1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	W	R	A	P	E	V	G	S	R	L	G	R	R	V	L	W	C	L	L	W	L	L	A	G	V	A	L	G	Y	V	A	W	R	L	F	G	H	T	P	Y	R	I	D	I	D	I	Y	Q	M	G	A	R	A	W	L	D	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	P	L	Y	G	G	G	V	L	F	H	T	P	I	G	L	N	L	P	F	T	Y	P	P	L	A	A	V	L	F	S	P	F	A	W	L	Q	M	P	A	A	S	V	A	I	T	V	L	T	L	V	L	L	I	A	S	T	A	I	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	T	G	L	D	A	W	P	T	S	R	L	V	P	A	P	A	R	L	R	R	L	W	L	A	V	L	I	V	A	P	A	T	I	W	L	E	P	I	S	S	N	F	A	F	G	Q	I	N	V	V	L	M	T	L	V	I	V	D	C
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	P	R	R	T	P	W	P	R	G	L	M	L	G	L	G	I	A	L	K	L	T	P	A	V	F	L	L	Y	F	L	L	R	R	D	G	R	A	A	L	T	A	L	A	S	F	A	V	A	T	L	L	G	F	V	L	A	W	R	D
Secondary structure
SS confidence
Disorder				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	W	E	Y	W	T	H	T	L	H	H	T	D	R	I	G	A	A	A	L	N	T	D	Q	N	I	A	G	A	L	A	R	L	T	I	G	D	D	E	R	F	A	L	W	V	A	G	S	L	L	V	L	A	A	T	I	W	A	M	R
Secondary structure
SS confidence
Disorder																?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		R	V	L	R	A	G	E	P	T	L	A	V	I	C	V	A	L	F	G	L	V	V	S	P	V	S	W	S	H	H	W	V	W	M	L	P	A	V	L	V	I	G	L	L	G	W	R	R	R	N	V	A	L	A	M	L	S	L	A	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	V	L	M	R	W	T	P	I	D	L	L	P	Q	H	R	E	T	T	A	V	W	W	R	Q	L	A	G	M	S	Y	V	W	W	A	L	A	V	I	V	V	A	G	L	T	V	T	A	R	M	T	P	Q	R	S	L	T	R	G	L
Secondary structure
SS confidence
Disorder											?				?																																?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.
Sequence		T	P	A	P	T	A	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 70%) Beta strand ( 0%) TM helix ( 52%) (View membrane topology prediction)

Rank Aligned region

PDB 5f15 chain A Region: 22 - 414 Aligned: 359 Modelled: 377 Confidence: 98.3% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:4-amino-4-deoxy-l-arabinose (l-ara4n) transferase; PDBTitle: crystal structure of arnt from cupriavidus metallidurans bound to2 undecaprenyl phosphate Phyre2 PDB 6p25 chain A Region: 11 - 265 Aligned: 223 Modelled: 224 Confidence: 98.3% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 1; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor and a peptide acceptor Phyre2 PDB 6p2r chain B Region: 15 - 265 Aligned: 220 Modelled: 220 Confidence: 98.2% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 2; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor Phyre2 PDB 3waj chain A Region: 17 - 386 Aligned: 352 Modelled: 353 Confidence: 44.4% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:transmembrane oligosaccharyl transferase; PDBTitle: crystal structure of the archaeoglobus fulgidus2 oligosaccharyltransferase (o29867_arcfu) complex with zn and sulfate Phyre2 PDB 5c77 chain B Region: 39 - 83 Aligned: 43 Modelled: 45 Confidence: 25.6% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:protein arginine n-methyltransferase sfm1; PDBTitle: a novel protein arginine methyltransferase Phyre2 PDB 2zkr chain Y Region: 1 - 16 Aligned: 16 Modelled: 16 Confidence: 9.0% Identity: 38% PDB header:ribosomal protein/rna Chain: Y: PDB Molecule:5s ribosomal rna; PDBTitle: structure of a mammalian ribosomal 60s subunit within an 80s complex2 obtained by docking homology models of the rna and proteins into an3 8.7 a cryo-em map Phyre2 PDB 5d6h chain B Region: 45 - 55 Aligned: 11 Modelled: 11 Confidence: 7.5% Identity: 45% PDB header:chaperone/protein transport Chain: B: PDB Molecule:csua/b; PDBTitle: crystal structure of csuc-csua/b chaperone-major subunit pre-assembly2 complex from csu biofilm-mediating pili of acinetobacter baumannii Phyre2 PDB 3dwq chain D Region: 47 - 89 Aligned: 32 Modelled: 43 Confidence: 7.0% Identity: 34% PDB header:toxin Chain: D: PDB Molecule:subtilase cytotoxin, subunit b; PDBTitle: crystal structure of the a-subunit of the ab5 toxin from e.2 coli with neu5gc-2,3gal-1,3glcnac Phyre2 PDB 4k6l chain C Region: 47 - 89 Aligned: 32 Modelled: 43 Confidence: 5.7% Identity: 22% PDB header:toxin Chain: C: PDB Molecule:putative pertussis-like toxin subunit; PDBTitle: structure of typhoid toxin Phyre2 PDB 5whv chain F Region: 47 - 89 Aligned: 32 Modelled: 43 Confidence: 5.6% Identity: 25% PDB header:toxin Chain: F: PDB Molecule:artb protein; PDBTitle: crystal structure of artb Phyre2 PDB 2f69 chain A domain 1 Region: 59 - 83 Aligned: 25 Modelled: 25 Confidence: 5.6% Identity: 28% Fold: open-sided beta-meander Superfamily: Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Family: Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Phyre2 1 c5f15A_ 2 c6p25A_ 3 c6p2rB_ 4 c3wajA_ 5 c5c77B_ 6 c2zkry_ 7 c5d6hB_ 8 c3dwqD_ 9 c4k6lC_ 10 c5whvF_ 11 d2f69a1