1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	P	R	G	P	G	R	L	Q	R	L	S	Q	C	R	P	Q	R	G	S	G	G	P	A	R	G	L	R	Q	L	A	L	A	A	M	L	G	A	L	A	V	T	V	S	G	C	S	W	S	E	A	L	G	I	G	W	P	E	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																														?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	T	P	E	A	H	L	N	R	E	L	W	I	G	A	V	I	A	S	L	A	V	G	V	I	V	W	G	L	I	F	W	S	A	V	F	H	R	K	K	N	T	D	T	E	L	P	R	Q	F	G	Y	N	M	P	L	E	L	V	L
Secondary structure
SS confidence
Disorder																																									?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	V	I	P	F	L	I	I	S	V	L	F	Y	F	T	V	V	V	Q	E	K	M	L	Q	I	A	K	D	P	E	V	V	I	D	I	T	S	F	Q	W	N	W	K	F	G	Y	Q	R	V	N	F	K	D	G	T	L	T	Y	D	G
Secondary structure
SS confidence
Disorder																								?		?																						?	?	?	?	?	?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	D	P	E	R	K	R	A	M	V	S	K	P	E	G	K	D	K	Y	G	E	E	L	V	G	P	V	R	G	L	N	T	E	D	R	T	Y	L	N	F	D	K	V	E	T	L	G	T	S	T	E	I	P	V	L	V	L	P	S	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?	?			?	?	?	?	?	?	?	?	?		?	?	?																				?	?	?							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		K	R	I	E	F	Q	M	A	S	A	D	V	I	H	A	F	W	V	P	E	F	L	F	K	R	D	V	M	P	N	P	V	A	N	N	S	V	N	V	F	Q	I	E	E	I	T	K	T	G	A	F	V	G	H	C	A	E	M	C	G
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	Y	H	S	M	M	N	F	E	V	R	V	V	T	P	N	D	F	K	A	Y	L	Q	Q	R	I	D	G	K	T	N	A	E	A	L	R	A	I	N	Q	P	P	L	A	V	T	T	H	P	F	D	T	R	R	G	E	L	A	P	Q
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?	?						?													?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.
Sequence		P	V	G
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 27%) Alpha helix ( 32%) Beta strand ( 21%) TM helix ( 17%) (View membrane topology prediction)

Rank Aligned region

PDB 6hwh chain L Region: 50 - 355 Aligned: 281 Modelled: 281 Confidence: 100.0% Identity: 78% PDB header:electron transport Chain: L: PDB Molecule:cytochrome c oxidase subunit 2; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 1m57 chain H Region: 48 - 331 Aligned: 255 Modelled: 264 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: H: PDB Molecule:cytochrome c oxidase; PDBTitle: structure of cytochrome c oxidase from rhodobacter2 sphaeroides (eq(i-286) mutant)) Phyre2 PDB 1ar1 chain B Region: 48 - 330 Aligned: 241 Modelled: 249 Confidence: 100.0% Identity: 25% PDB header:complex (oxidoreductase/antibody) Chain: B: PDB Molecule:cytochrome c oxidase; PDBTitle: structure at 2.7 angstrom resolution of the paracoccus2 denitrificans two-subunit cytochrome c oxidase complexed3 with an antibody fv fragment Phyre2 PDB 1qle chain B Region: 48 - 330 Aligned: 241 Modelled: 249 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase/immune system Chain: B: PDB Molecule:cytochrome c oxidase polypeptide ii; PDBTitle: cryo-structure of the paracoccus denitrificans four-subunit cytochrome2 c oxidase in the completely oxidized state complexed with an antibody3 fv fragment Phyre2 PDB 6hu9 chain N Region: 48 - 325 Aligned: 236 Modelled: 246 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase/electron transport Chain: N: PDB Molecule:cytochrome b; PDBTitle: iii2-iv2 mitochondrial respiratory supercomplex from s. cerevisiae Phyre2 PDB 1fft chain G Region: 54 - 340 Aligned: 221 Modelled: 229 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: G: PDB Molecule:ubiquinol oxidase; PDBTitle: the structure of ubiquinol oxidase from escherichia coli Phyre2 PDB 1v55 chain B Region: 50 - 325 Aligned: 225 Modelled: 232 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: B: PDB Molecule:cytochrome c oxidase polypeptide ii; PDBTitle: bovine heart cytochrome c oxidase at the fully reduced state Phyre2 PDB 2yev chain B Region: 54 - 363 Aligned: 243 Modelled: 252 Confidence: 100.0% Identity: 28% PDB header:electron transport Chain: B: PDB Molecule:cytochrome c oxidase subunit 2; PDBTitle: structure of caa3-type cytochrome oxidase Phyre2 PDB 3ehb chain B domain 1 Region: 147 - 330 Aligned: 144 Modelled: 150 Confidence: 100.0% Identity: 28% Fold: Cupredoxin-like Superfamily: Cupredoxins Family: Periplasmic domain of cytochrome c oxidase subunit II Phyre2 PDB 3dtu chain B domain 1 Region: 147 - 324 Aligned: 152 Modelled: 158 Confidence: 100.0% Identity: 27% Fold: Cupredoxin-like Superfamily: Cupredoxins Family: Periplasmic domain of cytochrome c oxidase subunit II Phyre2 PDB 4txv chain B Region: 142 - 330 Aligned: 141 Modelled: 147 Confidence: 100.0% Identity: 27% PDB header:protein binding Chain: B: PDB Molecule:cytochrome c oxidase subunit 2; PDBTitle: crystal structure of the mixed disulfide intermediate between2 thioredoxin-like tlpas(c110s) and subunit ii of cytochrome c oxidase3 coxbpd (c233s) Phyre2 PDB 1v54 chain B domain 1 Region: 147 - 325 Aligned: 136 Modelled: 142 Confidence: 100.0% Identity: 26% Fold: Cupredoxin-like Superfamily: Cupredoxins Family: Periplasmic domain of cytochrome c oxidase subunit II Phyre2 PDB 1cyx chain A Region: 150 - 338 Aligned: 125 Modelled: 131 Confidence: 100.0% Identity: 23% Fold: Cupredoxin-like Superfamily: Cupredoxins Family: Periplasmic domain of cytochrome c oxidase subunit II Phyre2 PDB 1cyx chain A Region: 150 - 338 Aligned: 125 Modelled: 131 Confidence: 100.0% Identity: 23% PDB header:electron transport Chain: A: PDB Molecule:cyoa; PDBTitle: quinol oxidase (periplasmic fragment of subunit ii with2 engineered cu-a binding site)(cyoa) Phyre2 PDB 1fft chain B domain 1 Region: 146 - 357 Aligned: 148 Modelled: 154 Confidence: 100.0% Identity: 19% Fold: Cupredoxin-like Superfamily: Cupredoxins Family: Periplasmic domain of cytochrome c oxidase subunit II Phyre2 PDB 1xme chain B Region: 105 - 314 Aligned: 164 Modelled: 178 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: B: PDB Molecule:cytochrome c oxidase polypeptide ii; PDBTitle: structure of recombinant cytochrome ba3 oxidase from thermus2 thermophilus Phyre2 PDB 2cua chain B Region: 148 - 314 Aligned: 93 Modelled: 99 Confidence: 99.9% Identity: 28% Fold: Cupredoxin-like Superfamily: Cupredoxins Family: Periplasmic domain of cytochrome c oxidase subunit II Phyre2 PDB 2cua chain A Region: 148 - 314 Aligned: 93 Modelled: 99 Confidence: 99.9% Identity: 28% Fold: Cupredoxin-like Superfamily: Cupredoxins Family: Periplasmic domain of cytochrome c oxidase subunit II Phyre2 PDB 1fft chain B domain 2 Region: 54 - 144 Aligned: 89 Modelled: 91 Confidence: 99.8% Identity: 21% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 3ehb chain B domain 2 Region: 44 - 146 Aligned: 101 Modelled: 103 Confidence: 99.8% Identity: 20% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 1 c6hwhL_ 2 c1m57H_ 3 c1ar1B_ 4 c1qleB_ 5 c6hu9n_ 6 c1fftG_ 7 c1v55B_ 8 c2yevB_ 9 d3ehbb1 10 d3dtub1 11 c4txvB_ 12 d1v54b1 13 d1cyxa_ 14 c1cyxA_ 15 d1fftb1 16 c1xmeB_ 17 d2cuab_ 18 d2cuaa_ 19 d1fftb2 20 d3ehbb2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152