1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	P	S	H	A	P	A	V	D	L	A	T	A	K	D	A	V	V	Q	H	L	S	R	L	F	E	F	T	T	G	P	Q	G	G	P	A	R	L	G	F	A	G	A	V	L	I	T	A	G	G	L	G	A	G	S	V	R	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?	?																				?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	D	P	L	L	E	S	I	H	M	S	W	L	R	F	G	H	G	L	V	L	S	S	I	L	L	W	T	G	V	G	V	M	L	L	A	W	L	G	L	G	R	R	V	L	A	G	E	A	T	E	F	T	M	R	A	T	T	V	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?				?	?																																	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		W	L	A	P	L	L	L	S	V	P	V	F	S	R	D	T	Y	S	Y	L	A	Q	G	A	L	L	R	D	G	L	D	P	Y	A	V	G	P	V	G	N	P	N	A	L	L	D	D	V	S	P	I	W	T	I	T	T	A	P	Y	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	A	F	I	L	V	A	K	F	V	T	V	I	V	G	N	N	V	V	A	G	T	M	L	L	R	L	C	M	L	P	G	L	A	L	L	V	W	A	T	P	R	L	A	S	H	L	G	T	H	G	P	T	A	L	W	I	C	V	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	P	L	V	L	I	H	L	M	G	G	V	H	N	E	M	L	M	V	G	L	M	T	A	G	I	A	L	T	V	Q	G	R	N	V	A	G	I	I	L	I	T	V	A	I	A	V	K	A	T	A	G	I	A	L	P	F	L	V	W
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	W	L	R	H	L	R	E	R	R	G	Y	R	P	V	Q	A	F	L	A	A	A	A	I	S	L	L	I	F	V	A	V	F	A	V	L	S	A	V	A	G	V	G	L	G	W	L	T	A	L	A	G	S	V	K	I	I	N	W	L
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?																												?												?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		T	V	P	T	G	A	A	N	V	I	H	A	L	G	R	G	L	F	T	V	D	F	Y	T	L	L	R	I	T	R	L	I	G	I	V	I	I	A	V	S	L	P	L	L	W	W	R	F	R	R	D	D	R	A	A	L	T	G	V	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		W	S	M	L	I	V	V	L	F	V	P	A	A	L	P	W	Y	Y	S	W	P	L	A	V	A	A	P	L	A	Q	A	R	R	A	I	A	A	I	A	G	L	S	T	W	V	M	V	I	F	K	P	D	G	S	H	G	M	Y	S	W
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.
Sequence		L	H	F	W	I	A	T	A	C	A	L	T	A	W	Y	V	L	Y	R	S	P	D	R	R	G	V	Q	A	A	T	P	V	V	N	T	P
Secondary structure
SS confidence
Disorder																				?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 70%) Beta strand ( 0%) TM helix ( 54%) (View membrane topology prediction)

Rank Aligned region

PDB 5f15 chain A Region: 114 - 503 Aligned: 355 Modelled: 374 Confidence: 99.3% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:4-amino-4-deoxy-l-arabinose (l-ara4n) transferase; PDBTitle: crystal structure of arnt from cupriavidus metallidurans bound to2 undecaprenyl phosphate Phyre2 PDB 6p25 chain A Region: 176 - 341 Aligned: 165 Modelled: 166 Confidence: 98.4% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 1; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor and a peptide acceptor Phyre2 PDB 6p2r chain B Region: 111 - 341 Aligned: 207 Modelled: 208 Confidence: 98.3% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 2; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor Phyre2 PDB 3waj chain A Region: 131 - 448 Aligned: 309 Modelled: 318 Confidence: 98.1% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:transmembrane oligosaccharyl transferase; PDBTitle: crystal structure of the archaeoglobus fulgidus2 oligosaccharyltransferase (o29867_arcfu) complex with zn and sulfate Phyre2 PDB 3rce chain A Region: 131 - 471 Aligned: 319 Modelled: 321 Confidence: 95.8% Identity: 10% PDB header:transferase/peptide Chain: A: PDB Molecule:oligosaccharide transferase to n-glycosylate proteins; PDBTitle: bacterial oligosaccharyltransferase pglb Phyre2 PDB 6ezn chain F Region: 133 - 448 Aligned: 307 Modelled: 316 Confidence: 77.4% Identity: 8% PDB header:membrane protein Chain: F: PDB Molecule:dolichyl-diphosphooligosaccharide--protein PDBTitle: cryo-em structure of the yeast oligosaccharyltransferase (ost) complex Phyre2 PDB 1ynj chain D domain 1 Region: 430 - 438 Aligned: 9 Modelled: 9 Confidence: 20.2% Identity: 44% Fold: beta and beta-prime subunits of DNA dependent RNA-polymerase Superfamily: beta and beta-prime subunits of DNA dependent RNA-polymerase Family: RNA-polymerase beta-prime Phyre2 PDB 1zxo chain A domain 1 Region: 148 - 160 Aligned: 13 Modelled: 13 Confidence: 16.4% Identity: 15% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: BadF/BadG/BcrA/BcrD-like Phyre2 PDB 3e1k chain D Region: 134 - 144 Aligned: 11 Modelled: 7 Confidence: 15.7% Identity: 27% PDB header:transcription Chain: D: PDB Molecule:lactose regulatory protein lac9; PDBTitle: crystal structure of kluyveromyces lactis gal80p in complex with the2 acidic activation domain of gal4p Phyre2 PDB 3e1k chain F Region: 134 - 144 Aligned: 11 Modelled: 7 Confidence: 15.7% Identity: 27% PDB header:transcription Chain: F: PDB Molecule:lactose regulatory protein lac9; PDBTitle: crystal structure of kluyveromyces lactis gal80p in complex with the2 acidic activation domain of gal4p Phyre2 PDB 3e1k chain P Region: 134 - 144 Aligned: 11 Modelled: 7 Confidence: 15.7% Identity: 27% PDB header:transcription Chain: P: PDB Molecule:lactose regulatory protein lac9; PDBTitle: crystal structure of kluyveromyces lactis gal80p in complex with the2 acidic activation domain of gal4p Phyre2 PDB 3e1k chain B Region: 134 - 144 Aligned: 11 Modelled: 7 Confidence: 15.7% Identity: 27% PDB header:transcription Chain: B: PDB Molecule:lactose regulatory protein lac9; PDBTitle: crystal structure of kluyveromyces lactis gal80p in complex with the2 acidic activation domain of gal4p Phyre2 PDB 3e1k chain L Region: 134 - 144 Aligned: 11 Modelled: 7 Confidence: 15.7% Identity: 27% PDB header:transcription Chain: L: PDB Molecule:lactose regulatory protein lac9; PDBTitle: crystal structure of kluyveromyces lactis gal80p in complex with the2 acidic activation domain of gal4p Phyre2 PDB 3e1k chain J Region: 134 - 144 Aligned: 11 Modelled: 7 Confidence: 15.7% Identity: 27% PDB header:transcription Chain: J: PDB Molecule:lactose regulatory protein lac9; PDBTitle: crystal structure of kluyveromyces lactis gal80p in complex with the2 acidic activation domain of gal4p Phyre2 PDB 3e1k chain H Region: 134 - 144 Aligned: 11 Modelled: 7 Confidence: 15.7% Identity: 27% PDB header:transcription Chain: H: PDB Molecule:lactose regulatory protein lac9; PDBTitle: crystal structure of kluyveromyces lactis gal80p in complex with the2 acidic activation domain of gal4p Phyre2 PDB 3e1k chain N Region: 134 - 144 Aligned: 11 Modelled: 7 Confidence: 15.7% Identity: 27% PDB header:transcription Chain: N: PDB Molecule:lactose regulatory protein lac9; PDBTitle: crystal structure of kluyveromyces lactis gal80p in complex with the2 acidic activation domain of gal4p Phyre2 PDB 4g7o chain N Region: 431 - 438 Aligned: 8 Modelled: 8 Confidence: 15.2% Identity: 50% PDB header:transcription, transferase/dna Chain: N: PDB Molecule:dna-directed rna polymerase subunit beta'; PDBTitle: crystal structure of thermus thermophilus transcription initiation2 complex containing 2 nt of rna Phyre2 PDB 5xj0 chain D Region: 431 - 438 Aligned: 8 Modelled: 8 Confidence: 15.1% Identity: 50% PDB header:transferase/transcription Chain: D: PDB Molecule:dna-directed rna polymerase subunit beta'; PDBTitle: t. thermophilus rna polymerase holoenzyme bound with gp39 and gp76 Phyre2 PDB 3fmt chain F Region: 133 - 141 Aligned: 9 Modelled: 9 Confidence: 13.9% Identity: 44% PDB header:replication inhibitor/dna Chain: F: PDB Molecule:protein seqa; PDBTitle: crystal structure of seqa bound to dna Phyre2 PDB 5x22 chain D Region: 431 - 438 Aligned: 8 Modelled: 8 Confidence: 13.5% Identity: 50% PDB header:transferase/dna Chain: D: PDB Molecule:dna-directed rna polymerase subunit beta'; PDBTitle: crystal structure of thermus thermophilus transcription initiation2 complex with gpa and cmpcpp Phyre2 1 c5f15A_ 2 c6p25A_ 3 c6p2rB_ 4 c3wajA_ 5 c3rceA_ 6 c6eznF_ 7 d1ynjd1 8 d1zxoa1 9 c3e1kD_ 10 c3e1kF_ 11 c3e1kP_ 12 c3e1kB_ 13 c3e1kL_ 14 c3e1kJ_ 15 c3e1kH_ 16 c3e1kN_ 17 c4g7oN_ 18 c5xj0D_ 19 c3fmtF_ 20 c5x22D_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99