1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	Q	I	L	I	A	V	A	V	A	V	T	V	S	I	L	L	T	P	V	L	I	R	L	F	T	K	Q	G	F	G	H	Q	I	R	E	D	G	P	P	S	H	H	T	K	R	G	T	P	S	M	G	G	V	A	I	L	A	G
Secondary structure
SS confidence
Disorder		?																															?	?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	W	A	G	Y	L	G	A	H	L	A	G	L	A	F	D	G	E	G	I	G	A	S	G	L	L	V	L	G	L	A	T	A	L	G	G	V	G	F	I	D	D	L	I	K	I	R	R	S	R	N	L	G	L	N	K	T	A	K	T
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?	?	?																										?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	G	Q	I	T	S	A	V	L	F	G	V	L	V	L	Q	F	R	N	A	A	G	L	T	P	G	S	A	D	L	S	Y	V	R	E	I	A	T	V	T	L	A	P	V	L	F	V	L	F	C	V	V	I	V	S	A	W	S	N	A
Secondary structure
SS confidence
Disorder																						?	?	?	?				?	?	?	?					?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	N	F	T	D	G	L	D	G	L	A	A	G	T	M	A	M	V	T	A	A	Y	V	L	I	T	F	W	Q	Y	R	N	A	C	V	T	A	P	G	L	G	C	Y	N	V	R	D	P	L	D	L	A	L	I	A	A	A	T	A	G
Secondary structure
SS confidence
Disorder																																	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	C	I	G	F	L	W	W	N	A	A	P	A	K	I	F	M	G	D	T	G	S	L	A	L	G	G	V	I	A	G	L	S	V	T	S	R	T	E	I	L	A	V	V	L	G	A	L	F	V	A	E	I	T	S	V	V	L	Q	I
Secondary structure
SS confidence
Disorder																																					?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.
Sequence		L	T	F	R	T	T	G	R	R	M	F	R	M	A	P	F	H	H	H	F	E	L	V	G	W	A	E	T	T	V	I	I	R	F	W	L	L	T	A	I	T	C	G	L	G	V	A	L	F	Y	G	E	W	L	A	A	V	G	A
Secondary structure
SS confidence
Disorder										?	?																																															?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 72%) Beta strand ( 0%) TM helix ( 62%) (View membrane topology prediction)

Rank Aligned region

PDB 4j72 chain A Region: 9 - 348 Aligned: 316 Modelled: 340 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:phospho-n-acetylmuramoyl-pentapeptide-transferase; PDBTitle: crystal structure of polyprenyl-phosphate n-acetyl hexosamine 1-2 phosphate transferase Phyre2 PDB 5jnq chain A Region: 1 - 347 Aligned: 295 Modelled: 313 Confidence: 100.0% Identity: 35% PDB header:transferase/antibiotic Chain: A: PDB Molecule:phospho-n-acetylmuramoyl-pentapeptide-transferase; PDBTitle: mray tunicamycin complex Phyre2 PDB 4j72 chain B Region: 5 - 347 Aligned: 281 Modelled: 303 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: B: PDB Molecule:phospho-n-acetylmuramoyl-pentapeptide-transferase; PDBTitle: crystal structure of polyprenyl-phosphate n-acetyl hexosamine 1-2 phosphate transferase Phyre2 PDB 5lev chain A Region: 1 - 350 Aligned: 312 Modelled: 343 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:udp-n-acetylglucosamine--dolichyl-phosphate n- PDBTitle: crystal structure of human udp-n-acetylglucosamine-dolichyl-phosphate2 n-acetylglucosaminephosphotransferase (dpagt1) (v264g mutant) Phyre2 PDB 6m97 chain A Region: 190 - 253 Aligned: 43 Modelled: 43 Confidence: 57.5% Identity: 23% PDB header:transport protein Chain: A: PDB Molecule:chimera protein of high affinity copper uptake protein 1 PDBTitle: crystal structure of the high-affinity copper transporter ctr1 Phyre2 PDB 2k74 chain A Region: 279 - 319 Aligned: 38 Modelled: 41 Confidence: 55.0% Identity: 24% PDB header:membrane protein, oxidoreductase Chain: A: PDB Molecule:disulfide bond formation protein b; PDBTitle: solution nmr structure of dsbb-ubiquinone complex Phyre2 PDB 1o5h chain A Region: 30 - 76 Aligned: 47 Modelled: 47 Confidence: 25.6% Identity: 17% Fold: Methenyltetrahydrofolate cyclohydrolase-like Superfamily: Methenyltetrahydrofolate cyclohydrolase-like Family: Methenyltetrahydrofolate cyclohydrolase-like Phyre2 PDB 5gas chain N Region: 5 - 194 Aligned: 148 Modelled: 172 Confidence: 23.7% Identity: 21% PDB header:hydrolase Chain: N: PDB Molecule:archaeal/vacuolar-type h+-atpase subunit i; PDBTitle: thermus thermophilus v/a-atpase, conformation 2 Phyre2 PDB 4ntf chain A Region: 2 - 54 Aligned: 40 Modelled: 40 Confidence: 23.0% Identity: 10% PDB header:lyase Chain: A: PDB Molecule:leukotriene c4 synthase; PDBTitle: mus musculus ltc4 synthase in s-hexyl-gsh complex form Phyre2 PDB 2uui chain A Region: 2 - 54 Aligned: 40 Modelled: 40 Confidence: 21.0% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 3b29 chain A Region: 2 - 54 Aligned: 40 Modelled: 40 Confidence: 18.6% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:leukotriene c4 synthase; PDBTitle: human leukotriene c4 synthase in complex with dodecyl-beta-d-2 selenomaltoside Phyre2 PDB 6btm chain D Region: 183 - 252 Aligned: 69 Modelled: 70 Confidence: 16.8% Identity: 14% PDB header:membrane protein Chain: D: PDB Molecule:alternative complex iii subunit d; PDBTitle: structure of alternative complex iii from flavobacterium johnsoniae2 (wild type) Phyre2 PDB 2pno chain H Region: 2 - 54 Aligned: 40 Modelled: 40 Confidence: 16.7% Identity: 13% PDB header:lyase Chain: H: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2pno chain C Region: 2 - 54 Aligned: 40 Modelled: 53 Confidence: 16.7% Identity: 13% PDB header:lyase Chain: C: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2pno chain K Region: 2 - 54 Aligned: 40 Modelled: 40 Confidence: 16.7% Identity: 13% PDB header:lyase Chain: K: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2pno chain B Region: 2 - 54 Aligned: 40 Modelled: 53 Confidence: 16.7% Identity: 13% PDB header:lyase Chain: B: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2pno chain L Region: 2 - 54 Aligned: 40 Modelled: 53 Confidence: 16.7% Identity: 13% PDB header:lyase Chain: L: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2pno chain E Region: 2 - 54 Aligned: 40 Modelled: 53 Confidence: 16.7% Identity: 13% PDB header:lyase Chain: E: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2pno chain F Region: 2 - 54 Aligned: 40 Modelled: 53 Confidence: 16.7% Identity: 13% PDB header:lyase Chain: F: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2pno chain D Region: 2 - 54 Aligned: 40 Modelled: 53 Confidence: 16.7% Identity: 13% PDB header:lyase Chain: D: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 1 c4j72A_ 2 c5jnqA_ 3 c4j72B_ 4 c5levA_ 5 c6m97A_ 6 c2k74A_ 7 d1o5ha_ 8 c5gasN_ 9 c4ntfA_ 10 c2uuiA_ 11 c3b29A_ 12 c6btmD_ 13 c2pnoH_ 14 c2pnoC_ 15 c2pnoK_ 16 c2pnoB_ 17 c2pnoL_ 18 c2pnoE_ 19 c2pnoF_ 20 c2pnoD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46