1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	G	S	R	R	F	D	A	E	V	Y	A	R	R	L	A	L	A	A	A	A	T	A	D	A	G	L	A	G	L	V	I	T	P	G	Y	D	L	C	Y	L	I	G	S	R	A	E	T	F	E	R	L	T	A	L	V	L	P	A	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	A	P	A	V	V	L	P	R	L	E	L	A	A	L	K	Q	S	A	A	A	E	L	G	L	R	V	C	D	W	V	D	G	D	D	P	Y	G	L	V	S	A	V	L	G	G	A	P	V	A	T	A	V	T	D	S	M	P	A	L
Secondary structure
SS confidence
Disorder																																																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	M	L	P	L	A	D	A	L	G	V	L	P	V	L	A	T	D	V	L	R	R	L	R	M	V	K	E	E	T	E	I	D	A	L	R	K	A	G	A	A	I	D	R	V	H	A	R	V	P	E	F	L	V	P	G	R	T	E	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	V	A	A	D	I	A	E	A	I	V	A	E	G	H	S	E	V	A	F	V	I	V	G	S	G	P	H	G	A	D	P	H	H	G	Y	S	D	R	E	L	R	E	G	D	I	V	V	V	D	I	G	G	T	Y	G	P	G	Y	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	D	S	T	R	T	Y	S	I	G	E	P	D	S	D	V	A	Q	S	Y	S	M	L	Q	R	A	Q	R	A	A	F	E	A	I	R	P	G	V	T	A	E	Q	V	D	A	A	A	R	D	V	L	A	E	A	G	L	A	E	Y	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	H	R	T	G	H	G	I	G	L	C	V	H	E	E	P	Y	I	V	A	G	N	D	L	V	L	V	P	G	M	A	F	S	I	E	P	G	I	Y	F	P	G	R	W	G	A	R	I	E	D	I	V	I	V	T	E	D	G	A	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.
Sequence		S	V	N	N	C	P	H	E	L	I	V	V	P	V	S
Secondary structure
SS confidence
Disorder															?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 3%) Alpha helix ( 37%) Beta strand ( 23%) TM helix ( 5%) (View membrane topology prediction)

Rank Aligned region

PDB 4ege chain A Region: 5 - 374 Aligned: 370 Modelled: 370 Confidence: 100.0% Identity: 85% PDB header:hydrolase Chain: A: PDB Molecule:dipeptidase pepe; PDBTitle: crystal structure of dipeptidase pepe from mycobacterium ulcerans Phyre2 PDB 4r60 chain A Region: 5 - 369 Aligned: 362 Modelled: 365 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: A: PDB Molecule:proline dipeptidase; PDBTitle: crystal structure of xaa-pro dipeptidase from xanthomonas campestris Phyre2 PDB 1chm chain A Region: 3 - 369 Aligned: 364 Modelled: 367 Confidence: 100.0% Identity: 23% PDB header:creatinase Chain: A: PDB Molecule:creatine amidinohydrolase; PDBTitle: enzymatic mechanism of creatine amidinohydrolase as deduced2 from crystal structures Phyre2 PDB 4fkc chain A Region: 4 - 372 Aligned: 366 Modelled: 369 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: A: PDB Molecule:xaa-pro aminopeptidase; PDBTitle: recombinant prolidase from thermococcus sibiricus Phyre2 PDB 4zng chain A Region: 13 - 371 Aligned: 355 Modelled: 359 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: A: PDB Molecule:prolidase; PDBTitle: x-ray crystallography of recombinant lactococcus lactis prolidase Phyre2 PDB 2how chain B Region: 14 - 372 Aligned: 354 Modelled: 359 Confidence: 100.0% Identity: 34% PDB header:hydrolase Chain: B: PDB Molecule:356aa long hypothetical dipeptidase; PDBTitle: dipeptidase (ph0974) from pyrococcus horikoshii ot3 Phyre2 PDB 1wy2 chain B Region: 13 - 370 Aligned: 344 Modelled: 358 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: B: PDB Molecule:xaa-pro dipeptidase; PDBTitle: crystal structure of the prolidase from pyrococcus horikoshii ot3 Phyre2 PDB 5cnx chain B Region: 13 - 372 Aligned: 351 Modelled: 360 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: B: PDB Molecule:aminopeptidase ypdf; PDBTitle: crystal structure of xaa-pro aminopeptidase from escherichia coli k12 Phyre2 PDB 3q6d chain A Region: 13 - 372 Aligned: 349 Modelled: 360 Confidence: 100.0% Identity: 30% PDB header:viral protein Chain: A: PDB Molecule:proline dipeptidase; PDBTitle: xaa-pro dipeptidase from bacillus anthracis. Phyre2 PDB 5cdl chain A Region: 13 - 370 Aligned: 348 Modelled: 358 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:proline dipeptidase; PDBTitle: proline dipeptidase from deinococcus radiodurans (selenomethionine2 derivative) Phyre2 PDB 5wze chain C Region: 1 - 369 Aligned: 362 Modelled: 369 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: C: PDB Molecule:aminopeptidase p; PDBTitle: the structure of pseudomonas aeruginosa aminopeptidase pepp Phyre2 PDB 2zsg chain B Region: 20 - 372 Aligned: 350 Modelled: 353 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: B: PDB Molecule:aminopeptidase p, putative; PDBTitle: crystal structure of x-pro aminopeptidase from thermotoga maritima2 msb8 Phyre2 PDB 1w7v chain D Region: 5 - 369 Aligned: 363 Modelled: 365 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: D: PDB Molecule:xaa-pro aminopeptidase; PDBTitle: znmg substituted aminopeptidase p from e. coli Phyre2 PDB 5x49 chain A Region: 5 - 369 Aligned: 358 Modelled: 365 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:probable xaa-pro aminopeptidase 3; PDBTitle: crystal structure of human mitochondrial x-prolyl aminopeptidase2 (xpnpep3) Phyre2 PDB 2okn chain B Region: 3 - 369 Aligned: 363 Modelled: 367 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:xaa-pro dipeptidase; PDBTitle: crystal strcture of human prolidase Phyre2 PDB 4b28 chain A Region: 8 - 368 Aligned: 357 Modelled: 361 Confidence: 100.0% Identity: 22% PDB header:lyase Chain: A: PDB Molecule:metallopeptidase, family m24, putative; PDBTitle: crystal structure of dmsp lyase rddddp from roseobacter denitrificans Phyre2 PDB 4s2t chain P Region: 3 - 375 Aligned: 369 Modelled: 373 Confidence: 100.0% Identity: 20% PDB header:hydrolase/hydrolase inhibitor Chain: P: PDB Molecule:protein app-1; PDBTitle: crystal structure of x-prolyl aminopeptidase from caenorhabditis2 elegans: a cytosolic enzyme with a di-nuclear active site Phyre2 PDB 3ctz chain A Region: 3 - 375 Aligned: 367 Modelled: 373 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:xaa-pro aminopeptidase 1; PDBTitle: structure of human cytosolic x-prolyl aminopeptidase Phyre2 PDB 5xev chain A Region: 14 - 374 Aligned: 357 Modelled: 361 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:xaa-pro dipeptidase,peptidase-related protein; PDBTitle: crystal structure of a novel xaa-pro dipeptidase from deinococcus2 radiodurans Phyre2 PDB 3cb5 chain A Region: 2 - 369 Aligned: 361 Modelled: 368 Confidence: 100.0% Identity: 20% PDB header:transcription Chain: A: PDB Molecule:fact complex subunit spt16; PDBTitle: crystal structure of the s. pombe peptidase homology domain of fact2 complex subunit spt16 (form a) Phyre2 1 c4egeA_ 2 c4r60A_ 3 c1chmA_ 4 c4fkcA_ 5 c4zngA_ 6 c2howB_ 7 c1wy2B_ 8 c5cnxB_ 9 c3q6dA_ 10 c5cdlA_ 11 c5wzeC_ 12 c2zsgB_ 13 c1w7vD_ 14 c5x49A_ 15 c2oknB_ 16 c4b28A_ 17 c4s2tP_ 18 c3ctzA_ 19 c5xevA_ 20 c3cb5A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99