1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	D	Q	P	D	P	P	T	P	R	P	A	L	S	P	S	R	A	T	D	F	K	Q	C	P	L	L	Y	R	F	R	A	I	D	R	L	P	E	A	T	S	A	A	Q	L	R	G	S	V	V	H	A	A	L	E	Q	L	Y	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?																																?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	P	A	G	L	R	S	P	D	T	A	R	S	L	V	Q	R	A	W	D	Q	M	V	A	A	E	P	E	L	A	G	E	L	D	P	G	Q	P	T	Q	L	L	E	D	A	R	A	L	V	S	G	Y	Y	R	L	E	D	P	T	R
Secondary structure
SS confidence
Disorder					?		?	?																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	D	P	Q	C	C	E	Q	R	V	E	V	E	L	A	D	G	T	L	L	R	G	Y	I	D	R	I	D	V	A	A	T	G	E	L	R	V	V	D	Y	K	T	G	K	A	P	P	A	A	R	A	L	A	E	F	K	A	M	F	Q
Secondary structure
SS confidence
Disorder																																														?	?	?	?	?	?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		M	K	F	Y	A	V	A	L	F	R	S	R	G	V	P	P	T	R	L	R	L	I	Y	L	A	D	G	Q	L	L	D	Y	S	P	D	R	D	E	L	L	R	F	E	K	T	L	M	A	I	W	R	A	I	Q	S	A	G	E	T	G
Secondary structure
SS confidence
Disorder																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.
Sequence		D	F	R	P	N	P	S	R	L	C	D	W	C	P	H	Q	Q	R	C	P	A	F	G	G	T	P	P	P	Y	P	G	W	P	T	E	P	A	A
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 45%) Beta strand ( 14%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 3u44 chain B Region: 10 - 267 Aligned: 257 Modelled: 258 Confidence: 100.0% Identity: 19% PDB header:hydrolase/dna Chain: B: PDB Molecule:atp-dependent helicase/deoxyribonuclease subunit b; PDBTitle: crystal structure of addab-dna complex Phyre2 PDB 4ic1 chain D Region: 19 - 261 Aligned: 171 Modelled: 188 Confidence: 99.8% Identity: 19% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of sso0001 Phyre2 PDB 5eax chain B Region: 10 - 271 Aligned: 252 Modelled: 262 Confidence: 99.8% Identity: 14% PDB header:hydrolase/dna Chain: B: PDB Molecule:dna replication atp-dependent helicase/nuclease dna2; PDBTitle: crystal structure of dna2 in complex with an ssdna Phyre2 PDB 4onb chain A Region: 7 - 259 Aligned: 161 Modelled: 182 Confidence: 99.8% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:crispr-associated exonuclease, cas4 family; PDBTitle: crystal structure of crispr-associated exonuclease (cas4 family) from2 pyrobaculum calidifontis jcm 11548 Phyre2 PDB 3l0a chain A Region: 14 - 253 Aligned: 212 Modelled: 215 Confidence: 99.7% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:putative exonuclease; PDBTitle: crystal structure of putative exonuclease (rer070207002219) from2 eubacterium rectale at 2.19 a resolution Phyre2 PDB 3h4r chain A Region: 12 - 243 Aligned: 199 Modelled: 207 Confidence: 99.6% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:exodeoxyribonuclease 8; PDBTitle: crystal structure of e. coli rece exonuclease Phyre2 PDB 3u4q chain A Region: 38 - 212 Aligned: 163 Modelled: 175 Confidence: 99.5% Identity: 15% PDB header:hydrolase/dna Chain: A: PDB Molecule:atp-dependent helicase/nuclease subunit a; PDBTitle: structure of addab-dna complex at 2.8 angstroms Phyre2 PDB 5zyu chain A Region: 13 - 241 Aligned: 184 Modelled: 197 Confidence: 99.2% Identity: 17% PDB header:dna binding protein/dna Chain: A: PDB Molecule:mitochondrial genome maintenance exonuclease 1; PDBTitle: the crytal struture of humanmgme1 with single strand dna2 Phyre2 PDB 1w36 chain F Region: 2 - 232 Aligned: 198 Modelled: 219 Confidence: 99.0% Identity: 16% PDB header:recombination Chain: F: PDB Molecule:exodeoxyribonuclease v gamma chain; PDBTitle: recbcd:dna complex Phyre2 PDB 1w36 chain E Region: 4 - 205 Aligned: 182 Modelled: 185 Confidence: 98.8% Identity: 16% PDB header:recombination Chain: E: PDB Molecule:exodeoxyribonuclease v beta chain; PDBTitle: recbcd:dna complex Phyre2 PDB 1w36 chain B domain 3 Region: 45 - 190 Aligned: 131 Modelled: 133 Confidence: 98.4% Identity: 18% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Exodeoxyribonuclease V beta chain (RecB), C-terminal domain Phyre2 PDB 5gke chain B Region: 103 - 202 Aligned: 82 Modelled: 100 Confidence: 89.8% Identity: 22% PDB header:hydrolase/dna Chain: B: PDB Molecule:endonuclease endoms; PDBTitle: structure of endoms-dsdna1 complex Phyre2 PDB 2vld chain A Region: 103 - 202 Aligned: 82 Modelled: 100 Confidence: 84.8% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease nucs; PDBTitle: crystal structure of a repair endonuclease from pyrococcus abyssi Phyre2 PDB 1rrq chain A domain 1 Region: 242 - 271 Aligned: 30 Modelled: 30 Confidence: 80.0% Identity: 30% Fold: DNA-glycosylase Superfamily: DNA-glycosylase Family: Mismatch glycosylase Phyre2 PDB 1w36 chain C domain 3 Region: 4 - 232 Aligned: 200 Modelled: 222 Confidence: 72.4% Identity: 15% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Exodeoxyribonuclease V beta chain (RecC), C-terminal domain Phyre2 PDB 1kg2 chain A Region: 242 - 271 Aligned: 30 Modelled: 30 Confidence: 71.5% Identity: 30% Fold: DNA-glycosylase Superfamily: DNA-glycosylase Family: Mismatch glycosylase Phyre2 PDB 4unf chain A Region: 242 - 271 Aligned: 30 Modelled: 30 Confidence: 64.1% Identity: 20% PDB header:lyase Chain: A: PDB Molecule:endonuclease iii-1; PDBTitle: crystal structure of deinococcus radiodurans endonuclease iii-1 Phyre2 PDB 1rrq chain A Region: 242 - 270 Aligned: 29 Modelled: 29 Confidence: 55.1% Identity: 31% PDB header:hydrolase/dna Chain: A: PDB Molecule:muty; PDBTitle: muty adenine glycosylase in complex with dna containing an2 a:oxog pair Phyre2 PDB 2abk chain A Region: 242 - 266 Aligned: 25 Modelled: 25 Confidence: 54.6% Identity: 12% Fold: DNA-glycosylase Superfamily: DNA-glycosylase Family: Endonuclease III Phyre2 PDB 1orn chain A Region: 242 - 263 Aligned: 22 Modelled: 22 Confidence: 49.6% Identity: 23% Fold: DNA-glycosylase Superfamily: DNA-glycosylase Family: Endonuclease III Phyre2 1 c3u44B_ 2 c4ic1D_ 3 c5eaxB_ 4 c4onbA_ 5 c3l0aA_ 6 c3h4rA_ 7 c3u4qA_ 8 c5zyuA_ 9 c1w36F_ 10 c1w36E_ 11 d1w36b3 12 c5gkeB_ 13 c2vldA_ 14 d1rrqa1 15 d1w36c3 16 d1kg2a_ 17 c4unfA_ 18 c1rrqA_ 19 d2abka_ 20 d1orna_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99