1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	R	L	A	F	L	L	R	P	G	W	L	A	L	A	L	V	V	V	A	F	T	Y	L	C	F	T	V	L	A	P	W	Q	L	G	K	N	A	K	T	S	R	E	N	Q	Q	I	R	Y	S	L	D	T	P	P	V	P	L	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																													?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	L	L	P	Q	Q	D	S	S	A	P	D	A	Q	W	R	R	V	T	A	T	G	Q	Y	L	P	D	V	Q	V	L	A	R	L	R	V	V	E	G	D	Q	A	F	E	V	L	A	P	F	V	V	D	G	G	P	T	V	L	V	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	G	Y	V	R	P	Q	V	G	S	H	V	P	P	I	P	R	L	P	V	Q	T	V	T	I	T	A	R	L	R	D	S	E	P	S	V	A	G	K	D	P	F	V	R	D	G	F	Q	Q	V	Y	S	I	N	T	G	Q	V	A	A
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?	?	?	?	?	?												?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	T	G	V	Q	L	A	G	S	Y	L	Q	L	I	E	D	Q	P	G	G	L	G	V	L	G	V	P	H	L	D	P	G	P	F	L	S	Y	G	I	Q	W	I	S	F	G	I	L	A	P	I	G	L	G	Y	F	A	Y	A	E	I
Secondary structure
SS confidence
Disorder																			?	?			?		?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.
Sequence		R	A	R	R	R	E	K	A	G	S	P	P	P	D	K	P	M	T	V	E	Q	K	L	A	D	R	Y	G	R	R	R
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 35%) Alpha helix ( 34%) Beta strand ( 20%) TM helix ( 14%) (View membrane topology prediction)

Rank Aligned region

PDB 2mc7 chain A Region: 14 - 35 Aligned: 21 Modelled: 22 Confidence: 50.8% Identity: 33% PDB header:membrane protein Chain: A: PDB Molecule:regulatory peptide; PDBTitle: structure of salmonella mgtr Phyre2 PDB 1zza chain A Region: 15 - 39 Aligned: 25 Modelled: 25 Confidence: 33.4% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:stannin; PDBTitle: solution nmr structure of the membrane protein stannin Phyre2 PDB 5n9y chain B Region: 212 - 240 Aligned: 29 Modelled: 29 Confidence: 29.2% Identity: 14% PDB header:membrane protein Chain: B: PDB Molecule:zinc transport protein zntb; PDBTitle: the full-length structure of zntb Phyre2 PDB 2lx0 chain A Region: 14 - 41 Aligned: 28 Modelled: 28 Confidence: 28.6% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:membrane fusion protein p14; PDBTitle: arced helix (arch) nmr structure of the reovirus p14 fusion-associated2 small transmembrane (fast) protein transmembrane domain (tmd) in3 dodecyl phosphocholine (dpc) micelles Phyre2 PDB 3tqz chain A Region: 87 - 122 Aligned: 36 Modelled: 36 Confidence: 28.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)2 from coxiella burnetii Phyre2 PDB 6gcs chain W Region: 191 - 267 Aligned: 77 Modelled: 77 Confidence: 26.3% Identity: 12% PDB header:oxidoreductase Chain: W: PDB Molecule:nb6m subunit; PDBTitle: cryo-em structure of respiratory complex i from yarrowia lipolytica Phyre2 PDB 1six chain A Region: 87 - 123 Aligned: 37 Modelled: 37 Confidence: 26.1% Identity: 22% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 2i5n chain H Region: 219 - 243 Aligned: 25 Modelled: 25 Confidence: 25.0% Identity: 12% PDB header:photosynthesis Chain: H: PDB Molecule:reaction center protein h chain; PDBTitle: 1.96 a x-ray structure of photosynthetic reaction center from2 rhodopseudomonas viridis:crystals grown by microfluidic technique Phyre2 PDB 2bbj chain B Region: 214 - 238 Aligned: 25 Modelled: 25 Confidence: 23.4% Identity: 24% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 3ca9 chain A Region: 87 - 122 Aligned: 36 Modelled: 36 Confidence: 20.2% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase Phyre2 PDB 2r6i chain A domain 1 Region: 42 - 108 Aligned: 66 Modelled: 67 Confidence: 18.3% Identity: 15% Fold: ATP12-like Superfamily: ATP12-like Family: ATP12-like Phyre2 PDB 5lnk chain Q Region: 191 - 267 Aligned: 77 Modelled: 77 Confidence: 18.2% Identity: 17% PDB header:oxidoreductase Chain: Q: PDB Molecule: PDBTitle: entire ovine respiratory complex i Phyre2 PDB 5o31 chain Z Region: 191 - 267 Aligned: 77 Modelled: 77 Confidence: 16.7% Identity: 17% PDB header:oxidoreductase Chain: Z: PDB Molecule:nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit PDBTitle: mitochondrial complex i in the deactive state Phyre2 PDB 6rdr chain 8 Region: 221 - 248 Aligned: 28 Modelled: 28 Confidence: 16.4% Identity: 21% PDB header:proton transport Chain: 8: PDB Molecule:mitochondrial atp synthase subunit asa8; PDBTitle: cryo-em structure of polytomella f-atp synthase, rotary substate 1d,2 monomer-masked refinement Phyre2 PDB 6rdi chain 8 Region: 221 - 248 Aligned: 28 Modelled: 28 Confidence: 16.4% Identity: 21% PDB header:proton transport Chain: 8: PDB Molecule:mitochondrial atp synthase subunit asa8; PDBTitle: cryo-em structure of polytomella f-atp synthase, rotary substate 1a,2 monomer-masked refinement Phyre2 PDB 1thq chain A Region: 57 - 88 Aligned: 27 Modelled: 32 Confidence: 15.4% Identity: 33% Fold: Transmembrane beta-barrels Superfamily: OMPA-like Family: Outer membrane enzyme PagP Phyre2 PDB 6mai chain A Region: 87 - 122 Aligned: 36 Modelled: 36 Confidence: 15.3% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5'-triphosphate nucleotidohydrolase2 from legionella pneumophila philadelphia 1 Phyre2 PDB 6mpl chain A Region: 18 - 37 Aligned: 20 Modelled: 20 Confidence: 14.4% Identity: 35% PDB header:membrane protein Chain: A: PDB Molecule:matrix protein 2; PDBTitle: racemic m2-tm i39a crystallized from racemic detergent Phyre2 PDB 2na6 chain A Region: 222 - 244 Aligned: 23 Modelled: 23 Confidence: 14.2% Identity: 26% PDB header:apoptosis Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of mouse fas/cd95 death receptor Phyre2 PDB 2na6 chain B Region: 222 - 244 Aligned: 23 Modelled: 23 Confidence: 14.2% Identity: 26% PDB header:apoptosis Chain: B: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of mouse fas/cd95 death receptor Phyre2 1 c2mc7A_ 2 c1zzaA_ 3 c5n9yB_ 4 c2lx0A_ 5 c3tqzA_ 6 c6gcsW_ 7 d1sixa_ 8 c2i5nH_ 9 c2bbjB_ 10 c3ca9A_ 11 d2r6ia1 12 c5lnkq_ 13 c5o31Z_ 14 c6rdr8_ 15 c6rdi8_ 16 d1thqa_ 17 c6maiA_ 18 c6mplA_ 19 c2na6A_ 20 c2na6B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80