1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	D	D	S	S	S	A	F	D	L	I	C	A	E	I	E	R	Q	L	R	G	G	E	L	L	M	D	A	A	A	A	S	E	L	L	L	T	V	R	Y	Q	L	D	T	Q	P	R	P	L	V	I	V	H	G	P	L	F	Q	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	K	A	A	R	A	Q	V	Y	G	R	L	I	Q	L	R	H	A	R	C	E	V	L	D	E	R	W	Q	L	R	P	T	G	Q	R	D	V	R	A	L	L	I	D	V	L	N	V	L	L	A	A	I	T	A	A	G	V	E	R	A
Secondary structure
SS confidence
Disorder																								?								?	?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	A	C	A	E	R	R	A	M	A	A	A	V	V	A	K	N	Y	R	D	A	L	G	V	E	L	Q	C	N	S	V	C	R	A	A	A	E	A	I	H	A	L	A	H	R	T	G	A	T	E	D	A	D	C	L	P	P	V	D	V
Secondary structure
SS confidence
Disorder																																														?	?			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	H	A	D	V	T	R	R	M	H	G	E	V	A	T	D	V	V	A	A	G	E	L	V	I	A	A	R	H	L	L	D	P	M	P	R	G	E	L	S	Y	G	P	L	H	E	G	G	N	A	A	R	K	S	V	Y	R	R	L	V
Secondary structure
SS confidence
Disorder																						?																									?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	L	W	Q	A	R	R	A	V	T	D	G	D	V	D	L	R	D	A	R	T	L	L	T	D	L	D	S	I	L	R	E	M	R	T	A	A	T	I	Q	Q	S	G	T	A	G	D	G	G	G	G	R	R	Q	D	S	R	R	R	N
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?																									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	P	R	R	P	A	R	R	G	T	S	R	G	R	R	C	A	P	R	V	A	I	G	W	H	T	P	I	G	D	P	L	A	V	E	G	V	E	E	I	G	A	S	L	P	G	R	E	S	T	P	S	D	D	G	G	S	L	H	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																									?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.
Sequence		S	G	R	P	R	R	V	H	R	R	R	W	C	G	L	G	L	C
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?								?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 26%) Alpha helix ( 59%) Beta strand ( 6%)

Rank Aligned region

PDB 1ei9 chain A Region: 45 - 55 Aligned: 11 Modelled: 11 Confidence: 28.2% Identity: 64% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Thioesterases Phyre2 PDB 3iyn chain O Region: 67 - 97 Aligned: 31 Modelled: 31 Confidence: 20.4% Identity: 19% PDB header:virus Chain: O: PDB Molecule:hexon-associated protein; PDBTitle: 3.6-angstrom cryoem structure of human adenovirus type 5 Phyre2 PDB 1cf7 chain B Region: 94 - 111 Aligned: 18 Modelled: 18 Confidence: 19.8% Identity: 44% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Cell cycle transcription factor e2f-dp Phyre2 PDB 4q34 chain A Region: 37 - 55 Aligned: 19 Modelled: 19 Confidence: 17.1% Identity: 47% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative esterase (bdi_1566) from2 parabacteroides distasonis atcc 8503 at 1.60 a resolution Phyre2 PDB 4jmr chain A Region: 214 - 227 Aligned: 14 Modelled: 14 Confidence: 13.4% Identity: 50% PDB header:viral protein/peptide Chain: A: PDB Molecule:gag protein; PDBTitle: a unique spumavirus gag n-terminal domain with functional properties2 of orthoretroviral matrix and capsid Phyre2 PDB 2f5v chain A domain 2 Region: 335 - 362 Aligned: 28 Modelled: 28 Confidence: 12.3% Identity: 32% Fold: FAD-linked reductases, C-terminal domain Superfamily: FAD-linked reductases, C-terminal domain Family: GMC oxidoreductases Phyre2 PDB 1qlw chain A Region: 37 - 55 Aligned: 19 Modelled: 19 Confidence: 11.7% Identity: 42% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: A novel bacterial esterase Phyre2 PDB 4bjj chain B Region: 324 - 334 Aligned: 11 Modelled: 11 Confidence: 11.3% Identity: 55% PDB header:transcription Chain: B: PDB Molecule:transcription factor tau subunit sfc7; PDBTitle: sfc1-sfc7 dimerization module Phyre2 PDB 2vf7 chain B Region: 2 - 20 Aligned: 19 Modelled: 19 Confidence: 11.2% Identity: 42% PDB header:dna binding protein Chain: B: PDB Molecule:excinuclease abc, subunit a.; PDBTitle: crystal structure of uvra2 from deinococcus radiodurans Phyre2 PDB 2lq2 chain A Region: 191 - 200 Aligned: 10 Modelled: 10 Confidence: 10.7% Identity: 80% PDB header:antifreeze protein Chain: A: PDB Molecule:de novo designed antifreeze peptide 4m; PDBTitle: solution structure of de novo designed peptide 4m Phyre2 PDB 3vza chain D Region: 77 - 92 Aligned: 16 Modelled: 16 Confidence: 10.3% Identity: 50% PDB header:cell cycle Chain: D: PDB Molecule:spc24 protein; PDBTitle: crystal structure of the chicken spc24-spc25 globular domain in2 complex with cenp-t peptide Phyre2 PDB 6bi7 chain D Region: 237 - 243 Aligned: 7 Modelled: 7 Confidence: 10.0% Identity: 71% PDB header:replication Chain: D: PDB Molecule:dna polymerase zeta catalytic subunit; PDBTitle: crystal structure of rev7-wt/rev3 as a monomer under high-salt2 conditions Phyre2 PDB 6bc8 chain B Region: 237 - 243 Aligned: 7 Modelled: 7 Confidence: 9.9% Identity: 71% PDB header:replication Chain: B: PDB Molecule:dna polymerase zeta catalytic subunit; PDBTitle: crystal structure of rev7-r124a/rev3-rbm2 (residues 1988-2014) complex Phyre2 PDB 6ekm chain B Region: 237 - 243 Aligned: 7 Modelled: 7 Confidence: 9.9% Identity: 71% PDB header:replication Chain: B: PDB Molecule:dna polymerase zeta catalytic subunit; PDBTitle: crystal structure of mammalian rev7 in complex with human rev3 second2 binding site Phyre2 PDB 6bcd chain B Region: 237 - 243 Aligned: 7 Modelled: 7 Confidence: 9.9% Identity: 71% PDB header:replication Chain: B: PDB Molecule:dna polymerase zeta catalytic subunit; PDBTitle: crystal structure of rev7-k44a/r124a/a135d in complex with rev3-rbm22 (residues 1988-2014) Phyre2 PDB 3zqj chain F Region: 2 - 20 Aligned: 19 Modelled: 19 Confidence: 9.8% Identity: 53% PDB header:dna binding protein Chain: F: PDB Molecule:uvrabc system protein a; PDBTitle: mycobacterium tuberculosis uvra Phyre2 PDB 5nkm chain E Region: 311 - 344 Aligned: 31 Modelled: 34 Confidence: 9.3% Identity: 32% PDB header:rna binding protein Chain: E: PDB Molecule:protein smg-8; PDBTitle: smg8-smg9 complex Phyre2 PDB 1r5q chain A Region: 74 - 108 Aligned: 35 Modelled: 35 Confidence: 8.4% Identity: 37% Fold: KaiA/RbsU domain Superfamily: KaiA/RbsU domain Family: Circadian clock protein KaiA, C-terminal domain Phyre2 PDB 2fz0 chain A Region: 221 - 240 Aligned: 20 Modelled: 20 Confidence: 8.2% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:v-snare component of the vacuolar snare complex PDBTitle: identification of yeast r-snare nyv1p as a novel longin2 domain protein Phyre2 PDB 3pih chain A Region: 2 - 20 Aligned: 19 Modelled: 19 Confidence: 7.9% Identity: 47% PDB header:hydrolase/dna Chain: A: PDB Molecule:uvrabc system protein a; PDBTitle: t. maritima uvra in complex with fluorescein-modified dna Phyre2 1 d1ei9a_ 2 c3iynO_ 3 d1cf7b_ 4 c4q34A_ 5 c4jmrA_ 6 d2f5va2 7 d1qlwa_ 8 c4bjjB_ 9 c2vf7B_ 10 c2lq2A_ 11 c3vzaD_ 12 c6bi7D_ 13 c6bc8B_ 14 c6ekmB_ 15 c6bcdB_ 16 c3zqjF_ 17 c5nkmE_ 18 d1r5qa_ 19 c2fz0A_ 20 c3pihA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38