1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	T	E	P	G	Y	L	S	P	S	V	A	V	A	T	S	M	P	K	R	G	V	G	A	A	V	L	I	V	P	V	V	S	T	G	E	E	D	R	P	G	A	V	V	A	S	A	E	P	F	L	R	A	D	T	V	A	E	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?			?					?	?	?	?	?	?	?	?														?	?	?	?	?	?	?	?			?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	A	G	L	R	A	L	D	A	T	G	A	S	D	Q	V	H	R	L	A	V	P	S	L	P	V	G	S	V	L	T	V	G	L	G	K	P	R	R	E	W	P	A	D	T	I	R	C	A	A	G	V	A	A	R	A	L	N	S	S
Secondary structure
SS confidence
Disorder							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	A	V	I	T	T	L	A	E	L	P	G	D	G	I	C	S	A	T	V	E	G	L	I	L	G	S	Y	R	F	S	A	F	R	S	D	K	T	A	P	K	D	A	G	L	R	K	I	T	V	L	C	C	A	K	D	A	K	K	R
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	L	H	G	A	A	V	A	T	A	V	A	T	A	R	D	L	V	N	T	P	P	S	H	L	F	P	A	E	F	A	K	R	A	K	T	L	S	E	S	V	G	L	D	V	E	V	I	D	E	K	A	L	K	K	A	G	Y	G	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	I	G	V	G	Q	G	S	S	R	P	P	R	L	V	R	L	I	H	R	G	S	R	L	A	K	N	P	Q	K	A	K	K	V	A	L	V	G	K	G	I	T	F	D	T	G	G	I	S	I	K	P	A	A	S	M	H	H	M	T
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	D	M	G	G	A	A	A	V	I	A	T	V	T	L	A	A	R	L	R	L	P	I	D	V	I	A	T	V	P	M	A	E	N	M	P	S	A	T	A	Q	R	P	G	D	V	L	T	Q	Y	G	G	T	T	V	E	V	L	N	T
Secondary structure
SS confidence
Disorder																																								?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		D	A	E	G	R	L	I	L	A	D	A	I	V	R	A	C	E	D	K	P	D	Y	L	I	E	T	S	T	L	T	G	A	Q	T	V	A	L	G	T	R	I	P	G	V	M	G	S	D	E	F	R	D	R	V	A	A	I	S	Q	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		V	G	E	N	G	W	P	M	P	L	P	D	D	L	K	D	D	L	K	S	T	V	A	D	L	A	N	V	S	G	Q	R	F	A	G	M	L	V	A	G	V	F	L	R	E	F	V	A	E	S	V	D	W	A	H	I	D	V	A	G
Secondary structure
SS confidence
Disorder																															?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.
Sequence		P	A	Y	N	T	G	S	A	W	G	Y	T	P	K	G	A	T	G	V	P	T	R	T	M	F	A	V	L	E	D	I	A	K	N	G
Secondary structure
SS confidence
Disorder									?	?																								?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 35%) Beta strand ( 23%)

Rank Aligned region

PDB 3h8g chain C Region: 11 - 514 Aligned: 484 Modelled: 504 Confidence: 100.0% Identity: 38% PDB header:hydrolase Chain: C: PDB Molecule:cytosol aminopeptidase; PDBTitle: bestatin complex structure of leucine aminopeptidase from pseudomonas2 putida Phyre2 PDB 4ksi chain A Region: 1 - 510 Aligned: 493 Modelled: 510 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:leucine aminopeptidase 1, chloroplastic; PDBTitle: crystal structure analysis of the acidic leucine aminopeptidase of2 tomato Phyre2 PDB 6ome chain A Region: 10 - 514 Aligned: 486 Modelled: 505 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:probable cytosol aminopeptidase; PDBTitle: crystal structure of a probable cytosol aminopeptidase (leucine2 aminopeptidase, lap) from chlamydia trachomatis d/uw-3/cx Phyre2 PDB 1gyt chain G Region: 11 - 515 Aligned: 485 Modelled: 498 Confidence: 100.0% Identity: 34% PDB header:hydrolase Chain: G: PDB Molecule:cytosol aminopeptidase; PDBTitle: e. coli aminopeptidase a (pepa) Phyre2 PDB 3kzw chain D Region: 11 - 510 Aligned: 478 Modelled: 500 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: D: PDB Molecule:cytosol aminopeptidase; PDBTitle: crystal structure of cytosol aminopeptidase from staphylococcus aureus2 col Phyre2 PDB 3jru chain B Region: 8 - 513 Aligned: 483 Modelled: 505 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: B: PDB Molecule:probable cytosol aminopeptidase; PDBTitle: crystal structure of leucyl aminopeptidase (pepa) from xoo0834,2 xanthomonas oryzae pv. oryzae kacc10331 Phyre2 PDB 1lan chain A Region: 25 - 513 Aligned: 472 Modelled: 486 Confidence: 100.0% Identity: 32% PDB header:hydrolase (alpha-aminoacylpeptide) Chain: A: PDB Molecule:leucine aminopeptidase; PDBTitle: leucine aminopeptidase complex with l-leucinal Phyre2 PDB 4zi6 chain D Region: 11 - 515 Aligned: 470 Modelled: 485 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: D: PDB Molecule:cytosol aminopeptidase; PDBTitle: crystal structure of leucine aminopeptidase from helicobacter pylori Phyre2 PDB 5lhk chain A Region: 51 - 513 Aligned: 441 Modelled: 463 Confidence: 100.0% Identity: 40% PDB header:hydrolase Chain: A: PDB Molecule:leucine aminopeptidase 2, chloroplastic; PDBTitle: bottromycin maturation enzyme botp in complex with mn Phyre2 PDB 3kr5 chain E Region: 11 - 510 Aligned: 477 Modelled: 500 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: E: PDB Molecule:m17 leucyl aminopeptidase; PDBTitle: structure of a protease 4 Phyre2 PDB 3ij3 chain A Region: 43 - 513 Aligned: 440 Modelled: 456 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:cytosol aminopeptidase; PDBTitle: 1.8 angstrom resolution crystal structure of cytosol aminopeptidase2 from coxiella burnetii Phyre2 PDB 3pei chain A Region: 53 - 514 Aligned: 426 Modelled: 445 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:cytosol aminopeptidase; PDBTitle: crystal structure of cytosol aminopeptidase from francisella2 tularensis Phyre2 PDB 5ntg chain A Region: 24 - 511 Aligned: 463 Modelled: 487 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase; PDBTitle: structure of leucyl aminopeptidase from trypanosoma cruzi in complex2 with citrate Phyre2 PDB 2hc9 chain A Region: 10 - 511 Aligned: 473 Modelled: 494 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:leucine aminopeptidase 1; PDBTitle: structure of caenorhabditis elegans leucine aminopeptidase-zinc2 complex (lap1) Phyre2 PDB 4efd chain F Region: 38 - 511 Aligned: 457 Modelled: 469 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: F: PDB Molecule:aminopeptidase; PDBTitle: crystal structure of an m17 aminopeptidase from trypanosoma brucei,2 tb427tmp.02.4440 Phyre2 PDB 5nth chain A Region: 33 - 510 Aligned: 466 Modelled: 478 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:putative aminopeptidase; PDBTitle: structure of leucyl aminopeptidase from leishmania major in complex2 with actinonin Phyre2 PDB 1lam chain A domain 1 Region: 187 - 513 Aligned: 321 Modelled: 327 Confidence: 100.0% Identity: 39% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Leucine aminopeptidase, C-terminal domain Phyre2 PDB 1gyt chain A domain 2 Region: 186 - 514 Aligned: 318 Modelled: 329 Confidence: 100.0% Identity: 42% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Leucine aminopeptidase, C-terminal domain Phyre2 PDB 6cxd chain A Region: 89 - 514 Aligned: 402 Modelled: 426 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:peptidase b; PDBTitle: crystal structure of peptidase b from yersinia pestis co92 at 2.75 a2 resolution Phyre2 PDB 1gyt chain A domain 1 Region: 11 - 188 Aligned: 168 Modelled: 178 Confidence: 99.9% Identity: 18% Fold: Macro domain-like Superfamily: Macro domain-like Family: Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Phyre2 1 c3h8gC_ 2 c4ksiA_ 3 c6omeA_ 4 c1gytG_ 5 c3kzwD_ 6 c3jruB_ 7 c1lanA_ 8 c4zi6D_ 9 c5lhkA_ 10 c3kr5E_ 11 c3ij3A_ 12 c3peiA_ 13 c5ntgA_ 14 c2hc9A_ 15 c4efdF_ 16 c5nthA_ 17 d1lama1 18 d1gyta2 19 c6cxdA_ 20 d1gyta1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163