1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	A	G	A	I	T	D	Q	L	R	R	Y	L	H	G	R	R	R	A	A	A	H	M	G	S	D	Y	D	G	L	I	A	D	L	E	D	F	V	L	G	G	G	K	R	L	R	P	L	F	A	Y	W	G	W	H	A	V	A	S	R
Secondary structure
SS confidence
Disorder		?	?	?																			?	?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	P	D	P	D	V	L	L	L	F	S	A	L	E	L	L	H	A	W	A	L	V	H	D	D	L	I	D	R	S	A	T	R	R	G	R	P	T	A	Q	L	R	Y	A	A	L	H	R	D	R	D	W	R	G	S	P	D	Q	F	G
Secondary structure
SS confidence
Disorder																																																?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	S	A	A	I	L	L	G	D	L	A	Q	V	W	A	D	D	I	V	S	K	V	C	Q	S	A	L	A	P	D	A	Q	R	R	V	H	R	V	W	A	D	I	R	N	E	V	L	G	G	Q	Y	L	D	I	V	A	E	A	S	A
Secondary structure
SS confidence
Disorder																										?	?	?	?																													?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	E	S	I	E	S	A	M	N	V	A	T	L	K	T	A	C	Y	T	V	S	R	P	L	Q	L	G	T	A	A	A	A	D	R	S	D	V	A	A	I	F	E	H	F	G	A	D	L	G	V	A	F	Q	L	R	D	D	V	L	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	F	G	D	P	A	V	T	G	K	P	S	G	D	D	L	K	S	G	K	R	T	V	L	V	A	E	A	V	E	L	A	D	R	S	D	P	L	A	A	K	L	L	R	T	S	I	G	T	R	L	T	D	A	Q	V	R	E	L	R
Secondary structure
SS confidence
Disorder																																			?	?	?												?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.
Sequence		T	V	I	E	A	V	G	A	R	A	A	A	E	S	R	I	A	A	L	T	Q	R	A	L	A	T	L	A	S	A	P	I	N	A	T	A	K	A	G	L	S	E	L	A	M	M	A	A	N	R	S	A
Secondary structure
SS confidence
Disorder																														?	?	?	?																	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 72%) Beta strand ( 0%) TM helix ( 9%) (View membrane topology prediction)

Rank Aligned region

PDB 3mzv chain B Region: 1 - 351 Aligned: 319 Modelled: 335 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: B: PDB Molecule:decaprenyl diphosphate synthase; PDBTitle: crystal structure of a decaprenyl diphosphate synthase from2 rhodobacter capsulatus Phyre2 PDB 1wy0 chain A Region: 1 - 351 Aligned: 322 Modelled: 335 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl pyrophosphate synthetase; PDBTitle: crystal structure of geranylgeranyl pyrophosphate synthetase from2 pyrococcus horikoshii ot3 Phyre2 PDB 3oyr chain B Region: 1 - 352 Aligned: 319 Modelled: 336 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: B: PDB Molecule:trans-isoprenyl diphosphate synthase; PDBTitle: crystal structure of polyprenyl synthase from caulobacter crescentus2 cb15 complexed with calcium and isoprenyl diphosphate Phyre2 PDB 3nf2 chain A Region: 1 - 348 Aligned: 324 Modelled: 332 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:putative polyprenyl synthetase; PDBTitle: crystal structure of polyprenyl synthetase from streptomyces2 coelicolor a3(2) Phyre2 PDB 5h9d chain B Region: 2 - 352 Aligned: 317 Modelled: 335 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:farnesyl pyrophosphate synthetase; PDBTitle: crystal structure of heptaprenyl diphosphate synthase from2 staphylococcus aureus Phyre2 PDB 3aqb chain D Region: 1 - 351 Aligned: 319 Modelled: 335 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: D: PDB Molecule:component b of hexaprenyl diphosphate synthase; PDBTitle: m. luteus b-p 26 heterodimeric hexaprenyl diphosphate synthase in2 complex with magnesium Phyre2 PDB 1wmw chain A Region: 4 - 350 Aligned: 316 Modelled: 331 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl diphosphate synthetase; PDBTitle: crystal structure of geranulgeranyl diphosphate synthase from thermus2 thermophilus Phyre2 PDB 1fps chain A Region: 6 - 351 Aligned: 321 Modelled: 330 Confidence: 100.0% Identity: 23% Fold: Terpenoid synthases Superfamily: Terpenoid synthases Family: Isoprenyl diphosphate synthases Phyre2 PDB 6b07 chain B Region: 2 - 351 Aligned: 325 Modelled: 331 Confidence: 100.0% Identity: 20% PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:farnesyl diphosphate synthase; PDBTitle: crystal structure of cffpps2, a lepidopteran type-ii farnesyl2 diphosphate synthase, complexed with [1-phosphono-2-(1-propylpyridin-3 2-yl)ethyl]phosphonic acid (inhibitor 1d) Phyre2 PDB 4kk2 chain B Region: 5 - 351 Aligned: 322 Modelled: 331 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: B: PDB Molecule:monoterpene synthase fds-5, chloroplastic - farnesyl PDBTitle: crystal structure of a chimeric fpp/gfpp synthase (target efi-502313c)2 from artemisia spiciformis (1-72:gi751454468,73-346:gi75233326), apo3 structure Phyre2 PDB 5jfq chain B Region: 5 - 350 Aligned: 304 Modelled: 330 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: B: PDB Molecule:geranylgeranyl pyrophosphate synthetase; PDBTitle: geranylgeranyl pyrophosphate synthetase from archaeon geoglobus2 acetivorans Phyre2 PDB 4jzb chain A Region: 4 - 351 Aligned: 326 Modelled: 334 Confidence: 100.0% Identity: 24% PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:farnesyl pyrophosphate synthase; PDBTitle: crystal structure of leshmaniasis major farnesyl diphosphate synthase2 in complex with 1-(2-hydroxy-2,2-diphosphonoethyl)-3-3 phenylpyridinium, ipp and ca2+ Phyre2 PDB 3lk5 chain A Region: 1 - 349 Aligned: 317 Modelled: 320 Confidence: 100.0% Identity: 44% PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl pyrophosphate synthase; PDBTitle: crystal structure of putative geranylgeranyl pyrophosphate synthase2 from corynebacterium glutamicum Phyre2 PDB 3cp6 chain A Region: 7 - 347 Aligned: 316 Modelled: 322 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:farnesyl pyrophosphate synthetase; PDBTitle: crystal structure of human farnesyl diphosphate synthase (t201a2 mutant) complexed with mg and biphosphonate inhibitor Phyre2 PDB 4lob chain A Region: 1 - 350 Aligned: 301 Modelled: 320 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:polyprenyl synthetase; PDBTitle: crystal structure of polyprenyl diphosphate synthase a1s_2732 (target2 efi-509223) from acinetobacter baumannii Phyre2 PDB 2f94 chain F Region: 4 - 347 Aligned: 318 Modelled: 328 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: F: PDB Molecule:farnesyl diphosphate synthase; PDBTitle: crystal structure of human fpps in complex with ibandronate Phyre2 PDB 2ogd chain B Region: 4 - 351 Aligned: 326 Modelled: 334 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:farnesyl pyrophosphate synthase; PDBTitle: t. brucei farnesyl diphosphate synthase complexed with bisphosphonate2 bph-527 Phyre2 PDB 3wjn chain A Region: 1 - 348 Aligned: 301 Modelled: 332 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:octaprenyl diphosphate synthase; PDBTitle: crystal structure of octaprenyl pyrophosphate synthase from2 escherichia coli with farnesyl s-thiol-pyrophosphate (fspp) Phyre2 PDB 1yhl chain A Region: 4 - 351 Aligned: 326 Modelled: 334 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:farnesyl pyrophosphate synthase; PDBTitle: structure of the complex of trypanosoma cruzi farnesyl diphosphate2 synthase with risedronate, dmapp and mg+2 Phyre2 PDB 3ez3 chain A Region: 4 - 349 Aligned: 323 Modelled: 330 Confidence: 100.0% Identity: 22% PDB header:lyase Chain: A: PDB Molecule:farnesyl pyrophosphate synthase, putative; PDBTitle: crystal structure of plasmodium vivax geranylgeranylpyrophosphate2 synthase pvx_092040 with zoledronate and ipp bound Phyre2 1 c3mzvB_ 2 c1wy0A_ 3 c3oyrB_ 4 c3nf2A_ 5 c5h9dB_ 6 c3aqbD_ 7 c1wmwA_ 8 d1fpsa_ 9 c6b07B_ 10 c4kk2B_ 11 c5jfqB_ 12 c4jzbA_ 13 c3lk5A_ 14 c3cp6A_ 15 c4lobA_ 16 c2f94F_ 17 c2ogdB_ 18 c3wjnA_ 19 c1yhlA_ 20 c3ez3A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99