1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	M	R	S	L	A	T	A	F	A	F	A	T	V	I	P	T	P	G	S	A	T	T	P	M	G	R	G	P	M	T	A	L	P	V	V	G	A	A	L	G	A	L	A	A	A	I	A	W	A	G	A	Q	V	F	G	P	S	S	P
Secondary structure
SS confidence
Disorder		?	?																																																				?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	S	G	M	L	T	V	A	V	L	L	V	V	T	R	G	L	H	I	D	G	V	A	D	T	A	D	G	L	G	C	Y	G	P	P	Q	R	A	L	A	V	M	R	D	G	S	T	G	P	F	G	V	A	A	V	V	L	V	I	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	Q	G	L	A	F	A	T	L	T	T	V	G	I	A	G	I	T	L	A	V	L	S	G	R	V	T	A	V	L	V	C	R	R	L	V	P	A	A	H	G	S	T	L	G	S	R	V	A	G	T	Q	P	A	P	V	V	A	A	W
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	A	V	L	L	A	V	S	V	P	A	G	P	R	P	W	Q	G	P	I	A	V	L	V	A	V	T	A	G	A	A	L	A	A	H	C	V	H	R	F	G	G	V	T	G	D	V	L	G	S	A	I	E	L	S	T	T	V	S	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.
Sequence		V	T	L	A	G	L	A	R	L
Secondary structure
SS confidence
Disorder									?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 82%) Beta strand ( 0%) TM helix ( 61%) (View membrane topology prediction)

Rank Aligned region

PDB 1m0f chain B Region: 213 - 226 Aligned: 14 Modelled: 14 Confidence: 31.9% Identity: 50% PDB header:virus Chain: B: PDB Molecule:scaffolding protein b; PDBTitle: structural studies of bacteriophage alpha3 assembly, cryo-electron2 microscopy Phyre2 PDB 2v1s chain D Region: 72 - 105 Aligned: 34 Modelled: 34 Confidence: 24.0% Identity: 24% PDB header:oxidoreductase Chain: D: PDB Molecule:mitochondrial import receptor subunit tom20 homolog; PDBTitle: crystal structure of rat tom20-aldh presequence complex Phyre2 PDB 1om2 chain A Region: 72 - 105 Aligned: 34 Modelled: 34 Confidence: 16.8% Identity: 24% Fold: Open three-helical up-and-down bundle Superfamily: Mitochondrial import receptor subunit Tom20 Family: Mitochondrial import receptor subunit Tom20 Phyre2 PDB 1pvg chain A domain 1 Region: 75 - 84 Aligned: 10 Modelled: 10 Confidence: 16.1% Identity: 30% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: DNA gyrase/MutL, second domain Phyre2 PDB 2d6f chain C domain 1 Region: 94 - 104 Aligned: 11 Modelled: 11 Confidence: 13.1% Identity: 36% Fold: GatB/YqeY motif Superfamily: GatB/YqeY motif Family: GatB/GatE C-terminal domain-like Phyre2 PDB 5z7c chain A Region: 81 - 110 Aligned: 30 Modelled: 30 Confidence: 11.1% Identity: 30% PDB header:metal binding protein Chain: A: PDB Molecule:3'3'-cgamp-specific phosphodiesterase 3; PDBTitle: crystal structure of cyclic gmp-amp specifc phosphodiesterases in2 v.cholerae (v-cgap3) Phyre2 PDB 1otf chain A Region: 89 - 104 Aligned: 16 Modelled: 16 Confidence: 10.3% Identity: 6% Fold: Tautomerase/MIF Superfamily: Tautomerase/MIF Family: 4-oxalocrotonate tautomerase-like Phyre2 PDB 1kij chain A domain 1 Region: 75 - 84 Aligned: 10 Modelled: 10 Confidence: 9.9% Identity: 20% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: DNA gyrase/MutL, second domain Phyre2 PDB 1s16 chain A domain 1 Region: 75 - 84 Aligned: 10 Modelled: 10 Confidence: 9.6% Identity: 30% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: DNA gyrase/MutL, second domain Phyre2 PDB 1ei1 chain A domain 1 Region: 75 - 84 Aligned: 10 Modelled: 10 Confidence: 9.5% Identity: 30% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: DNA gyrase/MutL, second domain Phyre2 PDB 5k8z chain B Region: 94 - 111 Aligned: 18 Modelled: 18 Confidence: 9.3% Identity: 6% PDB header:oxidoreductase Chain: B: PDB Molecule:chlorite dismutase; PDBTitle: crystal structure of dimeric chlorite dismutase from cyanothece sp.2 pcc7425 (ph 8.5) Phyre2 PDB 6bd4 chain A Region: 17 - 135 Aligned: 117 Modelled: 119 Confidence: 8.3% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:frizzled-4/rubredoxin chimeric protein; PDBTitle: crystal structure of human apo-frizzled4 receptor Phyre2 PDB 1ckq chain A Region: 90 - 104 Aligned: 15 Modelled: 15 Confidence: 8.3% Identity: 20% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Restriction endonuclease EcoRI Phyre2 PDB 4r8z chain B Region: 81 - 104 Aligned: 24 Modelled: 24 Confidence: 7.5% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:cyclic di-gmp phosphodiesterase; PDBTitle: crystal structure of pa4781 hd-gyp domain from pseudomonas aeruginosa2 at 2.2a resolution showing a bi-metallic ni ion center Phyre2 PDB 5d92 chain B Region: 33 - 219 Aligned: 167 Modelled: 183 Confidence: 7.4% Identity: 17% PDB header:membrane protein Chain: B: PDB Molecule:af2299 protein,phosphatidylinositol synthase; PDBTitle: structure of a phosphatidylinositolphosphate (pip) synthase from2 renibacterium salmoninarum Phyre2 PDB 4faz chain B Region: 89 - 104 Aligned: 16 Modelled: 16 Confidence: 7.3% Identity: 19% PDB header:isomerase Chain: B: PDB Molecule:4-oxalocrotonate isomerase protein; PDBTitle: kinetic and structural characterization of the 4-oxalocrotonate2 tautomerase isozymes from methylibium petroleiphilum Phyre2 PDB 1bjp chain A Region: 89 - 104 Aligned: 16 Modelled: 16 Confidence: 6.9% Identity: 6% Fold: Tautomerase/MIF Superfamily: Tautomerase/MIF Family: 4-oxalocrotonate tautomerase-like Phyre2 PDB 3ry0 chain A Region: 89 - 104 Aligned: 16 Modelled: 16 Confidence: 6.5% Identity: 25% PDB header:isomerase Chain: A: PDB Molecule:putative tautomerase; PDBTitle: crystal structure of tomn, a 4-oxalocrotonate tautomerase homologue in2 tomaymycin biosynthetic pathway Phyre2 PDB 4o6m chain A Region: 33 - 215 Aligned: 165 Modelled: 183 Confidence: 6.0% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:af2299, a cdp-alcohol phosphotransferase; PDBTitle: structure of af2299, a cdp-alcohol phosphotransferase (cmp-bound) Phyre2 PDB 4ef4 chain B Region: 82 - 103 Aligned: 22 Modelled: 22 Confidence: 5.9% Identity: 5% PDB header:immune system Chain: B: PDB Molecule:transmembrane protein 173; PDBTitle: crystal structure of sting ctd complex with c-di-gmp Phyre2 1 c1m0fB_ 2 c2v1sD_ 3 d1om2a_ 4 d1pvga1 5 d2d6fc1 6 c5z7cA_ 7 d1otfa_ 8 d1kija1 9 d1s16a1 10 d1ei1a1 11 c5k8zB_ 12 c6bd4A_ 13 d1ckqa_ 14 c4r8zB_ 15 c5d92B_ 16 c4fazB_ 17 d1bjpa_ 18 c3ry0A_ 19 c4o6mA_ 20 c4ef4B_ 21 22 23 24