1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	C	T	A	C	P	T	I	W	T	L	R	C	Q	T	T	C	S	N	A	F	T	G	E	A	L	P	H	R	H	P	R	L	A	A	D	A	V	N	E	T	R	A	I	V	Q	D	V	R	N	S	I	L	L	S	A	A	S	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?											?	?	?	?	?	?	?	?		?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		W	E	I	A	I	N	Y	R	L	G	K	L	P	P	P	E	P	S	A	S	Y	V	P	D	R	M	R	R	C	G	T	S	P	L	S	V	D	H	A	H	T	A	H	R	R	A	S	G	S	P	S	T	S	I	R	P	C	A	H	R
Secondary structure
SS confidence
Disorder													?	?	?															?																?		?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.
Sequence		P	G	T	A	A	W	P	D	D	H	H	R	R	R	P	V	S	C	L
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 31%) Alpha helix ( 50%) Beta strand ( 12%)

Rank Aligned region

PDB 4xgr chain G Region: 40 - 101 Aligned: 58 Modelled: 62 Confidence: 69.5% Identity: 19% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc30; PDBTitle: crystal structure of addiction module from mycobacterial species Phyre2 PDB 2h1c chain A domain 1 Region: 40 - 101 Aligned: 62 Modelled: 62 Confidence: 43.6% Identity: 11% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1r0k chain A domain 3 Region: 79 - 102 Aligned: 24 Modelled: 24 Confidence: 32.0% Identity: 38% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: Dihydrodipicolinate reductase-like Phyre2 PDB 1q0q chain A domain 3 Region: 79 - 102 Aligned: 24 Modelled: 24 Confidence: 27.8% Identity: 25% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: Dihydrodipicolinate reductase-like Phyre2 PDB 1y82 chain A domain 1 Region: 50 - 103 Aligned: 47 Modelled: 54 Confidence: 26.6% Identity: 9% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 6a7v chain G Region: 35 - 71 Aligned: 37 Modelled: 37 Confidence: 22.5% Identity: 19% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 3dbo chain B Region: 52 - 101 Aligned: 48 Modelled: 50 Confidence: 22.2% Identity: 10% PDB header:toxin/antitoxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a member of the vapbc family of toxin-antitoxin2 systems, vapbc-5, from mycobacterium tuberculosis Phyre2 PDB 5l6m chain C Region: 41 - 104 Aligned: 63 Modelled: 64 Confidence: 22.1% Identity: 17% PDB header:hydrolase Chain: C: PDB Molecule:ribonuclease vapc; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 3a14 chain B Region: 79 - 102 Aligned: 24 Modelled: 24 Confidence: 19.2% Identity: 29% PDB header:oxidoreductase Chain: B: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: crystal structure of dxr from thermotoga maritima, in complex with2 nadph Phyre2 PDB 1r0l chain D Region: 79 - 102 Aligned: 24 Modelled: 24 Confidence: 17.5% Identity: 38% PDB header:oxidoreductase Chain: D: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: 1-deoxy-d-xylulose 5-phosphate reductoisomerase from zymomonas mobilis2 in complex with nadph Phyre2 PDB 5kqo chain A Region: 79 - 102 Aligned: 24 Modelled: 24 Confidence: 14.8% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: 1-deoxy-d-xylulose 5-phosphate reductoisomerase from vibrio vulnificus Phyre2 PDB 1k5h chain B Region: 79 - 102 Aligned: 24 Modelled: 24 Confidence: 14.8% Identity: 25% PDB header:oxidoreductase Chain: B: PDB Molecule:1-deoxy-d-xylulose-5-phosphate reductoisomerase; PDBTitle: 1-deoxy-d-xylulose-5-phosphate reductoisomerase Phyre2 PDB 4zn6 chain B Region: 79 - 102 Aligned: 24 Modelled: 24 Confidence: 14.0% Identity: 25% PDB header:oxidoreductase Chain: B: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: x-ray crystal structure of 1-deoxy-d-xylulose 5-phosphate2 reductoisomerase (ispc) from acinetobacter baumannii Phyre2 PDB 2egh chain A Region: 79 - 102 Aligned: 24 Modelled: 24 Confidence: 13.5% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase2 complexed with a magnesium ion, nadph and fosmidomycin Phyre2 PDB 3tnd chain C Region: 42 - 99 Aligned: 56 Modelled: 58 Confidence: 13.0% Identity: 18% PDB header:translation, toxin Chain: C: PDB Molecule:trna(fmet)-specific endonuclease vapc; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 2i5o chain A Region: 56 - 63 Aligned: 8 Modelled: 8 Confidence: 10.8% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:dna polymerase eta; PDBTitle: solution structure of the ubiquitin-binding zinc finger2 (ubz) domain of the human dna y-polymerase eta Phyre2 PDB 5fmt chain B Region: 56 - 91 Aligned: 35 Modelled: 36 Confidence: 9.8% Identity: 26% PDB header:protein transport Chain: B: PDB Molecule:flagellar associated protein; PDBTitle: crift54 ch-domain Phyre2 PDB 3fia chain A Region: 58 - 93 Aligned: 36 Modelled: 36 Confidence: 9.2% Identity: 19% PDB header:protein binding Chain: A: PDB Molecule:intersectin-1; PDBTitle: crystal structure of the eh 1 domain from human intersectin-1 protein.2 northeast structural genomics consortium target hr3646e. Phyre2 PDB 4cu2 chain A Region: 5 - 10 Aligned: 6 Modelled: 6 Confidence: 8.3% Identity: 83% PDB header:hydrolase Chain: A: PDB Molecule:endolysin; PDBTitle: c-terminal domain of ctp1l endolysin mutant v195p that reduces2 autoproteolysis Phyre2 PDB 2gyc chain M domain 1 Region: 45 - 97 Aligned: 52 Modelled: 53 Confidence: 8.1% Identity: 25% Fold: Ribonuclease H-like motif Superfamily: Translational machinery components Family: Ribosomal protein L18 and S11 Phyre2 1 c4xgrG_ 2 d2h1ca1 3 d1r0ka3 4 d1q0qa3 5 d1y82a1 6 c6a7vG_ 7 c3dboB_ 8 c5l6mC_ 9 c3a14B_ 10 c1r0lD_ 11 c5kqoA_ 12 c1k5hB_ 13 c4zn6B_ 14 c2eghA_ 15 c3tndC_ 16 c2i5oA_ 17 c5fmtB_ 18 c3fiaA_ 19 c4cu2A_ 20 d2gycm1 21 22 23 24 25 26 27 28 29 30 31