1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	Q	R	R	I	M	G	I	E	T	E	F	G	V	T	C	T	F	H	G	H	R	R	L	S	P	D	E	V	A	R	Y	L	F	R	R	V	V	S	W	G	R	S	S	N	V	F	L	R	N	G	A	R	L	Y	L	D	V	G	S
Secondary structure
SS confidence
Disorder		?	?	?	?															?	?	?	?	?	?	?														?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	P	E	Y	A	T	A	E	C	D	S	L	V	Q	L	V	T	H	D	R	A	G	E	W	V	L	E	D	L	L	V	D	A	E	Q	R	L	A	D	E	G	I	G	G	D	I	Y	L	F	K	N	N	T	D	S	A	G	N	S	Y
Secondary structure
SS confidence
Disorder																																								?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	C	H	E	N	Y	L	I	V	R	A	G	E	F	S	R	I	S	D	V	L	L	P	F	L	V	T	R	Q	L	I	C	G	A	G	K	V	L	Q	T	P	K	A	A	T	Y	C	L	S	Q	R	A	E	H	I	W	E	G	V	S
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	A	T	T	R	S	R	P	I	I	N	T	R	D	E	P	H	A	D	A	E	K	Y	R	R	L	H	V	I	V	G	D	S	N	M	S	E	T	T	T	M	L	K	V	G	T	A	A	L	V	L	E	M	I	E	S	G	V	A	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	D	F	S	L	D	N	P	I	R	A	I	R	E	V	S	H	D	V	T	G	R	R	P	V	R	L	A	G	G	R	Q	A	S	A	L	D	I	Q	R	E	Y	Y	T	R	A	V	E	H	L	Q	T	R	E	P	N	A	Q	I	E
Secondary structure
SS confidence
Disorder		?																																																			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	V	V	D	L	W	G	R	Q	L	D	A	V	E	S	Q	D	F	A	K	V	D	T	E	I	D	W	V	I	K	R	K	L	F	Q	R	Y	Q	D	R	Y	D	M	E	L	S	H	P	K	I	A	Q	L	D	L	A	Y	H	D	I
Secondary structure
SS confidence
Disorder																	?																							?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		K	R	G	R	G	I	F	D	L	L	Q	R	K	G	L	A	A	R	V	T	T	D	E	E	I	A	E	A	V	D	Q	P	P	Q	T	T	R	A	R	L	R	G	E	F	I	S	A	A	Q	E	A	G	R	D	F	T	V	D	W	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.
Sequence		H	L	K	L	N	D	Q	A	Q	R	T	V	L	C	K	D	P	F	R	A	V	D	E	R	V	K	R	L	I	A	S	M
Secondary structure
SS confidence
Disorder								?	?	?	?	?			?	?	?				?										?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 49%) Beta strand ( 13%)

Rank Aligned region

PDB 4b0t chain B Region: 1 - 452 Aligned: 447 Modelled: 452 Confidence: 100.0% Identity: 55% PDB header:ligase Chain: B: PDB Molecule:pup--protein ligase; PDBTitle: structure of the pup ligase pafa of the prokaryotic2 ubiquitin-like modification pathway in complex with adp Phyre2 PDB 4bjr chain A Region: 1 - 452 Aligned: 449 Modelled: 452 Confidence: 100.0% Identity: 54% PDB header:ligase Chain: A: PDB Molecule:pup--protein ligase, prokaryotic ubiquitin-like protein PDBTitle: crystal structure of the complex between prokaryotic2 ubiquitin-like protein pup and its ligase pafa Phyre2 PDB 4b0s chain A Region: 2 - 452 Aligned: 439 Modelled: 451 Confidence: 100.0% Identity: 41% PDB header:hydrolase Chain: A: PDB Molecule:deamidase-depupylase dop; PDBTitle: structure of the deamidase-depupylase dop of the prokaryotic2 ubiquitin-like modification pathway in complex with atp Phyre2 PDB 1r8g chain A Region: 6 - 308 Aligned: 291 Modelled: 302 Confidence: 96.8% Identity: 12% Fold: Glutamine synthetase/guanido kinase Superfamily: Glutamine synthetase/guanido kinase Family: Glutamate-cysteine ligase family 2 (GCS2) Phyre2 PDB 1tt4 chain A Region: 2 - 307 Aligned: 292 Modelled: 305 Confidence: 95.7% Identity: 11% Fold: Glutamine synthetase/guanido kinase Superfamily: Glutamine synthetase/guanido kinase Family: Glutamate-cysteine ligase family 2 (GCS2) Phyre2 PDB 1tt4 chain B Region: 2 - 307 Aligned: 292 Modelled: 305 Confidence: 95.7% Identity: 11% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative cytoplasmic protein; PDBTitle: structure of np459575, a predicted glutathione synthase from2 salmonella typhimurium Phyre2 PDB 2gwc chain E Region: 6 - 147 Aligned: 142 Modelled: 142 Confidence: 89.7% Identity: 13% PDB header:ligase Chain: E: PDB Molecule:glutamate cysteine ligase; PDBTitle: crystal structure of plant glutamate cysteine ligase in complex with a2 transition state analogue Phyre2 PDB 5cyw chain B Region: 109 - 122 Aligned: 14 Modelled: 14 Confidence: 50.9% Identity: 36% PDB header:viral protein Chain: B: PDB Molecule:interferon antagonist c7; PDBTitle: crystal structure of vaccinia virus c7 Phyre2 PDB 1ghh chain A Region: 391 - 452 Aligned: 58 Modelled: 62 Confidence: 49.2% Identity: 17% Fold: DNA damage-inducible protein DinI Superfamily: DNA damage-inducible protein DinI Family: DNA damage-inducible protein DinI Phyre2 PDB 5cz3 chain B Region: 109 - 122 Aligned: 14 Modelled: 14 Confidence: 49.2% Identity: 43% PDB header:viral protein Chain: B: PDB Molecule:m64r; PDBTitle: crystal structure of myxoma virus m64 Phyre2 PDB 2jg0 chain A domain 1 Region: 46 - 98 Aligned: 48 Modelled: 53 Confidence: 40.2% Identity: 19% Fold: alpha/alpha toroid Superfamily: Six-hairpin glycosidases Family: Trehalase-like Phyre2 PDB 2jg0 chain A Region: 46 - 98 Aligned: 48 Modelled: 53 Confidence: 40.2% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:periplasmic trehalase; PDBTitle: family 37 trehalase from escherichia coli in complex with 1-2 thiatrehazolin Phyre2 PDB 2kse chain A Region: 122 - 151 Aligned: 30 Modelled: 30 Confidence: 25.1% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:sensor protein qsec; PDBTitle: backbone structure of the membrane domain of e. coli histidine kinase2 receptor qsec, center for structures of membrane proteins (csmp)3 target 4311c Phyre2 PDB 3ff6 chain D Region: 329 - 408 Aligned: 58 Modelled: 80 Confidence: 21.1% Identity: 24% PDB header:ligase Chain: D: PDB Molecule:acetyl-coa carboxylase 2; PDBTitle: human acc2 ct domain with cp-640186 Phyre2 PDB 5m4a chain A Region: 46 - 98 Aligned: 48 Modelled: 53 Confidence: 20.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:neutral trehalase; PDBTitle: neutral trehalase nth1 from saccharomyces cerevisiae in complex with2 trehalose Phyre2 PDB 3cvj chain B Region: 42 - 115 Aligned: 72 Modelled: 74 Confidence: 17.3% Identity: 25% PDB header:isomerase Chain: B: PDB Molecule:putative phosphoheptose isomerase; PDBTitle: crystal structure of a putative phosphoheptose isomerase (bh3325) from2 bacillus halodurans c-125 at 2.00 a resolution Phyre2 PDB 2x24 chain B Region: 348 - 408 Aligned: 45 Modelled: 61 Confidence: 16.2% Identity: 27% PDB header:ligase Chain: B: PDB Molecule:acetyl-coa carboxylase; PDBTitle: bovine acc2 ct domain in complex with inhibitor Phyre2 PDB 3tad chain B Region: 349 - 399 Aligned: 48 Modelled: 51 Confidence: 15.5% Identity: 23% PDB header:protein binding Chain: B: PDB Molecule:liprin-alpha-2; PDBTitle: crystal structure of the liprin-alpha/liprin-beta complex Phyre2 PDB 4emt chain B Region: 46 - 67 Aligned: 19 Modelled: 22 Confidence: 14.5% Identity: 42% PDB header:membrane protein Chain: B: PDB Molecule:transmembrane protein 173; PDBTitle: crystal structure of human sting bound to c-di-gmp Phyre2 PDB 3o2i chain B Region: 255 - 312 Aligned: 54 Modelled: 58 Confidence: 14.3% Identity: 13% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of a functionally unknown protein from2 leptospirillum sp. group ii uba Phyre2 1 c4b0tB_ 2 c4bjrA_ 3 c4b0sA_ 4 d1r8ga_ 5 d1tt4a_ 6 c1tt4B_ 7 c2gwcE_ 8 c5cywB_ 9 d1ghha_ 10 c5cz3B_ 11 d2jg0a1 12 c2jg0A_ 13 c2kseA_ 14 c3ff6D_ 15 c5m4aA_ 16 c3cvjB_ 17 c2x24B_ 18 c3tadB_ 19 c4emtB_ 20 c3o2iB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99