1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	W	V	G	G	P	C	L	M	P	A	S	S	A	A	R	C	A	A	R	I	V	G	G	R	C	L	M	P	A	S	S	A	A	R	C	A	A	R	I	V	G	G	P	R	L	Y	G	M	Q	R	I	I	G	T	E	V	E	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?						?	?	?	?													?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	I	S	S	P	S	D	P	T	A	N	P	I	L	T	S	T	Q	A	V	L	A	Y	A	A	A	A	G	I	Q	R	A	K	R	T	R	W	D	Y	E	V	E	S	P	L	R	D	A	R	G	F	D	L	S	R	S	A	G	P	P
Secondary structure
SS confidence
Disorder										?	?					?								?	?	?	?	?	?	?	?	?	?	?		?	?		?		?			?		?							?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	V	V	D	A	D	E	V	G	A	A	N	M	I	L	T	N	G	A	R	L	Y	V	D	H	A	H	P	E	Y	S	A	P	E	C	T	D	P	L	D	A	V	I	W	D	K	A	G	E	R	V	M	E	A	A	A	R	H	V	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	V	P	G	A	A	K	L	Q	L	Y	K	N	N	V	D	G	K	G	A	S	Y	G	S	H	E	N	Y	L	M	S	R	Q	T	P	F	S	A	I	I	T	G	L	T	P	F	L	V	S	R	Q	V	V	T	G	S	G	R	V	G
Secondary structure
SS confidence
Disorder		?	?	?	?																																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	G	P	S	G	D	E	P	G	F	Q	L	S	Q	R	S	D	Y	I	E	V	E	V	G	L	E	T	T	L	K	R	G	I	I	N	T	R	D	E	P	H	A	D	A	D	R	Y	R	R	L	H	V	I	I	G	D	A	N	L	A
Secondary structure
SS confidence
Disorder			?	?	?	?	?		?	?	?															?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	T	S	T	Y	L	K	L	G	T	T	A	L	V	L	D	L	I	E	E	G	P	A	H	A	I	D	L	T	D	L	A	L	A	R	P	V	H	A	V	H	A	I	S	R	D	P	S	L	R	A	T	V	A	L	A	D	G	R	E
Secondary structure
SS confidence
Disorder																								?	?					?	?		?																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	T	G	L	A	L	Q	R	I	Y	L	D	R	V	A	K	L	V	D	S	R	D	P	D	P	R	A	A	D	I	V	E	T	W	A	H	V	L	D	Q	L	E	R	D	P	M	D	C	A	E	L	L	D	W	P	A	K	L	R	L
Secondary structure
SS confidence
Disorder																				?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	D	G	F	R	Q	R	E	N	L	S	W	S	A	P	R	L	H	L	V	D	L	Q	Y	S	D	V	R	L	D	K	G	L	Y	N	R	L	V	A	R	G	S	M	K	R	L	V	T	E	H	Q	V	L	S	A	V	E	N	P	P
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		T	D	T	R	A	Y	F	R	G	E	C	L	R	R	F	G	A	D	I	A	A	A	S	W	D	S	V	I	F	D	L	G	G	D	S	L	V	R	I	P	T	L	E	P	L	R	G	S	K	A	H	V	G	A	L	L	D	S	V	D
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.
Sequence		S	A	V	E	L	V	E	Q	L	T	A	E	P	R
Secondary structure
SS confidence
Disorder		?								?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 18%) Alpha helix ( 46%) Beta strand ( 13%)

Rank Aligned region

PDB 4b0s chain A Region: 50 - 550 Aligned: 452 Modelled: 456 Confidence: 100.0% Identity: 63% PDB header:hydrolase Chain: A: PDB Molecule:deamidase-depupylase dop; PDBTitle: structure of the deamidase-depupylase dop of the prokaryotic2 ubiquitin-like modification pathway in complex with atp Phyre2 PDB 4b0t chain B Region: 50 - 544 Aligned: 447 Modelled: 460 Confidence: 100.0% Identity: 38% PDB header:ligase Chain: B: PDB Molecule:pup--protein ligase; PDBTitle: structure of the pup ligase pafa of the prokaryotic2 ubiquitin-like modification pathway in complex with adp Phyre2 PDB 4bjr chain A Region: 50 - 551 Aligned: 452 Modelled: 461 Confidence: 100.0% Identity: 36% PDB header:ligase Chain: A: PDB Molecule:pup--protein ligase, prokaryotic ubiquitin-like protein PDBTitle: crystal structure of the complex between prokaryotic2 ubiquitin-like protein pup and its ligase pafa Phyre2 PDB 1r8g chain A Region: 54 - 396 Aligned: 285 Modelled: 294 Confidence: 95.1% Identity: 15% Fold: Glutamine synthetase/guanido kinase Superfamily: Glutamine synthetase/guanido kinase Family: Glutamate-cysteine ligase family 2 (GCS2) Phyre2 PDB 5cyw chain B Region: 191 - 204 Aligned: 14 Modelled: 14 Confidence: 48.4% Identity: 36% PDB header:viral protein Chain: B: PDB Molecule:interferon antagonist c7; PDBTitle: crystal structure of vaccinia virus c7 Phyre2 PDB 5cz3 chain B Region: 191 - 204 Aligned: 14 Modelled: 14 Confidence: 46.5% Identity: 36% PDB header:viral protein Chain: B: PDB Molecule:m64r; PDBTitle: crystal structure of myxoma virus m64 Phyre2 PDB 2jg0 chain A domain 1 Region: 133 - 181 Aligned: 45 Modelled: 49 Confidence: 37.7% Identity: 16% Fold: alpha/alpha toroid Superfamily: Six-hairpin glycosidases Family: Trehalase-like Phyre2 PDB 2jg0 chain A Region: 133 - 181 Aligned: 45 Modelled: 49 Confidence: 37.7% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:periplasmic trehalase; PDBTitle: family 37 trehalase from escherichia coli in complex with 1-2 thiatrehazolin Phyre2 PDB 1tt4 chain A Region: 54 - 395 Aligned: 277 Modelled: 289 Confidence: 30.2% Identity: 17% Fold: Glutamine synthetase/guanido kinase Superfamily: Glutamine synthetase/guanido kinase Family: Glutamate-cysteine ligase family 2 (GCS2) Phyre2 PDB 1tt4 chain B Region: 54 - 395 Aligned: 277 Modelled: 289 Confidence: 29.7% Identity: 17% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative cytoplasmic protein; PDBTitle: structure of np459575, a predicted glutathione synthase from2 salmonella typhimurium Phyre2 PDB 4i9g chain B Region: 292 - 395 Aligned: 104 Modelled: 104 Confidence: 29.2% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:glycerol 3-phosphate phosphatase; PDBTitle: crystal structure of glycerol phosphate phosphatase rv1692 from2 mycobacterium tuberculosis in complex with magnesium Phyre2 PDB 2kse chain A Region: 204 - 233 Aligned: 30 Modelled: 30 Confidence: 26.6% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:sensor protein qsec; PDBTitle: backbone structure of the membrane domain of e. coli histidine kinase2 receptor qsec, center for structures of membrane proteins (csmp)3 target 4311c Phyre2 PDB 5gmx chain A Region: 307 - 340 Aligned: 26 Modelled: 34 Confidence: 26.4% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:carboxylesterase; PDBTitle: crystal structure of a family viii carboxylesterase Phyre2 PDB 5e2h chain B Region: 307 - 337 Aligned: 23 Modelled: 31 Confidence: 23.7% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of d-alanine carboxypeptidase ampc from2 mycobacterium smegmatis Phyre2 PDB 2h2w chain A Region: 37 - 152 Aligned: 98 Modelled: 107 Confidence: 22.8% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:homoserine o-succinyltransferase; PDBTitle: crystal structure of homoserine o-succinyltransferase (ec 2.3.1.46)2 (homoserine o-transsuccinylase) (hts) (tm0881) from thermotoga3 maritima at 2.52 a resolution Phyre2 PDB 2gc6 chain A domain 1 Region: 134 - 147 Aligned: 14 Modelled: 14 Confidence: 20.1% Identity: 21% Fold: MurD-like peptide ligases, peptide-binding domain Superfamily: MurD-like peptide ligases, peptide-binding domain Family: Folylpolyglutamate synthetase, C-terminal domain Phyre2 PDB 2qz6 chain A Region: 307 - 338 Aligned: 24 Modelled: 24 Confidence: 20.1% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: first crystal structure of a psychrophile class c beta-2 lactamase Phyre2 PDB 5tgf chain B Region: 307 - 340 Aligned: 26 Modelled: 34 Confidence: 19.1% Identity: 27% PDB header:hydrolase Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of putative beta-lactamase from bacteroides dorei2 dsm 17855 Phyre2 PDB 1yqs chain A domain 1 Region: 307 - 340 Aligned: 26 Modelled: 34 Confidence: 17.8% Identity: 31% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 6njk chain A Region: 307 - 340 Aligned: 26 Modelled: 34 Confidence: 17.8% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of beta-lactamase from sulfitobacter sp. ee-36 Phyre2 1 c4b0sA_ 2 c4b0tB_ 3 c4bjrA_ 4 d1r8ga_ 5 c5cywB_ 6 c5cz3B_ 7 d2jg0a1 8 c2jg0A_ 9 d1tt4a_ 10 c1tt4B_ 11 c4i9gB_ 12 c2kseA_ 13 c5gmxA_ 14 c5e2hB_ 15 c2h2wA_ 16 d2gc6a1 17 c2qz6A_ 18 c5tgfB_ 19 d1yqsa1 20 c6njkA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99