1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	W	T	V	D	I	P	I	D	Q	L	P	S	L	P	P	L	P	T	D	L	R	T	R	L	D	A	A	L	A	K	P	A	A	Q	Q	P	T	W	P	A	D	Q	A	L	A	M	R	T	V	L	E	S	V	P	P	V	T	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?															?	?	?	?		?																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	S	E	I	V	R	L	Q	E	Q	L	A	Q	V	A	K	G	E	A	F	L	L	Q	G	G	D	C	A	E	T	F	M	D	N	T	E	P	H	I	R	G	N	V	R	A	L	L	Q	M	A	V	V	L	T	Y	G	A	S	M	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	V	K	V	A	R	I	A	G	Q	Y	A	K	P	R	S	A	D	I	D	A	L	G	L	R	S	Y	R	G	D	M	I	N	G	F	A	P	D	A	A	A	R	E	H	D	P	S	R	L	V	R	A	Y	A	N	A	S	A	A	M
Secondary structure
SS confidence
Disorder																																								?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		N	L	V	R	A	L	T	S	S	G	L	A	S	L	H	L	V	H	D	W	N	R	E	F	V	R	T	S	P	A	G	A	R	Y	E	A	L	A	T	E	I	D	R	G	L	R	F	M	S	A	C	G	V	A	D	R	N	L	Q	T
Secondary structure
SS confidence
Disorder							?			?	?	?	?	?	?												?	?	?	?	?	?																					?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	E	I	Y	A	S	H	E	A	L	V	L	D	Y	E	R	A	M	L	R	L	S	D	G	D	D	G	E	P	Q	L	F	D	L	S	A	H	T	V	W	I	G	E	R	T	R	Q	I	D	G	A	H	I	A	F	A	Q	V	I	A
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		N	P	V	G	V	K	L	G	P	N	M	T	P	E	L	A	V	E	Y	V	E	R	L	D	P	H	N	K	P	G	R	L	T	L	V	S	R	M	G	N	H	K	V	R	D	L	L	P	P	I	V	E	K	V	Q	A	T	G	H	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	I	W	Q	C	D	P	M	H	G	N	T	H	E	S	S	T	G	F	K	T	R	H	F	D	R	I	V	D	E	V	Q	G	F	F	E	V	H	R	A	L	G	T	H	P	G	G	I	H	V	E	I	T	G	E	N	V	T	E	C
Secondary structure
SS confidence
Disorder															?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.
Sequence		L	G	G	A	Q	D	I	S	E	T	D	L	A	G	R	Y	E	T	A	C	D	P	R	L	N	T	Q	Q	S	L	E	L	A	F	L	V	A	E	M	L	R	D
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?																														?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 42%) Beta strand ( 11%)

Rank Aligned region

PDB 2b7o chain A domain 1 Region: 1 - 462 Aligned: 449 Modelled: 461 Confidence: 100.0% Identity: 97% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class-II DAHP synthetase Phyre2 PDB 5hud chain A Region: 19 - 462 Aligned: 444 Modelled: 444 Confidence: 100.0% Identity: 66% PDB header:transferase/isomerase Chain: A: PDB Molecule:3-deoxy-d-arabino-heptulosonate 7-phosphate (dahp) PDBTitle: non-covalent complex of and dahp synthase and chorismate mutase from2 corynebacterium glutamicum with bound transition state analog Phyre2 PDB 5uxm chain A Region: 31 - 462 Aligned: 429 Modelled: 432 Confidence: 100.0% Identity: 50% PDB header:transferase Chain: A: PDB Molecule:phospho-2-dehydro-3-deoxyheptonate aldolase; PDBTitle: type ii dah7ps from pseudomonas aeruginosa with trp bound Phyre2 PDB 6bmc chain A Region: 22 - 457 Aligned: 379 Modelled: 389 Confidence: 100.0% Identity: 42% PDB header:transferase Chain: A: PDB Molecule:phospho-2-dehydro-3-deoxyheptonate aldolase; PDBTitle: the structure of a dimeric type ii dah7ps associated with pyocyanin2 biosynthesis in pseudomonas aeruginosa Phyre2 PDB 4hsn chain A Region: 51 - 461 Aligned: 299 Modelled: 336 Confidence: 98.5% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:3-deoxy-d-arabino-heptulosonate 7-phosphate synthase; PDBTitle: crystal structure of dah7ps from neisseria meningitidis Phyre2 PDB 1n8f chain A Region: 265 - 461 Aligned: 182 Modelled: 191 Confidence: 98.3% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I DAHP synthetase Phyre2 PDB 1of8 chain A Region: 51 - 461 Aligned: 294 Modelled: 294 Confidence: 98.2% Identity: 23% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I DAHP synthetase Phyre2 PDB 3tqk chain A Region: 127 - 461 Aligned: 235 Modelled: 259 Confidence: 98.2% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:phospho-2-dehydro-3-deoxyheptonate aldolase; PDBTitle: structure of phospho-2-dehydro-3-deoxyheptonate aldolase from2 francisella tularensis schu s4 Phyre2 PDB 1ofa chain B Region: 265 - 461 Aligned: 171 Modelled: 197 Confidence: 98.0% Identity: 25% PDB header:lyase Chain: B: PDB Molecule:phospho-2-dehydro-3-deoxyheptonate aldolase; PDBTitle: crystal structure of the tyrosine-regulated2 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase3 from saccharomyces cerevisiae in complex with4 phosphoenolpyruvate and cobalt(ii) Phyre2 PDB 6agm chain A Region: 265 - 461 Aligned: 164 Modelled: 174 Confidence: 97.9% Identity: 23% PDB header:biosynthetic protein Chain: A: PDB Molecule:phospho-2-dehydro-3-deoxyheptonate aldolase, tyr-sensitive; PDBTitle: molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-2 d-arabino-heptulosonate-7-phosphate synthase from escherichia coli Phyre2 PDB 4lu0 chain A Region: 278 - 401 Aligned: 119 Modelled: 123 Confidence: 96.6% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:2-dehydro-3-deoxyphosphooctonate aldolase; PDBTitle: crystal structure of 2-keto-3-deoxy-d-manno-octulosonate-8-phosphate2 synthase from pseudomonas aeruginosa. Phyre2 PDB 1zco chain A Region: 278 - 371 Aligned: 91 Modelled: 94 Confidence: 95.9% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:2-dehydro-3-deoxyphosphoheptonate aldolase; PDBTitle: crystal structure of pyrococcus furiosus 3-deoxy-d-arabino-2 heptulosonate 7-phosphate synthase Phyre2 PDB 6mdy chain C Region: 278 - 375 Aligned: 93 Modelled: 98 Confidence: 95.8% Identity: 14% PDB header:hydrolase Chain: C: PDB Molecule:2-dehydro-3-deoxyphosphooctonate aldolase; PDBTitle: crystal structure of a 2-dehydro-3-deoxyphosphooctonate aldolase from2 legionella pneumophila philadelphia 1 Phyre2 PDB 1vs1 chain B Region: 278 - 374 Aligned: 94 Modelled: 97 Confidence: 95.7% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:3-deoxy-7-phosphoheptulonate synthase; PDBTitle: crystal structure of 3-deoxy-d-arabino-heptulosonate-7-2 phosphate synthase (dahp synthase) from aeropyrum pernix3 in complex with mn2+ and pep Phyre2 PDB 1vr6 chain A domain 1 Region: 278 - 375 Aligned: 95 Modelled: 96 Confidence: 93.6% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I DAHP synthetase Phyre2 PDB 3stg chain A Region: 278 - 371 Aligned: 91 Modelled: 94 Confidence: 93.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:2-dehydro-3-deoxyphosphooctonate aldolase; PDBTitle: crystal structure of a58p, del(n59), and loop 7 truncated mutant of 3-2 deoxy-d-manno-octulosonate 8-phosphate synthase (kdo8ps) from3 neisseria meningitidis Phyre2 PDB 2a21 chain A domain 1 Region: 278 - 400 Aligned: 121 Modelled: 123 Confidence: 90.6% Identity: 21% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I DAHP synthetase Phyre2 PDB 3nvt chain A Region: 278 - 366 Aligned: 88 Modelled: 89 Confidence: 88.5% Identity: 16% PDB header:transferase/isomerase Chain: A: PDB Molecule:3-deoxy-d-arabino-heptulosonate 7-phosphate synthase; PDBTitle: 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7-2 phosphoheptulonate synthase/chorismate mutase (aroa) from listeria3 monocytogenes egd-e Phyre2 PDB 3s6o chain D Region: 316 - 407 Aligned: 79 Modelled: 87 Confidence: 88.1% Identity: 18% PDB header:hydrolase Chain: D: PDB Molecule:polysaccharide deacetylase family protein; PDBTitle: crystal structure of a polysaccharide deacetylase family protein from2 burkholderia pseudomallei Phyre2 PDB 1d9e chain A Region: 278 - 371 Aligned: 91 Modelled: 94 Confidence: 86.6% Identity: 9% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I DAHP synthetase Phyre2 1 d2b7oa1 2 c5hudA_ 3 c5uxmA_ 4 c6bmcA_ 5 c4hsnA_ 6 d1n8fa_ 7 d1of8a_ 8 c3tqkA_ 9 c1ofaB_ 10 c6agmA_ 11 c4lu0A_ 12 c1zcoA_ 13 c6mdyC_ 14 c1vs1B_ 15 d1vr6a1 16 c3stgA_ 17 d2a21a1 18 c3nvtA_ 19 c3s6oD_ 20 d1d9ea_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99