1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	F	A	S	T	W	Q	T	R	A	V	G	V	L	I	G	C	L	L	D	V	V	F	G	D	P	K	R	G	H	P	V	A	L	F	G	R	A	A	A	K	L	E	Q	I	T	Y	R	D	G	R	V	A	G	A	V	H	V	G	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	V	G	A	V	G	L	L	G	A	A	L	Q	R	L	P	G	R	S	W	P	V	A	A	T	A	T	A	T	W	A	A	L	G	G	T	S	L	A	R	T	G	R	Q	I	S	D	L	L	E	R	D	D	V	E	A	A	R	R	L
Secondary structure
SS confidence
Disorder																																																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	P	S	L	C	G	R	D	P	A	Q	L	G	G	P	G	L	T	R	A	A	L	E	S	V	A	E	N	T	A	D	A	Q	V	V	P	L	L	W	A	A	S	S	G	V	P	A	V	L	G	Y	R	A	I	N	T	L	D	S	M
Secondary structure
SS confidence
Disorder													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	G	Y	R	S	P	R	Y	L	R	F	G	W	A	A	A	R	L	D	D	W	A	N	Y	V	G	A	R	A	T	A	V	L	V	V	I	C	A	P	V	V	G	G	S	P	R	G	A	V	R	A	W	R	R	D	A	A	R	H	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	P	N	A	G	V	V	E	A	A	F	A	G	A	L	D	V	R	L	G	G	P	T	R	Y	H	H	E	L	Q	I	R	P	T	L	G	D	G	R	S	P	K	V	A	D	L	R	R	A	V	V	L	S	R	V	V	Q	A	G	A
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.
Sequence		A	V	L	A	V	M	L	V	Y	R	R	R	P
Secondary structure
SS confidence
Disorder												?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 4%) Alpha helix ( 73%) Beta strand ( 2%) TM helix ( 43%) (View membrane topology prediction)

Rank Aligned region

PDB 5h93 chain C Region: 239 - 252 Aligned: 14 Modelled: 14 Confidence: 77.7% Identity: 43% PDB header:hydrolase Chain: C: PDB Molecule:geobacter metallireducens smug1; PDBTitle: crystal structure of geobacter metallireducens smug1 Phyre2 PDB 6iiu chain A Region: 94 - 126 Aligned: 33 Modelled: 33 Confidence: 43.1% Identity: 18% PDB header:signaling protein Chain: A: PDB Molecule:soluble cytochrome b562,thromboxane a2 receptor,rubredoxin, PDBTitle: crystal structure of the human thromboxane a2 receptor bound to2 ramatroban Phyre2 PDB 4l6r chain A Region: 94 - 170 Aligned: 77 Modelled: 77 Confidence: 32.2% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:soluble cytochrome b562 and glucagon receptor chimera; PDBTitle: structure of the class b human glucagon g protein coupled receptor Phyre2 PDB 256b chain A Region: 94 - 124 Aligned: 31 Modelled: 31 Confidence: 28.5% Identity: 19% Fold: Four-helical up-and-down bundle Superfamily: Cytochromes Family: Cytochrome b562 Phyre2 PDB 4er9 chain A Region: 94 - 124 Aligned: 31 Modelled: 31 Confidence: 28.1% Identity: 19% PDB header:electron transport Chain: A: PDB Molecule:soluble cytochrome b562; PDBTitle: crystal structure of cytochrome b562 from salmonella enterica subsp.2 enterica serovar typhimurium str. 14028s Phyre2 PDB 6g7o chain A Region: 94 - 125 Aligned: 32 Modelled: 32 Confidence: 23.9% Identity: 19% PDB header:membrane protein Chain: A: PDB Molecule:alkaline ceramidase 3,soluble cytochrome b562; PDBTitle: crystal structure of human alkaline ceramidase 3 (acer3) at 2.72 angstrom resolution Phyre2 PDB 1sxj chain C domain 1 Region: 100 - 145 Aligned: 44 Modelled: 46 Confidence: 12.7% Identity: 16% Fold: post-AAA+ oligomerization domain-like Superfamily: post-AAA+ oligomerization domain-like Family: DNA polymerase III clamp loader subunits, C-terminal domain Phyre2 PDB 1sr2 chain A Region: 92 - 124 Aligned: 33 Modelled: 33 Confidence: 12.6% Identity: 12% Fold: Four-helical up-and-down bundle Superfamily: Histidine-containing phosphotransfer domain, HPT domain Family: Sensor-like histidine kinase YojN, C-terminal domain Phyre2 PDB 3nrt chain C Region: 128 - 154 Aligned: 27 Modelled: 27 Confidence: 12.2% Identity: 22% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:putative ryanodine receptor; PDBTitle: the crystal strucutre of putative ryanodine receptor from bacteroides2 thetaiotaomicron vpi-5482 Phyre2 PDB 1iqp chain A domain 1 Region: 100 - 145 Aligned: 44 Modelled: 46 Confidence: 10.4% Identity: 18% Fold: post-AAA+ oligomerization domain-like Superfamily: post-AAA+ oligomerization domain-like Family: DNA polymerase III clamp loader subunits, C-terminal domain Phyre2 PDB 3u8p chain B Region: 94 - 125 Aligned: 32 Modelled: 32 Confidence: 8.6% Identity: 19% PDB header:fluorescent protein, electron transport Chain: B: PDB Molecule:cytochrome b562 integral fusion with enhanced green PDBTitle: cytochrome b562 integral fusion with egfp Phyre2 PDB 4etv chain A Region: 128 - 154 Aligned: 27 Modelled: 27 Confidence: 8.3% Identity: 22% PDB header:metal transport Chain: A: PDB Molecule:ryanodine receptor 2; PDBTitle: crystal structure of mouse ryanodine receptor 2 (2699-2904) Phyre2 PDB 1t6z chain B Region: 101 - 121 Aligned: 21 Modelled: 21 Confidence: 7.8% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:riboflavin kinase/fmn adenylyltransferase; PDBTitle: crystal structure of riboflavin bound tm379 Phyre2 PDB 3j3v chain N Region: 96 - 152 Aligned: 57 Modelled: 57 Confidence: 7.4% Identity: 12% PDB header:ribosome Chain: N: PDB Molecule:50s ribosomal protein l17; PDBTitle: atomic model of the immature 50s subunit from bacillus subtilis (state2 i-a) Phyre2 PDB 1hw1 chain A domain 2 Region: 96 - 123 Aligned: 28 Modelled: 28 Confidence: 7.1% Identity: 7% Fold: GntR ligand-binding domain-like Superfamily: GntR ligand-binding domain-like Family: GntR ligand-binding domain-like Phyre2 PDB 4g78 chain A Region: 92 - 124 Aligned: 33 Modelled: 33 Confidence: 7.1% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:histidine phosphotransfer protein; PDBTitle: subatomic resolution crystal structure of histidine-containing2 phosphotransfer protein mthpt2 from medicago truncatula Phyre2 PDB 1khd chain A domain 2 Region: 82 - 127 Aligned: 43 Modelled: 46 Confidence: 7.0% Identity: 19% Fold: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Phyre2 PDB 3op1 chain A Region: 101 - 121 Aligned: 21 Modelled: 21 Confidence: 6.7% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:macrolide-efflux protein; PDBTitle: crystal structure of macrolide-efflux protein sp_1110 from2 streptococcus pneumoniae Phyre2 PDB 3ixz chain B Region: 152 - 187 Aligned: 36 Modelled: 36 Confidence: 6.7% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:potassium-transporting atpase subunit beta; PDBTitle: pig gastric h+/k+-atpase complexed with aluminium fluoride Phyre2 PDB 1wn0 chain A domain 1 Region: 92 - 124 Aligned: 33 Modelled: 33 Confidence: 6.5% Identity: 15% Fold: Four-helical up-and-down bundle Superfamily: Histidine-containing phosphotransfer domain, HPT domain Family: Phosphorelay protein-like Phyre2 1 c5h93C_ 2 c6iiuA_ 3 c4l6rA_ 4 d256ba_ 5 c4er9A_ 6 c6g7oA_ 7 d1sxjc1 8 d1sr2a_ 9 c3nrtC_ 10 d1iqpa1 11 c3u8pB_ 12 c4etvA_ 13 c1t6zB_ 14 c3j3vN_ 15 d1hw1a2 16 c4g78A_ 17 d1khda2 18 c3op1A_ 19 c3ixzB_ 20 d1wn0a1 21 22 23 24 25 26