1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	L	R	H	I	N	I	R	A	L	I	A	E	A	G	G	D	P	W	A	I	E	H	S	L	H	A	G	R	P	A	Q	I	A	E	L	A	E	A	F	H	A	A	G	R	Y	T	A	E	A	N	A	A	F	E	E	A	R	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																	?	?	?	?	?	?	?	?	?	?											?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	F	E	A	S	W	N	R	E	N	G	E	H	P	I	N	D	S	A	E	V	Q	R	V	T	A	A	L	G	V	Q	S	L	Q	L	P	K	I	G	V	D	L	E	N	I	A	A	D	L	A	E	A	Q	R	A	A	A	G	R	I
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	T	L	E	S	Q	L	Q	R	I	D	D	Q	L	D	Q	A	L	E	L	E	H	D	P	R	L	A	A	A	E	R	S	E	L	D	A	L	I	T	C	L	E	Q	D	A	I	D	D	T	A	S	A	L	G	Q	L	Q	S	I	R
Secondary structure
SS confidence
Disorder										?	?	?	?							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	G	Y	S	D	H	L	Q	Q	S	L	A	M	L	R	A	D	G	Y	D	G	A	G	L	Q	G	L	D	A	P	Q	S	P	V	K	P	E	E	P	I	Q	I	P	P	P	G	T	G	A	P	E	V	H	R	W	W	T	S	L	T
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	E	E	R	Q	R	L	I	A	E	H	P	E	Q	I	G	N	L	N	G	V	P	V	S	A	R	S	D	A	N	I	A	V	M	T	R	D	L	N	R	V	R	D	I	A	T	R	Y	R	T	S	V	D	D	V	L	G	D	P	A
Secondary structure
SS confidence
Disorder																?																																							?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	Y	G	L	S	A	G	D	I	T	R	Y	R	N	A	D	E	T	K	K	G	L	D	H	N	A	R	N	D	P	R	N	P	S	P	V	Y	L	F	A	Y	D	P	M	A	F	G	G	K	G	R	A	A	I	A	I	G	N	P	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?																				?	?	?	?	?	?	?	?	?	?									?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		T	A	K	H	T	A	V	I	V	P	G	T	S	S	S	V	K	G	G	W	L	H	D	N	H	D	D	A	L	N	L	F	N	Q	A	K	A	A	D	P	N	N	P	T	A	V	I	A	W	M	G	Y	D	A	P	N	D	F	T	D
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?	?											?	?	?	?	?	?																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	R	I	A	T	P	M	L	A	R	I	G	G	A	A	L	A	E	D	V	N	G	L	W	V	T	H	L	G	V	G	Q	N	V	T	V	L	G	H	S	Y	G	S	T	T	V	A	D	A	F	A	L	G	G	M	H	A	N	D	A
Secondary structure
SS confidence
Disorder		?	?	?		?	?																																															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		V	L	L	G	C	P	G	T	D	L	A	H	S	A	A	S	F	H	L	D	G	G	R	V	Y	V	G	A	A	S	T	D	P	I	S	M	L	G	Q	L	D	S	L	S	Q	Y	V	N	R	G	N	L	A	G	Q	L	Q	G	L	A
Secondary structure
SS confidence
Disorder												?	?	?					?	?																						?	?		?	?	?	?	?	?	?	?	?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		V	G	L	G	T	D	P	A	G	D	G	F	G	S	V	R	F	R	A	E	V	P	N	S	D	G	I	N	P	H	D	H	S	Y	Y	Y	H	R	G	S	E	A	L	R	S	M	A	D	I	A	S	G	H	G	D	A	L	A	S	D
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?	?	?	?	?					?																			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.
Sequence		G	M	L	A	Q	P	R	H	Q	P	G	V	E	I	D	I	P	G	L	G	S	V	E	I	D	I	P	G	T	P	A	S	I	D	P	E	W	S	R	P	P	G	S	I	T	D	D	H	V	F	D	A	P	L	H	R
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?		?	?	?	?	?	?	?	?											?		?	?	?	?	?		?		?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 33%) Alpha helix ( 47%) Beta strand ( 8%)

Rank Aligned region

PDB 1tca chain A Region: 359 - 486 Aligned: 105 Modelled: 128 Confidence: 97.6% Identity: 11% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Fungal lipases Phyre2 PDB 3icv chain A Region: 367 - 486 Aligned: 97 Modelled: 120 Confidence: 97.4% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:lipase b; PDBTitle: structural consequences of a circular permutation on lipase b from2 candida antartica Phyre2 PDB 1tia chain A Region: 427 - 576 Aligned: 140 Modelled: 150 Confidence: 97.2% Identity: 15% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Fungal lipases Phyre2 PDB 1ei9 chain A Region: 367 - 490 Aligned: 110 Modelled: 117 Confidence: 97.1% Identity: 10% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Thioesterases Phyre2 PDB 1cex chain A Region: 362 - 514 Aligned: 142 Modelled: 153 Confidence: 97.0% Identity: 14% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Cutinase-like Phyre2 PDB 3gbs chain A Region: 362 - 514 Aligned: 142 Modelled: 153 Confidence: 97.0% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:cutinase 1; PDBTitle: crystal structure of aspergillus oryzae cutinase Phyre2 PDB 5xk2 chain A Region: 427 - 580 Aligned: 144 Modelled: 154 Confidence: 96.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:diacylglycerol lipase; PDBTitle: crystal structure of mono- and diacylglycerol lipase from aspergillus2 oryzae Phyre2 PDB 4gw3 chain A Region: 367 - 489 Aligned: 101 Modelled: 113 Confidence: 96.9% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:putative lipase; PDBTitle: crystal structure of the lipase from proteus mirabilis Phyre2 PDB 1isp chain A Region: 363 - 514 Aligned: 129 Modelled: 152 Confidence: 96.9% Identity: 15% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Bacterial lipase Phyre2 PDB 1ex9 chain A Region: 363 - 489 Aligned: 105 Modelled: 127 Confidence: 96.9% Identity: 20% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Bacterial lipase Phyre2 PDB 4psd chain A Region: 407 - 593 Aligned: 130 Modelled: 140 Confidence: 96.9% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:carbohydrate esterase family 5; PDBTitle: structure of trichoderma reesei cutinase native form. Phyre2 PDB 5x88 chain A Region: 362 - 514 Aligned: 142 Modelled: 153 Confidence: 96.8% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:cutinase; PDBTitle: a crystal structure of cutinases from malbranchea cinnamomea Phyre2 PDB 1cvl chain A Region: 367 - 486 Aligned: 102 Modelled: 109 Confidence: 96.8% Identity: 18% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Bacterial lipase Phyre2 PDB 3bdv chain B Region: 367 - 514 Aligned: 116 Modelled: 129 Confidence: 96.7% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:uncharacterized protein duf1234; PDBTitle: crystal structure of a putative yden-like hydrolase (eca3091) from2 pectobacterium atrosepticum scri1043 at 1.66 a resolution Phyre2 PDB 3lp5 chain A Region: 367 - 486 Aligned: 110 Modelled: 120 Confidence: 96.6% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:putative cell surface hydrolase; PDBTitle: the crystal structure of the putative cell surface hydrolase from2 lactobacillus plantarum wcfs1 Phyre2 PDB 2vav chain L Region: 352 - 487 Aligned: 125 Modelled: 136 Confidence: 96.6% Identity: 12% PDB header:transferase Chain: L: PDB Molecule:acetyl-coa--deacetylcephalosporin c acetyltransferase; PDBTitle: crystal structure of deacetylcephalosporin c acetyltransferase (dac-2 soak) Phyre2 PDB 1gpl chain A Region: 358 - 535 Aligned: 165 Modelled: 178 Confidence: 96.6% Identity: 21% PDB header:serine esterase Chain: A: PDB Molecule:rp2 lipase; PDBTitle: rp2 lipase Phyre2 PDB 1bu8 chain A domain 2 Region: 358 - 535 Aligned: 165 Modelled: 178 Confidence: 96.5% Identity: 22% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Pancreatic lipase, N-terminal domain Phyre2 PDB 2yij chain A Region: 432 - 521 Aligned: 89 Modelled: 90 Confidence: 96.5% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:phospholipase a1-iigamma; PDBTitle: crystal structure of phospholipase a1 Phyre2 PDB 1tib chain A Region: 427 - 576 Aligned: 142 Modelled: 141 Confidence: 96.5% Identity: 17% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Fungal lipases Phyre2 1 d1tcaa_ 2 c3icvA_ 3 d1tiaa_ 4 d1ei9a_ 5 d1cexa_ 6 c3gbsA_ 7 c5xk2A_ 8 c4gw3A_ 9 d1ispa_ 10 d1ex9a_ 11 c4psdA_ 12 c5x88A_ 13 d1cvla_ 14 c3bdvB_ 15 c3lp5A_ 16 c2vavL_ 17 c1gplA_ 18 d1bu8a2 19 c2yijA_ 20 d1tiba_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406