1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	R	A	D	D	D	A	V	G	V	P	P	T	C	G	G	R	S	D	E	E	E	R	R	I	V	P	G	P	N	P	Q	D	G	A	K	D	G	A	K	A	T	A	V	P	R	E	P	D	E	A	A	L	A	A	M	S	N	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	L	L	A	L	G	G	K	L	D	G	V	R	I	A	Y	K	E	P	R	W	P	V	E	G	T	K	A	E	K	R	A	E	R	S	V	A	V	W	L	L	L	G	G	V	F	G	L	A	L	L	L	I	F	L	F	W	P	W	E
Secondary structure
SS confidence
Disorder				?	?	?			?	?	?	?	?	?		?							?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	K	A	A	D	G	E	S	D	F	I	Y	S	L	T	T	P	L	Y	G	L	T	F	G	L	S	I	L	S	I	A	I	G	A	V	L	Y	Q	K	R	F	I	P	E	E	I	S	I	Q	E	R	H	D	G	A	S	R	E	I	D
Secondary structure
SS confidence
Disorder				?																																											?		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	K	T	V	V	A	N	L	T	D	A	F	E	G	S	T	I	R	R	R	K	L	I	G	L	S	F	G	V	G	M	G	A	F	G	L	G	T	L	V	A	F	A	G	G	L	I	K	N	P	W	K	P	V	V	P	T	A	E	G
Secondary structure
SS confidence
Disorder															?	?	?	?																									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		K	K	A	V	L	W	T	S	G	W	T	P	R	Y	Q	G	E	T	I	Y	L	A	R	A	T	G	T	E	D	G	P	P	F	I	K	M	R	P	E	D	M	D	A	G	G	M	E	T	V	F	P	W	R	E	S	D	G	D	G	T
Secondary structure
SS confidence
Disorder		?	?	?									?	?	?	?	?	?	?	?							?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?				?	?		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	V	E	S	H	H	K	L	Q	E	I	A	M	G	I	R	N	P	V	M	L	I	R	I	K	P	S	D	L	G	R	V	V	K	R	K	G	Q	E	S	F	N	F	G	E	F	F	A	F	T	K	V	C	S	H	L	G	C	P	S
Secondary structure
SS confidence
Disorder						?	?					?																?	?	?	?										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	L	Y	E	Q	Q	S	Y	R	I	L	C	P	C	H	Q	S	Q	F	D	A	L	H	F	A	K	P	I	F	G	P	A	A	R	A	L	A	Q	L	P	I	T	I	D	T	D	G	Y	L	V	A	N	G	D	F	V	E	P	V	G
Secondary structure
SS confidence
Disorder																																																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.
Sequence		P	A	F	W	E	R	T	T	T
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 37%) Alpha helix ( 27%) Beta strand ( 13%) TM helix ( 15%) (View membrane topology prediction)

Rank Aligned region

PDB 6hwh chain B Region: 49 - 428 Aligned: 380 Modelled: 380 Confidence: 100.0% Identity: 81% PDB header:electron transport Chain: B: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur subunit; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 2fyu chain E Region: 173 - 411 Aligned: 181 Modelled: 191 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: E: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur subunit, PDBTitle: crystal structure of bovine heart mitochondrial bc1 with jg1442 inhibitor Phyre2 PDB 1nyk chain A Region: 260 - 420 Aligned: 142 Modelled: 161 Confidence: 100.0% Identity: 32% Fold: ISP domain Superfamily: ISP domain Family: Rieske iron-sulfur protein (ISP) Phyre2 PDB 2fyn chain O Region: 198 - 411 Aligned: 176 Modelled: 177 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: O: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur PDBTitle: crystal structure analysis of the double mutant rhodobacter2 sphaeroides bc1 complex Phyre2 PDB 2e76 chain D Region: 197 - 424 Aligned: 160 Modelled: 170 Confidence: 99.9% Identity: 27% PDB header:photosynthesis Chain: D: PDB Molecule:cytochrome b6-f complex iron-sulfur subunit; PDBTitle: crystal structure of the cytochrome b6f complex with tridecyl-2 stigmatellin (tds) from m.laminosus Phyre2 PDB 1jm1 chain A Region: 318 - 427 Aligned: 106 Modelled: 110 Confidence: 99.9% Identity: 26% Fold: ISP domain Superfamily: ISP domain Family: Rieske iron-sulfur protein (ISP) Phyre2 PDB 1p84 chain E Region: 193 - 410 Aligned: 160 Modelled: 161 Confidence: 99.9% Identity: 18% PDB header:oxidoreductase Chain: E: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur subunit; PDBTitle: hdbt inhibited yeast cytochrome bc1 complex Phyre2 PDB 3cx5 chain E domain 1 Region: 274 - 410 Aligned: 112 Modelled: 112 Confidence: 99.9% Identity: 21% Fold: ISP domain Superfamily: ISP domain Family: Rieske iron-sulfur protein (ISP) Phyre2 PDB 1rie chain A Region: 276 - 410 Aligned: 110 Modelled: 110 Confidence: 99.9% Identity: 20% Fold: ISP domain Superfamily: ISP domain Family: Rieske iron-sulfur protein (ISP) Phyre2 PDB 4aay chain H Region: 277 - 413 Aligned: 107 Modelled: 116 Confidence: 99.9% Identity: 24% PDB header:oxidoreductase Chain: H: PDB Molecule:arob; PDBTitle: crystal structure of the arsenite oxidase protein complex2 from rhizobium species strain nt-26 Phyre2 PDB 1g8k chain B Region: 277 - 413 Aligned: 106 Modelled: 115 Confidence: 99.8% Identity: 29% Fold: ISP domain Superfamily: ISP domain Family: Rieske iron-sulfur protein (ISP) Phyre2 PDB 2nvg chain A Region: 276 - 410 Aligned: 106 Modelled: 106 Confidence: 99.8% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur subunit; PDBTitle: soluble domain of rieske iron sulfur protein. Phyre2 PDB 6fo2 chain R Region: 192 - 410 Aligned: 142 Modelled: 162 Confidence: 99.8% Identity: 25% PDB header:membrane protein Chain: R: PDB Molecule:cytochrome b-c1 complex subunit rieske, mitochondrial; PDBTitle: cryoem structure of bovine cytochrome bc1 with no ligand bound Phyre2 PDB 1rfs chain A Region: 317 - 424 Aligned: 89 Modelled: 93 Confidence: 99.7% Identity: 30% Fold: ISP domain Superfamily: ISP domain Family: Rieske iron-sulfur protein (ISP) Phyre2 PDB 2e74 chain D domain 1 Region: 344 - 417 Aligned: 71 Modelled: 74 Confidence: 99.7% Identity: 34% Fold: ISP domain Superfamily: ISP domain Family: Rieske iron-sulfur protein (ISP) Phyre2 PDB 1q90 chain C Region: 317 - 424 Aligned: 89 Modelled: 97 Confidence: 99.6% Identity: 33% Fold: ISP domain Superfamily: ISP domain Family: Rieske iron-sulfur protein (ISP) Phyre2 PDB 2qpz chain A Region: 277 - 413 Aligned: 95 Modelled: 96 Confidence: 99.5% Identity: 23% PDB header:metal binding protein Chain: A: PDB Molecule:naphthalene 1,2-dioxygenase system ferredoxin PDBTitle: naphthalene 1,2-dioxygenase rieske ferredoxin Phyre2 PDB 1fqt chain A Region: 277 - 414 Aligned: 96 Modelled: 97 Confidence: 99.4% Identity: 26% Fold: ISP domain Superfamily: ISP domain Family: Rieske iron-sulfur protein (ISP) Phyre2 PDB 2i7f chain B Region: 277 - 410 Aligned: 93 Modelled: 102 Confidence: 99.4% Identity: 23% PDB header:oxidoreductase Chain: B: PDB Molecule:ferredoxin component of dioxygenase; PDBTitle: sphingomonas yanoikuyae b1 ferredoxin Phyre2 PDB 3gce chain A Region: 318 - 411 Aligned: 75 Modelled: 76 Confidence: 99.4% Identity: 31% PDB header:oxidoreductase Chain: A: PDB Molecule:ferredoxin component of carbazole 1,9a- PDBTitle: ferredoxin of carbazole 1,9a-dioxygenase from nocardioides2 aromaticivorans ic177 Phyre2 1 c6hwhB_ 2 c2fyuE_ 3 d1nyka_ 4 c2fynO_ 5 c2e76D_ 6 d1jm1a_ 7 c1p84E_ 8 d3cx5e1 9 d1riea_ 10 c4aayH_ 11 d1g8kb_ 12 c2nvgA_ 13 c6fo2R_ 14 d1rfsa_ 15 d2e74d1 16 d1q90c_ 17 c2qpzA_ 18 d1fqta_ 19 c2i7fB_ 20 c3gceA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99