1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	D	G	P	A	A	P	A	Q	V	V	A	P	A	D	G	F	V	A	L	R	V	A	D	D	R	T	V	R	L	L	S	L	G	G	A	A	T	D	R	L	L	S	R	I	A	A	G	I	D	A	A	V	D	E	V	V	A	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		W	G	T	D	W	S	H	D	I	F	V	V	A	A	G	S	D	E	Q	F	H	A	A	A	G	G	G	L	A	S	Q	W	A	D	I	A	A	I	T	V	V	D	R	V	D	P	A	R	R	T	V	V	G	Q	R	I	V	F	A	P
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	A	A	H	M	S	P	A	A	L	R	I	V	L	G	H	E	L	F	H	Y	A	A	R	A	D	T	A	L	D	A	P	R	W	L	A	E	G	V	A	D	F	V	A	R	P	K	T	P	P	P	A	D	A	V	S	V	A	L	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?		?																																				?	?		?					?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	P	S	D	T	D	L	D	T	P	G	P	Q	R	S	L	A	Y	D	R	A	W	W	F	A	R	F	V	A	A	A	Y	G	T	A	K	L	R	E	L	Y	L	A	T	C	G	V	G	H	F	D	L	A	T	A	A	H	D	V	L
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?																																		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.
Sequence		G	I	D	A	A	G	L	L	A	R	W	Q	R	W	L	M	G
Secondary structure
SS confidence
Disorder																?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 48%) Beta strand ( 9%)

Rank Aligned region

PDB 4ar9 chain A Region: 20 - 255 Aligned: 220 Modelled: 223 Confidence: 99.6% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:collagenase colt; PDBTitle: crystal structure of the peptidase domain of collagenase t2 from clostridium tetani at 1.69 angstrom resolution. Phyre2 PDB 4ar1 chain A Region: 18 - 255 Aligned: 223 Modelled: 227 Confidence: 99.6% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:colh protein; PDBTitle: crystal structure of the peptidase domain of collagenase h from2 clostridium histolyticum at 2.01 angstrom resolution. Phyre2 PDB 3qnf chain C Region: 15 - 253 Aligned: 216 Modelled: 239 Confidence: 99.5% Identity: 13% PDB header:hydrolase Chain: C: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the open state of human endoplasmic reticulum2 aminopeptidase 1 erap1 Phyre2 PDB 3qnf chain A Region: 15 - 251 Aligned: 214 Modelled: 237 Confidence: 99.5% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the open state of human endoplasmic reticulum2 aminopeptidase 1 erap1 Phyre2 PDB 4gaa chain A Region: 28 - 257 Aligned: 202 Modelled: 202 Confidence: 99.5% Identity: 12% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:mgc78867 protein; PDBTitle: structure of leukotriene a4 hydrolase from xenopus laevis complexed2 with inhibitor bestatin Phyre2 PDB 4kxd chain A Region: 15 - 251 Aligned: 216 Modelled: 225 Confidence: 99.5% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:glutamyl aminopeptidase; PDBTitle: crystal structure of human aminopeptidase a complexed with glutamate2 and calcium Phyre2 PDB 2y50 chain A Region: 20 - 255 Aligned: 221 Modelled: 236 Confidence: 99.4% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:collagenase; PDBTitle: crystal structure of collagenase g from clostridium2 histolyticum at 2.80 angstrom resolution Phyre2 PDB 2xdt chain A Region: 15 - 251 Aligned: 215 Modelled: 224 Confidence: 99.4% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: crystal structure of the soluble domain of human2 endoplasmic reticulum aminopeptidase 1 erap1 Phyre2 PDB 3b7u chain X Region: 28 - 255 Aligned: 200 Modelled: 200 Confidence: 99.4% Identity: 14% PDB header:hydrolase Chain: X: PDB Molecule:leukotriene a-4 hydrolase; PDBTitle: leukotriene a4 hydrolase complexed with kelatorphan Phyre2 PDB 2gtq chain A Region: 25 - 251 Aligned: 206 Modelled: 215 Confidence: 99.4% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of aminopeptidase n from human pathogen neisseria2 meningitidis Phyre2 PDB 3cia chain A Region: 27 - 251 Aligned: 197 Modelled: 197 Confidence: 99.4% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:cold-active aminopeptidase; PDBTitle: crystal structure of cold-aminopeptidase from colwellia2 psychrerythraea Phyre2 PDB 3mdj chain B Region: 15 - 251 Aligned: 214 Modelled: 225 Confidence: 99.4% Identity: 12% PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:endoplasmic reticulum aminopeptidase 1; PDBTitle: er aminopeptidase, erap1, bound to the zinc aminopeptidase inhibitor,2 bestatin Phyre2 PDB 5dll chain A Region: 26 - 251 Aligned: 205 Modelled: 214 Confidence: 99.4% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: aminopeptidase n (pepn) from francisella tularensis subsp. tularensis2 schu s4 Phyre2 PDB 3b37 chain A Region: 26 - 251 Aligned: 205 Modelled: 226 Confidence: 99.4% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of e. coli aminopeptidase n in complex with tyrosine Phyre2 PDB 5zi7 chain A Region: 26 - 251 Aligned: 205 Modelled: 226 Confidence: 99.4% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of legionella pneumophila aminopeptidase a in2 complex with glutamic acid Phyre2 PDB 5fur chain I Region: 22 - 251 Aligned: 207 Modelled: 215 Confidence: 99.4% Identity: 11% PDB header:transcription Chain: I: PDB Molecule:transcription initiation factor tfiid subunit 2; PDBTitle: structure of human tfiid-iia bound to core promoter dna Phyre2 PDB 3b7s chain A domain 3 Region: 28 - 255 Aligned: 200 Modelled: 200 Confidence: 99.3% Identity: 13% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Leukotriene A4 hydrolase catalytic domain Phyre2 PDB 1z5h chain B Region: 26 - 253 Aligned: 207 Modelled: 207 Confidence: 99.3% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:tricorn protease interacting factor f3; PDBTitle: crystal structures of the tricorn interacting factor f3 from2 thermoplasma acidophilum Phyre2 PDB 6a8z chain B Region: 26 - 253 Aligned: 193 Modelled: 199 Confidence: 99.3% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:zinc metalloprotease, putative; PDBTitle: crystal structure of m1 zinc metallopeptidase from deinococcus2 radiodurans Phyre2 PDB 3se6 chain A Region: 15 - 251 Aligned: 216 Modelled: 225 Confidence: 99.3% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 2; PDBTitle: crystal structure of the human endoplasmic reticulum aminopeptidase 2 Phyre2 1 c4ar9A_ 2 c4ar1A_ 3 c3qnfC_ 4 c3qnfA_ 5 c4gaaA_ 6 c4kxdA_ 7 c2y50A_ 8 c2xdtA_ 9 c3b7uX_ 10 c2gtqA_ 11 c3ciaA_ 12 c3mdjB_ 13 c5dllA_ 14 c3b37A_ 15 c5zi7A_ 16 c5furI_ 17 d3b7sa3 18 c1z5hB_ 19 c6a8zB_ 20 c3se6A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108