1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	L	N	T	I	A	L	E	L	V	P	P	N	L	E	G	G	K	E	R	A	I	E	D	A	R	K	V	V	Q	Y	S	A	A	S	G	L	D	G	R	I	R	H	V	M	M	P	G	M	I	A	E	D	D	D	R	P	I	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?							?	?	?	?		?	?	?																													?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	Q	P	K	L	D	V	L	D	F	W	S	I	I	K	P	E	L	A	G	V	H	G	L	C	T	Q	V	T	A	F	M	D	E	P	S	L	H	R	R	L	V	D	L	S	D	A	G	M	E	G	I	V	F	V	G	V	P	R	T
Secondary structure
SS confidence
Disorder				?														?		?		?																																						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	Q	D	G	E	G	S	G	V	A	P	T	D	A	L	S	L	Y	R	Q	L	V	A	N	R	G	V	I	V	I	P	T	R	D	G	E	Q	G	R	L	N	F	K	C	S	R	G	A	T	Y	G	M	T	Q	L	L	Y	S	D	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?								?		?			?									?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	V	G	F	L	R	E	F	A	R	T	T	E	H	R	P	E	I	L	L	S	F	G	F	V	P	K	V	E	T	R	I	G	L	I	N	W	L	I	Q	D	P	G	N	A	A	V	A	D	E	Q	A	F	V	Q	K	L	A	G	S
Secondary structure
SS confidence
Disorder																												?			?													?	?	?		?	?	?										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	P	A	R	R	R	R	L	M	V	D	L	Y	K	R	V	L	D	G	V	A	D	L	G	F	P	L	S	I	H	L	E	A	T	Y	G	V	S	A	A	A	F	E	T	F	A	E	M	L	A	Y	W	S	P	A	E	P	G	K	P
Secondary structure
SS confidence
Disorder		?	?	?																																																				?	?	?	?	?	?
Disorder confidence
		.
Sequence		D
Secondary structure
SS confidence
Disorder		?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 45%) Beta strand ( 19%)

Rank Aligned region

PDB 3ijd chain B Region: 4 - 273 Aligned: 239 Modelled: 256 Confidence: 100.0% Identity: 18% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: uncharacterized protein cthe_2304 from clostridium thermocellum binds2 two copies of 5-methyl-5,6,7,8-tetrahydrofolic acid Phyre2 PDB 6fnu chain A Region: 5 - 283 Aligned: 258 Modelled: 267 Confidence: 99.9% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:methylenetetrahydrofolate reductase 1; PDBTitle: structure of s. cerevisiae methylenetetrahydrofolate reductase 1,2 catalytic domain Phyre2 PDB 1v93 chain A Region: 5 - 295 Aligned: 262 Modelled: 291 Confidence: 99.8% Identity: 19% Fold: TIM beta/alpha-barrel Superfamily: FAD-linked oxidoreductase Family: Methylenetetrahydrofolate reductase Phyre2 PDB 1b5t chain A Region: 5 - 271 Aligned: 241 Modelled: 255 Confidence: 99.7% Identity: 14% Fold: TIM beta/alpha-barrel Superfamily: FAD-linked oxidoreductase Family: Methylenetetrahydrofolate reductase Phyre2 PDB 2fmo chain A Region: 5 - 271 Aligned: 229 Modelled: 250 Confidence: 99.6% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:5,10-methylenetetrahydrofolate reductase; PDBTitle: ala177val mutant of e. coli methylenetetrahydrofolate2 reductase Phyre2 PDB 6fcx chain A Region: 4 - 271 Aligned: 240 Modelled: 268 Confidence: 99.5% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:methylenetetrahydrofolate reductase; PDBTitle: structure of human 5,10-methylenetetrahydrofolate reductase (mthfr) Phyre2 PDB 3tr9 chain A Region: 91 - 269 Aligned: 167 Modelled: 179 Confidence: 70.7% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:dihydropteroate synthase; PDBTitle: structure of a dihydropteroate synthase (folp) in complex with pteroic2 acid from coxiella burnetii Phyre2 PDB 6clu chain C Region: 89 - 269 Aligned: 156 Modelled: 175 Confidence: 63.3% Identity: 21% PDB header:antimicrobial protein Chain: C: PDB Molecule:dihydropteroate synthase; PDBTitle: staphylococcus aureus dihydropteroate synthase (sadhps) f17l e208k2 double mutant structure Phyre2 PDB 4i7v chain D Region: 93 - 227 Aligned: 129 Modelled: 135 Confidence: 61.5% Identity: 16% PDB header:biosynthetic protein Chain: D: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: agrobacterium tumefaciens dhdps with pyruvate Phyre2 PDB 3ug9 chain A Region: 146 - 222 Aligned: 74 Modelled: 77 Confidence: 55.9% Identity: 26% PDB header:membrane protein Chain: A: PDB Molecule:archaeal-type opsin 1, archaeal-type opsin 2; PDBTitle: crystal structure of the closed state of channelrhodopsin Phyre2 PDB 5ks8 chain D Region: 101 - 281 Aligned: 166 Modelled: 181 Confidence: 51.4% Identity: 16% PDB header:ligase Chain: D: PDB Molecule:pyruvate carboxylase subunit beta; PDBTitle: crystal structure of two-subunit pyruvate carboxylase from2 methylobacillus flagellatus Phyre2 PDB 3daq chain B Region: 93 - 229 Aligned: 134 Modelled: 137 Confidence: 51.0% Identity: 18% PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from methicillin-2 resistant staphylococcus aureus Phyre2 PDB 5ks8 chain F Region: 101 - 281 Aligned: 166 Modelled: 181 Confidence: 49.8% Identity: 16% PDB header:ligase Chain: F: PDB Molecule:pyruvate carboxylase subunit beta; PDBTitle: crystal structure of two-subunit pyruvate carboxylase from2 methylobacillus flagellatus Phyre2 PDB 3ler chain A Region: 93 - 227 Aligned: 129 Modelled: 135 Confidence: 45.1% Identity: 20% PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from campylobacter2 jejuni subsp. jejuni nctc 11168 Phyre2 PDB 3eef chain A Region: 12 - 121 Aligned: 105 Modelled: 107 Confidence: 43.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:n-carbamoylsarcosine amidase related protein; PDBTitle: crystal structure of n-carbamoylsarcosine amidase from thermoplasma2 acidophilum Phyre2 PDB 4n7b chain A Region: 62 - 122 Aligned: 59 Modelled: 61 Confidence: 42.7% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:lytb; PDBTitle: structure of the e-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate2 reductase from plasmodium falciparum Phyre2 PDB 1to0 chain A Region: 72 - 137 Aligned: 66 Modelled: 63 Confidence: 40.3% Identity: 17% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: YbeA-like Phyre2 PDB 1pda chain A domain 2 Region: 226 - 272 Aligned: 25 Modelled: 25 Confidence: 40.1% Identity: 32% Fold: dsRBD-like Superfamily: Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain Family: Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain Phyre2 PDB 1pjq chain A domain 3 Region: 266 - 298 Aligned: 31 Modelled: 33 Confidence: 40.0% Identity: 26% Fold: Siroheme synthase middle domains-like Superfamily: Siroheme synthase middle domains-like Family: Siroheme synthase middle domains-like Phyre2 PDB 2j0p chain A domain 1 Region: 60 - 127 Aligned: 68 Modelled: 68 Confidence: 38.6% Identity: 21% Fold: Heme iron utilization protein-like Superfamily: Heme iron utilization protein-like Family: HemS/ChuS-like Phyre2 1 c3ijdB_ 2 c6fnuA_ 3 d1v93a_ 4 d1b5ta_ 5 c2fmoA_ 6 c6fcxA_ 7 c3tr9A_ 8 c6cluC_ 9 c4i7vD_ 10 c3ug9A_ 11 c5ks8D_ 12 c3daqB_ 13 c5ks8F_ 14 c3lerA_ 15 c3eefA_ 16 c4n7bA_ 17 d1to0a_ 18 d1pdaa2 19 d1pjqa3 20 d2j0pa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99