1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	G	F	A	P	V	S	T	P	D	A	A	A	E	A	A	A	R	A	R	Q	D	S	L	T	K	P	R	G	A	L	G	S	L	E	D	L	S	V	W	V	A	S	C	Q	Q	R	C	P	P	R	Q	F	E	R	A	R	V	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?																		?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	F	A	G	D	H	G	V	A	R	S	G	V	S	A	Y	P	P	E	V	T	A	Q	M	V	A	N	I	D	A	G	G	A	A	I	N	A	L	A	D	V	A	G	A	T	V	R	V	A	D	L	A	V	D	A	D	P	L	S	E
Secondary structure
SS confidence
Disorder															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	I	G	A	H	K	V	R	R	G	S	G	N	I	A	T	E	D	A	L	T	N	D	E	T	A	A	A	I	T	A	G	Q	Q	I	A	D	E	E	V	D	A	G	A	D	L	L	I	A	G	D	M	G	I	G	N	T	T	A	A
Secondary structure
SS confidence
Disorder					?										?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	V	L	V	A	A	L	T	D	A	E	P	V	A	V	V	G	F	G	T	G	I	D	D	A	G	W	A	R	K	T	A	A	V	R	D	A	L	F	R	V	R	P	V	L	P	D	P	V	G	L	L	R	C	A	G	G	A	D	L
Secondary structure
SS confidence
Disorder																		?	?					?																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	A	I	A	G	F	C	A	Q	A	A	V	R	R	T	P	L	L	L	D	G	V	A	V	T	A	A	A	L	V	A	E	R	L	A	P	G	A	H	R	W	W	Q	A	G	H	R	S	S	E	P	G	H	G	L	A	L	A	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	L	D	P	I	V	D	L	H	M	R	L	G	E	G	T	G	A	A	V	A	L	M	V	L	R	A	A	V	A	A	L	S	S	M	A	T	F	T	E	A	G	V	S	T	R	S	V	D	G	V	D	R	T	A	P	P	A	V	S
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.
Sequence		P
Secondary structure
SS confidence
Disorder		?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 49%) Beta strand ( 7%)

Rank Aligned region

PDB 1l5o chain A Region: 4 - 345 Aligned: 341 Modelled: 342 Confidence: 100.0% Identity: 34% Fold: Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) Superfamily: Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) Family: Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) Phyre2 PDB 1j33 chain A Region: 12 - 345 Aligned: 331 Modelled: 334 Confidence: 100.0% Identity: 50% Fold: Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) Superfamily: Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) Family: Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) Phyre2 PDB 6b5f chain B Region: 4 - 337 Aligned: 327 Modelled: 334 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: B: PDB Molecule:nicotinate-nucleotide--dimethylbenzimidazole PDBTitle: crystal structure of nicotinate mononucleotide-5,6-2 dimethylbenzimidazole phosphoribosyltransferase cobt from yersinia3 enterocolitica Phyre2 PDB 4hdn chain A Region: 4 - 334 Aligned: 327 Modelled: 331 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:arsa; PDBTitle: crystal structure of arsab in the substrate-free state. Phyre2 PDB 4hdn chain B Region: 4 - 344 Aligned: 321 Modelled: 341 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: B: PDB Molecule:arsb; PDBTitle: crystal structure of arsab in the substrate-free state. Phyre2 PDB 3l0z chain C Region: 41 - 326 Aligned: 264 Modelled: 278 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: C: PDB Molecule:putative nicotinate-nucleotide-dimethylbenzimidazole PDBTitle: crystal structure of a putative nicotinate-nucleotide-2 dimethylbenzimidazole phosphoribosyltransferase from3 methanocaldococcus jannaschii dsm 2661 Phyre2 PDB 3u4g chain A Region: 75 - 353 Aligned: 236 Modelled: 257 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:namn:dmb phosphoribosyltransferase; PDBTitle: the structure of cobt from pyrococcus horikoshii Phyre2 PDB 4fwv chain A Region: 145 - 196 Aligned: 45 Modelled: 52 Confidence: 87.4% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:ttc1975 peptidase; PDBTitle: crystal structure of the n-terminal domain of the lon-like protease2 mtalonc Phyre2 PDB 1htw chain A Region: 146 - 187 Aligned: 42 Modelled: 42 Confidence: 63.4% Identity: 19% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: YjeE-like Phyre2 PDB 6fpe chain E Region: 145 - 198 Aligned: 52 Modelled: 54 Confidence: 48.2% Identity: 17% PDB header:rna binding protein Chain: E: PDB Molecule:atpase yjee, predicted to have essential role in cell wall PDBTitle: bacterial protein complex Phyre2 PDB 6qel chain L Region: 140 - 188 Aligned: 49 Modelled: 49 Confidence: 46.3% Identity: 20% PDB header:replication Chain: L: PDB Molecule:dna replication protein dnac; PDBTitle: e. coli dnabc apo complex Phyre2 PDB 5c3c chain B Region: 153 - 187 Aligned: 35 Modelled: 35 Confidence: 46.0% Identity: 14% PDB header:protein binding Chain: B: PDB Molecule:cbbq/nirq/norq domain protein; PDBTitle: structural characterization of a newly identified component of alpha-2 carboxysomes: the aaa+ domain protein cso-cbbq Phyre2 PDB 2zkt chain B Region: 32 - 67 Aligned: 32 Modelled: 36 Confidence: 43.4% Identity: 16% PDB header:isomerase Chain: B: PDB Molecule:2,3-bisphosphoglycerate-independent phosphoglycerate PDBTitle: structure of ph0037 protein from pyrococcus horikoshii Phyre2 PDB 5mvr chain A Region: 146 - 187 Aligned: 41 Modelled: 42 Confidence: 41.6% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:trna threonylcarbamoyladenosine biosynthesis protein tsae; PDBTitle: crystal structure of bacillus subtilus ydib Phyre2 PDB 2c99 chain A Region: 147 - 211 Aligned: 65 Modelled: 65 Confidence: 38.5% Identity: 11% PDB header:transcription regulation Chain: A: PDB Molecule:psp operon transcriptional activator; PDBTitle: structural basis of the nucleotide driven conformational2 changes in the aaa domain of transcription activator pspf Phyre2 PDB 4ww4 chain A Region: 142 - 187 Aligned: 46 Modelled: 46 Confidence: 35.9% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:ruvb-like 1; PDBTitle: double-heterohexameric rings of full-length rvb1(adp)/rvb2(adp) Phyre2 PDB 4gvg chain B Region: 1 - 150 Aligned: 134 Modelled: 150 Confidence: 35.5% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:beta-hexosaminidase; PDBTitle: crystal structure of salmonella typhimurium family 3 glycoside2 hydrolase (nagz) Phyre2 PDB 2re2 chain A Region: 151 - 175 Aligned: 25 Modelled: 25 Confidence: 35.0% Identity: 24% PDB header:oxidoreductase Chain: A: PDB Molecule:uncharacterized protein ta1041; PDBTitle: crystal structure of a putative iron-molybdenum cofactor (femo-co)2 dinitrogenase (ta1041m) from thermoplasma acidophilum dsm 1728 at3 1.30 a resolution Phyre2 PDB 1g41 chain A Region: 140 - 187 Aligned: 48 Modelled: 48 Confidence: 34.8% Identity: 27% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Extended AAA-ATPase domain Phyre2 PDB 5bq5 chain A Region: 133 - 188 Aligned: 50 Modelled: 52 Confidence: 33.6% Identity: 18% PDB header:atp-binding protein Chain: A: PDB Molecule:insertion sequence is5376 putative atp-binding protein; PDBTitle: crystal structure of the istb aaa+ domain bound to adp-bef3 Phyre2 1 d1l5oa_ 2 d1j33a_ 3 c6b5fB_ 4 c4hdnA_ 5 c4hdnB_ 6 c3l0zC_ 7 c3u4gA_ 8 c4fwvA_ 9 d1htwa_ 10 c6fpeE_ 11 c6qelL_ 12 c5c3cB_ 13 c2zktB_ 14 c5mvrA_ 15 c2c99A_ 16 c4ww4A_ 17 c4gvgB_ 18 c2re2A_ 19 d1g41a_ 20 c5bq5A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99