1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	D	E	T	G	A	S	S	D	H	S	D	D	V	A	Q	V	V	S	R	L	I	R	F	D	T	T	N	S	G	E	P	G	T	T	K	G	E	A	E	C	A	R	W	V	A	E	Q	L	A	E	V	G	Y	Q	P	E	Y	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																								?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	S	G	A	P	G	R	G	N	V	F	A	R	L	A	G	A	D	S	S	R	G	A	L	L	I	H	G	H	L	D	V	V	P	A	E	P	A	E	W	S	V	H	P	F	S	G	A	I	E	D	G	Y	V	W	G	R	G	A	V
Secondary structure
SS confidence
Disorder																																							?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	M	K	D	M	V	G	M	M	I	V	V	A	R	H	L	R	Q	A	A	I	V	P	P	R	D	L	V	F	A	F	V	A	D	E	E	H	G	G	K	Y	G	S	H	W	L	V	D	N	R	P	D	L	F	D	G	I	T	E	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	G	E	V	G	G	F	S	L	T	V	P	R	H	D	G	G	E	R	R	L	Y	L	I	E	T	A	E	K	G	I	Q	W	M	R	L	T	A	R	G	R	A	G	H	G	S	M	V	H	D	Q	N	A	V	T	A	V	C	E	A
Secondary structure
SS confidence
Disorder													?	?	?	?	?		?		?																								?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	A	R	L	G	R	H	Q	F	P	L	V	C	T	D	T	V	A	Q	F	L	A	V	V	G	E	E	T	G	L	A	F	D	L	D	S	P	D	L	A	G	T	I	D	K	L	G	P	M	A	R	M	L	K	A	V	L	H	D	T
Secondary structure
SS confidence
Disorder																													?	?								?	?							?	?			?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	N	P	T	M	L	K	A	G	Y	K	A	N	V	V	P	A	T	A	E	A	V	V	D	C	R	V	L	P	G	R	R	A	A	F	E	A	E	V	D	A	L	I	G	P	D	V	T	R	E	W	V	S	D	L	P	S	Y	E	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		T	F	D	G	D	L	V	A	A	M	N	A	A	V	L	A	V	D	P	D	G	R	T	V	P	Y	M	L	S	G	G	T	D	A	K	A	F	A	R	L	G	I	R	C	F	G	F	S	P	L	R	L	P	P	D	L	D	F	T	S
Secondary structure
SS confidence
Disorder																																																							?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.
Sequence		L	F	H	G	V	D	E	R	V	P	I	D	G	L	R	F	G	T	E	V	L	T	H	L	L	T	H	C
Secondary structure
SS confidence
Disorder																												?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 34%) Beta strand ( 23%)

Rank Aligned region

PDB 2pok chain B Region: 10 - 447 Aligned: 416 Modelled: 438 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m20/m25/m40 family; PDBTitle: crystal structure of a m20 family metallo peptidase from streptococcus2 pneumoniae Phyre2 PDB 2zog chain A Region: 10 - 447 Aligned: 421 Modelled: 432 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:cytosolic non-specific dipeptidase; PDBTitle: crystal structure of mouse carnosinase cn2 complexed with zn and2 bestatin Phyre2 PDB 4g1p chain A Region: 10 - 447 Aligned: 422 Modelled: 429 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:cys-gly metallodipeptidase dug1; PDBTitle: structural and mechanistic basis of substrate recognition by novel di-2 peptidase dug1p from saccharomyces cerevisiae Phyre2 PDB 3dlj chain B Region: 10 - 447 Aligned: 419 Modelled: 427 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:beta-ala-his dipeptidase; PDBTitle: crystal structure of human carnosine dipeptidase 1 Phyre2 PDB 3pfe chain A Region: 12 - 447 Aligned: 417 Modelled: 426 Confidence: 100.0% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:succinyl-diaminopimelate desuccinylase; PDBTitle: crystal structure of a m20a metallo peptidase (dape, lpg0809) from2 legionella pneumophila subsp. pneumophila str. philadelphia 1 at 1.503 a resolution Phyre2 PDB 3pfo chain B Region: 10 - 445 Aligned: 369 Modelled: 386 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:putative acetylornithine deacetylase; PDBTitle: crystal structure of a putative acetylornithine deacetylase (rpa2325)2 from rhodopseudomonas palustris cga009 at 1.90 a resolution Phyre2 PDB 5k8n chain E Region: 10 - 446 Aligned: 381 Modelled: 404 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: E: PDB Molecule:5-nitroanthranilic acid aminohydrolase; PDBTitle: 5naa-bound 5-nitroanthranilate aminohydrolase Phyre2 PDB 1vgy chain B Region: 13 - 447 Aligned: 364 Modelled: 394 Confidence: 100.0% Identity: 21% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:succinyl-diaminopimelate desuccinylase; PDBTitle: crystal structure of succinyl diaminopimelate desuccinylase Phyre2 PDB 1lfw chain A Region: 10 - 445 Aligned: 396 Modelled: 407 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:pepv; PDBTitle: crystal structure of pepv Phyre2 PDB 3mru chain B Region: 13 - 447 Aligned: 407 Modelled: 428 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:aminoacyl-histidine dipeptidase; PDBTitle: crystal structure of aminoacylhistidine dipeptidase from vibrio2 alginolyticus Phyre2 PDB 2rb7 chain A Region: 9 - 447 Aligned: 350 Modelled: 374 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:peptidase, m20/m25/m40 family; PDBTitle: crystal structure of co-catalytic metallopeptidase (yp_387682.1) from2 desulfovibrio desulfuricans g20 at 1.60 a resolution Phyre2 PDB 1cg2 chain D Region: 10 - 447 Aligned: 361 Modelled: 379 Confidence: 100.0% Identity: 22% PDB header:metallocarboxypeptidase Chain: D: PDB Molecule:carboxypeptidase g2; PDBTitle: carboxypeptidase g2 Phyre2 PDB 2f7v chain A Region: 9 - 446 Aligned: 352 Modelled: 379 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:aectylcitrulline deacetylase; PDBTitle: structure of acetylcitrulline deacetylase complexed with2 one co Phyre2 PDB 3khz chain A Region: 10 - 445 Aligned: 357 Modelled: 366 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:putative dipeptidase sacol1801; PDBTitle: crystal structure of r350a mutant of staphylococcus aureus2 metallopeptidase (sapep/dape) in the apo-form Phyre2 PDB 4ewt chain C Region: 10 - 445 Aligned: 366 Modelled: 385 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: C: PDB Molecule:peptidase, m20/m25/m40 family; PDBTitle: the crystal structure of a putative aminohydrolase from methicillin2 resistant staphylococcus aureus Phyre2 PDB 3ic1 chain A Region: 12 - 447 Aligned: 361 Modelled: 384 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:succinyl-diaminopimelate desuccinylase; PDBTitle: crystal structure of zinc-bound succinyl-diaminopimelate desuccinylase2 from haemophilus influenzae Phyre2 PDB 3ct9 chain B Region: 9 - 447 Aligned: 341 Modelled: 358 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:acetylornithine deacetylase; PDBTitle: crystal structure of a putative zinc peptidase (np_812461.1) from2 bacteroides thetaiotaomicron vpi-5482 at 2.31 a resolution Phyre2 PDB 3gb0 chain A Region: 9 - 446 Aligned: 351 Modelled: 364 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:peptidase t; PDBTitle: crystal structure of aminopeptidase pept (np_980509.1) from bacillus2 cereus atcc 10987 at 2.04 a resolution Phyre2 PDB 2qyv chain B Region: 13 - 447 Aligned: 406 Modelled: 417 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:xaa-his dipeptidase; PDBTitle: crystal structure of putative xaa-his dipeptidase (yp_718209.1) from2 haemophilus somnus 129pt at 2.11 a resolution Phyre2 PDB 3rza chain A Region: 9 - 446 Aligned: 351 Modelled: 368 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:tripeptidase; PDBTitle: crystal structure of a tripeptidase (sav1512) from staphylococcus2 aureus subsp. aureus mu50 at 2.10 a resolution Phyre2 1 c2pokB_ 2 c2zogA_ 3 c4g1pA_ 4 c3dljB_ 5 c3pfeA_ 6 c3pfoB_ 7 c5k8nE_ 8 c1vgyB_ 9 c1lfwA_ 10 c3mruB_ 11 c2rb7A_ 12 c1cg2D_ 13 c2f7vA_ 14 c3khzA_ 15 c4ewtC_ 16 c3ic1A_ 17 c3ct9B_ 18 c3gb0A_ 19 c2qyvB_ 20 c3rzaA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137