% Identity: 24% Fold: TIM beta/alpha-barrel Superfamily: PLC-like phosphodiesterases Family: Mammalian PLC Phyre2 PDB 1djy chain B Region: 109 - 271 Aligned: 128 Modelled: 149 Confidence: 98.0% Identity: 24% PDB header:lipid degradation Chain: B: PDB Molecule:phosphoinositide-specific phospholipase c, PDBTitle: phosphoinositide-specific phospholipase c-delta1 from rat2 complexed with inositol-2,4,5-trisphosphate Phyre2 PDB 3ohm chain B Region: 109 - 268 Aligned: 137 Modelled: 156 Confidence: 97.9% Identity: 20% PDB header:signaling protein / hydrolase Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3 Phyre2 PDB 3qr0 chain A Region: 109 - 271 Aligned: 138 Modelled: 163 Confidence: 97.8% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:phospholipase c-beta (plc-beta); PDBTitle: crystal structure of s. officinalis plc21 Phyre2 PDB 2fju chain B Region: 109 - 268 Aligned: 137 Modelled: 160 Confidence: 97.7% Identity: 18% PDB header:signaling protein,apoptosis/hydrolase Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: activated rac1 bound to its effector phospholipase c beta 2 Phyre2 PDB 5xtw chain H Region: 393 - 481 Aligned: 89 Modelled: 89 Confidence: 97.1% Identity: 19% PDB header:sugar binding protein Chain: H: PDB Molecule:macrophage mannose receptor 1; PDBTitle: crystal structure of the cysr-ctld2 fragment of human mr at acidic ph Phyre2 PDB 5e4l chain B Region: 393 - 428 Aligned: 36 Modelled: 36 Confidence: 96.7% Identity: 28% PDB header:sugar binding protein Chain: B: PDB Molecule:c-type mannose receptor 2; PDBTitle: structure of ligand binding region of uparap at ph 5.3 Phyre2 PDB 5ao6 chain A Region: 393 - 481 Aligned: 89 Modelled: 89 Confidence: 96.7% Identity: 16% PDB header:endocytosis Chain: A: PDB Molecule:c-type mannose receptor 2; PDBTitle: endo180 d1-4, trigonal form Phyre2 PDB 1h8u chain A Region: 391 - 428 Aligned: 38 Modelled: 38 Confidence: 96.6% Identity: 34% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 1hup chain A domain 1 Region: 391 - 428 Aligned: 38 Modelled: 38 Confidence: 95.9% Identity: 29% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 1r13 chain A domain 1 Region: 391 - 428 Aligned: 38 Modelled: 38 Confidence: 95.7% Identity: 34% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: C-type lectin domain Phyre2 PDB 6jli chain A Region: 393 - 428 Aligned: 35 Modelled: 36 Confidence: 95.7% Identity: 29% PDB header:immune system Chain: A: PDB Molecule:secretory phospholipase a2 receptor; PDBTitle: crystal structure of ctld7 domain of human pla2r Phyre2 PDB 3wbr chain C Region: 391 - 428 Aligned: 38 Modelled: 38 Confidence: 95.6% Identity: 24% PDB header:carbohydrate binding protein Chain: C: PDB Molecule:c-type lectin domain family 4 member c; PDBTitle: crystal structure of carbohydrate recognition domain of blood2 dendritic cell antigen-2 (bdca2) lectin (crystal form-3) Phyre2 PDB 1kww chain C Region: 391 - 428 Aligned: 38 Modelled: 38 Confidence: 95.5% Identity: 24% PDB header:immune system, sugar binding protein Chain: C: PDB Molecule:mannose-binding protein a; PDBTitle: rat mannose protein a complexed with a-me-fuc. Phyre2 1 c3h4wA_ 2 d2ptda_ 3 d2plca_ 4 c3v18A_ 5 c5fyoA_ 6 d2zkmx4 7 d1qasa3 8 c1djyB_ 9 c3ohmB_ 10 c3qr0A_ 11 c2fjuB_ 12 c5xtwH_ 13 c5e4lB_ 14 c5ao6A_ 15 d1h8ua_ 16 d1hupa1 17 d1r13a1 18 c6jliA_ 19 c3wbrC_ 20 c1kwwC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191