1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	F	V	N	H	I	E	P	V	A	P	R	R	A	G	G	A	V	A	E	V	Y	A	E	A	R	R	E	F	G	R	L	P	E	P	L	A	M	L	S	P	D	E	G	L	L	T	A	G	W	A	T	L	R	E	T	L	L	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?				?	?	?																																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	Q	V	P	R	G	R	K	E	A	V	A	A	A	V	A	A	S	L	R	C	P	W	C	V	D	A	H	T	T	M	L	Y	A	A	G	Q	T	D	T	A	A	A	I	L	A	G	T	A	P	A	A	G	D	P	N	A	P	Y	V
Secondary structure
SS confidence
Disorder		?	?	?																																?	?	?	?							?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	W	A	A	G	T	G	T	P	A	G	P	P	A	P	F	G	P	D	V	A	A	E	Y	L	G	T	A	V	Q	F	H	F	I	A	R	L	V	L	V	L	L	D	E	T	F	L	P	G	G	P	R	A	Q	Q	L	M	R	R	A
Secondary structure
SS confidence
Disorder							?		?	?	?	?	?	?	?	?																													?	?	?	?	?	?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	G	L	V	F	A	R	K	V	R	A	E	H	R	P	G	R	S	T	R	R	L	E	P	R	T	L	P	D	D	L	A	W	A	T	P	S	E	P	I	A	T	A	F	A	A	L	S	H	H	L	D	T	A	P	H	L	P	P	P
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																						?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	R	Q	V	V	R	R	V	V	G	S	W	H	G	E	P	M	P	M	S	S	R	W	T	N	E	H	T	A	E	L	P	A	D	L	H	A	P	T	R	L	A	L	L	T	G	L	A	P	H	Q	V	T	D	D	D	V	A	A	A
Secondary structure
SS confidence
Disorder												?		?	?	?	?	?		?	?													?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.
Sequence		R	S	L	L	D	T	D	A	A	L	V	G	A	L	A	W	A	A	F	T	A	A	R	R	I	G	T	W	I	G	A	A	A	E	G	Q	V	S	R	Q	N	P	T	G
Secondary structure
SS confidence
Disorder																													?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 30%) Alpha helix ( 64%) Beta strand ( 0%) TM helix ( 5%) (View membrane topology prediction)

Rank Aligned region

PDB 2prr chain A domain 1 Region: 4 - 165 Aligned: 162 Modelled: 159 Confidence: 100.0% Identity: 16% Fold: AhpD-like Superfamily: AhpD-like Family: Atu0492-like Phyre2 PDB 2oyo chain A domain 1 Region: 4 - 164 Aligned: 161 Modelled: 161 Confidence: 100.0% Identity: 18% Fold: AhpD-like Superfamily: AhpD-like Family: Atu0492-like Phyre2 PDB 2pfx chain A domain 1 Region: 2 - 164 Aligned: 163 Modelled: 161 Confidence: 100.0% Identity: 14% Fold: AhpD-like Superfamily: AhpD-like Family: Atu0492-like Phyre2 PDB 3c1l chain B Region: 9 - 164 Aligned: 156 Modelled: 156 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: B: PDB Molecule:putative antioxidant defense protein mlr4105; PDBTitle: crystal structure of an antioxidant defense protein (mlr4105) from2 mesorhizobium loti maff303099 at 2.00 a resolution Phyre2 PDB 6ohi chain A Region: 4 - 164 Aligned: 161 Modelled: 161 Confidence: 100.0% Identity: 14% PDB header:biosynthetic protein Chain: A: PDB Molecule:debrominase bmp8; PDBTitle: crystal structure of the debrominase bmp8 (apo) Phyre2 PDB 3lvy chain B Region: 6 - 164 Aligned: 158 Modelled: 159 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: B: PDB Molecule:carboxymuconolactone decarboxylase family; PDBTitle: crystal structure of carboxymuconolactone decarboxylase2 family protein smu.961 from streptococcus mutans Phyre2 PDB 2ouw chain A domain 1 Region: 6 - 164 Aligned: 120 Modelled: 120 Confidence: 99.9% Identity: 20% Fold: AhpD-like Superfamily: AhpD-like Family: TTHA0727-like Phyre2 PDB 2gmy chain A domain 1 Region: 37 - 167 Aligned: 130 Modelled: 131 Confidence: 99.9% Identity: 10% Fold: AhpD-like Superfamily: AhpD-like Family: Atu0492-like Phyre2 PDB 2o4d chain A domain 1 Region: 37 - 165 Aligned: 128 Modelled: 126 Confidence: 99.9% Identity: 17% Fold: AhpD-like Superfamily: AhpD-like Family: Atu0492-like Phyre2 PDB 2qeu chain A Region: 13 - 126 Aligned: 114 Modelled: 114 Confidence: 99.6% Identity: 20% PDB header:lyase Chain: A: PDB Molecule:putative carboxymuconolactone decarboxylase; PDBTitle: crystal structure of putative carboxymuconolactone decarboxylase2 (yp_555818.1) from burkholderia xenovorans lb400 at 1.65 a resolution Phyre2 PDB 5dj4 chain D Region: 30 - 167 Aligned: 133 Modelled: 133 Confidence: 99.6% Identity: 14% PDB header:signaling protein Chain: D: PDB Molecule:sestrin-2; PDBTitle: leucine-bound sestrin2 from homo sapiens Phyre2 PDB 2cwq chain A domain 1 Region: 20 - 103 Aligned: 84 Modelled: 84 Confidence: 99.4% Identity: 18% Fold: AhpD-like Superfamily: AhpD-like Family: TTHA0727-like Phyre2 PDB 5dip chain B Region: 24 - 161 Aligned: 99 Modelled: 99 Confidence: 99.4% Identity: 23% PDB header:oxidoreductase Chain: B: PDB Molecule:alkyl hydroperoxide reductase ahpd; PDBTitle: crystal structure of lpg0406 in reduced form from legionella2 pneumophila Phyre2 PDB 1p8c chain D Region: 18 - 103 Aligned: 80 Modelled: 86 Confidence: 99.3% Identity: 18% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:conserved hypothetical protein; PDBTitle: crystal structure of tm1620 (apc4843) from thermotoga2 maritima Phyre2 PDB 1vke chain A Region: 23 - 102 Aligned: 74 Modelled: 80 Confidence: 99.3% Identity: 22% Fold: AhpD-like Superfamily: AhpD-like Family: CMD-like Phyre2 PDB 5gzx chain D Region: 7 - 105 Aligned: 99 Modelled: 99 Confidence: 99.2% Identity: 20% PDB header:hydrolase Chain: D: PDB Molecule:(r)-2-haloacid dehalogenase; PDBTitle: the complex structure of d-2-haloacid dehalogenase mutant with d-2-cpa Phyre2 PDB 3bey chain C Region: 38 - 103 Aligned: 66 Modelled: 66 Confidence: 99.2% Identity: 18% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:conserved protein o27018; PDBTitle: crystal structure of the protein o27018 from methanobacterium2 thermoautotrophicum. northeast structural genomics consortium target3 tt217 Phyre2 PDB 2q0t chain A domain 1 Region: 10 - 275 Aligned: 212 Modelled: 211 Confidence: 99.1% Identity: 14% Fold: AhpD-like Superfamily: AhpD-like Family: AhpD Phyre2 PDB 3d7i chain B Region: 35 - 161 Aligned: 88 Modelled: 85 Confidence: 99.1% Identity: 9% PDB header:lyase Chain: B: PDB Molecule:carboxymuconolactone decarboxylase family protein; PDBTitle: crystal structure of carboxymuconolactone decarboxylase family protein2 possibly involved in oxygen detoxification (1591455) from3 methanococcus jannaschii at 1.75 a resolution Phyre2 PDB 1vke chain B Region: 48 - 103 Aligned: 56 Modelled: 56 Confidence: 98.9% Identity: 18% Fold: AhpD-like Superfamily: AhpD-like Family: CMD-like Phyre2 1 d2prra1 2 d2oyoa1 3 d2pfxa1 4 c3c1lB_ 5 c6ohiA_ 6 c3lvyB_ 7 d2ouwa1 8 d2gmya1 9 d2o4da1 10 c2qeuA_ 11 c5dj4D_ 12 d2cwqa1 13 c5dipB_ 14 c1p8cD_ 15 d1vkea_ 16 c5gzxD_ 17 c3beyC_ 18 d2q0ta1 19 c3d7iB_ 20 d1vkeb_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99