1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	A	A	G	L	L	K	R	L	N	P	R	N	R	R	S	R	V	N	P	D	A	T	M	S	L	V	D	H	L	T	E	L	R	T	R	L	L	I	S	L	A	A	I	L	V	T	T	I	F	G	F	V	W	Y	S	H	S	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	G	L	D	S	L	G	E	W	L	R	H	P	Y	C	A	L	P	Q	S	A	R	A	D	I	S	A	D	G	E	C	R	L	L	A	T	A	P	F	D	Q	F	M	L	R	L	K	V	G	M	A	A	G	I	V	L	A	C	P	V
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		W	F	Y	Q	L	W	A	F	I	T	P	G	L	Y	Q	R	E	R	R	F	A	V	A	F	V	I	P	A	A	V	L	F	V	A	G	A	V	L	A	Y	L	V	L	S	K	A	L	G	F	L	L	T	V	G	S	D	V	Q	V	T
Secondary structure
SS confidence
Disorder																																																										?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	L	S	G	D	R	Y	F	G	F	L	L	N	L	L	V	V	F	G	V	S	F	E	F	P	L	L	I	V	M	L	N	L	A	G	L	L	T	Y	E	R	L	K	S	W	R	R	G	L	I	F	A	M	F	V	F	A	A	I	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	P	G	S	D	P	F	S	M	T	A	L	G	A	A	L	T	V	L	L	E	L	A	I	Q	I	A	R	V	H	D	K	R	K	A	K	R	E	A	A	I	P	D	D	E	A	S	V	I	D	P	P	S	P	V	P	A	P	S	V
Secondary structure
SS confidence
Disorder			?																														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		I	G	S	H	D	D	V	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 71%) Beta strand ( 2%) TM helix ( 52%) (View membrane topology prediction)

Rank Aligned region

PDB 4b4a chain A Region: 29 - 268 Aligned: 221 Modelled: 223 Confidence: 100.0% Identity: 35% PDB header:transport protein Chain: A: PDB Molecule:sec-independent protein translocase protein tatc; PDBTitle: structure of the tatc core of the twin arginine protein2 translocation system Phyre2 PDB 1v54 chain L Region: 173 - 209 Aligned: 37 Modelled: 37 Confidence: 41.9% Identity: 22% Fold: Single transmembrane helix Superfamily: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) Family: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) Phyre2 PDB 6c08 chain C Region: 134 - 277 Aligned: 141 Modelled: 144 Confidence: 41.4% Identity: 11% PDB header:membrane protein Chain: C: PDB Molecule:sodium-coupled neutral amino acid transporter 9; PDBTitle: zebrafish slc38a9 with arginine bound in the cytosol open state Phyre2 PDB 2y69 chain Y Region: 173 - 209 Aligned: 37 Modelled: 37 Confidence: 39.2% Identity: 22% PDB header:electron transport Chain: Y: PDB Molecule:cytochrome c oxidase subunit 7c; PDBTitle: bovine heart cytochrome c oxidase re-refined with molecular oxygen Phyre2 PDB 2mdf chain A Region: 234 - 248 Aligned: 14 Modelled: 15 Confidence: 34.5% Identity: 29% PDB header:proton transport Chain: A: PDB Molecule:sodium/hydrogen exchanger 1; PDBTitle: nmr structure of a two-transmembrane segment tm vi-vii of nhe1 Phyre2 PDB 6ivu chain B Region: 211 - 237 Aligned: 27 Modelled: 27 Confidence: 33.8% Identity: 15% PDB header:transcription Chain: B: PDB Molecule:rna polymerase sigma factor sigi1; PDBTitle: solution structure of the sigma-anti-sigma factor complex rsgi1n-2 sigi1c from clostridium thermocellum Phyre2 PDB 2rdd chain B Region: 248 - 284 Aligned: 37 Modelled: 37 Confidence: 31.8% Identity: 16% PDB header:membrane protein/transport protein Chain: B: PDB Molecule:upf0092 membrane protein yajc; PDBTitle: x-ray crystal structure of acrb in complex with a novel2 transmembrane helix. Phyre2 PDB 3qod chain B Region: 12 - 41 Aligned: 30 Modelled: 30 Confidence: 30.7% Identity: 23% PDB header:dna binding protein Chain: B: PDB Molecule:heterocyst differentiation protein; PDBTitle: crystal structure of heterocyst differentiation protein, hetr from2 fischerella mv11 Phyre2 PDB 3rfu chain C Region: 31 - 174 Aligned: 102 Modelled: 105 Confidence: 30.6% Identity: 19% PDB header:hydrolase, membrane protein Chain: C: PDB Molecule:copper efflux atpase; PDBTitle: crystal structure of a copper-transporting pib-type atpase Phyre2 PDB 2knc chain A Region: 246 - 285 Aligned: 40 Modelled: 40 Confidence: 29.9% Identity: 18% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2oax chain C Region: 4 - 46 Aligned: 43 Modelled: 43 Confidence: 29.7% Identity: 16% PDB header:transcription Chain: C: PDB Molecule:mineralocorticoid receptor; PDBTitle: crystal structure of the s810l mutant mineralocorticoid2 receptor associated with sc9420 Phyre2 PDB 5cws chain F Region: 5 - 40 Aligned: 35 Modelled: 36 Confidence: 20.5% Identity: 29% PDB header:protein transport Chain: F: PDB Molecule:nucleoporin nic96; PDBTitle: crystal structure of the intact chaetomium thermophilum nsp1-nup49-2 nup57 channel nucleoporin heterotrimer bound to its nic96 nuclear3 pore complex attachment site Phyre2 PDB 5cws chain L Region: 5 - 40 Aligned: 35 Modelled: 36 Confidence: 17.6% Identity: 29% PDB header:protein transport Chain: L: PDB Molecule:nucleoporin nic96; PDBTitle: crystal structure of the intact chaetomium thermophilum nsp1-nup49-2 nup57 channel nucleoporin heterotrimer bound to its nic96 nuclear3 pore complex attachment site Phyre2 PDB 3lk2 chain B Region: 3 - 14 Aligned: 12 Modelled: 12 Confidence: 17.1% Identity: 42% PDB header:protein binding Chain: B: PDB Molecule:f-actin-capping protein subunit beta isoforms 1 and 2; PDBTitle: crystal structure of capz bound to the uncapping motif from carmil Phyre2 PDB 4akr chain B Region: 3 - 14 Aligned: 12 Modelled: 12 Confidence: 15.3% Identity: 33% PDB header:actin-binding protein Chain: B: PDB Molecule:f-actin-capping protein subunit beta; PDBTitle: crystal structure of the cytoplasmic actin capping protein2 cap32_34 from dictyostelium discoideum Phyre2 PDB 6roi chain A Region: 214 - 291 Aligned: 74 Modelled: 78 Confidence: 15.2% Identity: 15% PDB header:lipid transport Chain: A: PDB Molecule:probable phospholipid-transporting atpase drs2; PDBTitle: cryo-em structure of the partially activated drs2p-cdc50p Phyre2 PDB 4ojk chain D Region: 30 - 46 Aligned: 17 Modelled: 17 Confidence: 14.6% Identity: 47% PDB header:hydrolase/protein binding Chain: D: PDB Molecule:cgmp-dependent protein kinase 2; PDBTitle: structure of the cgmp dependent protein kinase ii and rab11b complex Phyre2 PDB 1izn chain B Region: 3 - 14 Aligned: 12 Modelled: 12 Confidence: 14.4% Identity: 42% Fold: Subunits of heterodimeric actin filament capping protein Capz Superfamily: Subunits of heterodimeric actin filament capping protein Capz Family: Capz beta-1 subunit Phyre2 PDB 3ukx chain C Region: 273 - 289 Aligned: 17 Modelled: 17 Confidence: 14.4% Identity: 29% PDB header:protein transport/inhibitor Chain: C: PDB Molecule:bimax2 peptide; PDBTitle: mouse importin alpha: bimax2 peptide complex Phyre2 PDB 3vw7 chain A Region: 11 - 56 Aligned: 46 Modelled: 46 Confidence: 13.3% Identity: 17% PDB header:signaling protein/antagonist Chain: A: PDB Molecule:proteinase-activated receptor 1, lysozyme; PDBTitle: crystal structure of human protease-activated receptor 1 (par1) bound2 with antagonist vorapaxar at 2.2 angstrom Phyre2 1 c4b4aA_ 2 d1v54l_ 3 c6c08C_ 4 c2y69Y_ 5 c2mdfA_ 6 c6ivuB_ 7 c2rddB_ 8 c3qodB_ 9 c3rfuC_ 10 c2kncA_ 11 c2oaxC_ 12 c5cwsF_ 13 c5cwsL_ 14 c3lk2B_ 15 c4akrB_ 16 c6roiA_ 17 c4ojkD_ 18 d1iznb_ 19 c3ukxC_ 20 c3vw7A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50