1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	L	I	G	W	R	A	V	P	R	R	H	G	G	E	L	P	R	R	G	A	L	A	L	G	C	I	A	L	L	L	M	G	I	V	G	C	T	T	V	T	D	G	T	A	M	P	D	T	N	V	A	P	A	Y	R	S	S	V	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																					?	?		?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	S	V	S	A	S	A	A	T	S	S	I	R	E	S	Q	R	Q	Q	S	L	T	T	K	A	I	R	T	S	C	D	A	L	A	A	T	S	K	D	A	I	D	K	V	N	A	Y	V	A	A	F	N	Q	G	R	N	T	G	P	T
Secondary structure
SS confidence
Disorder								?	?	?	?																									?	?	?	?															?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	G	P	A	I	D	A	L	N	N	S	A	S	T	V	S	G	S	L	S	A	A	L	S	A	Q	L	G	D	A	L	N	A	Y	V	D	A	A	R	A	V	A	N	A	I	G	A	H	A	S	T	A	E	F	N	R	R	V	D	R
Secondary structure
SS confidence
Disorder		?	?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.
Sequence		L	N	D	T	K	T	K	A	L	T	M	C	V	A	A	F
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 36%) Alpha helix ( 77%) Beta strand ( 0%) TM helix ( 8%) (View membrane topology prediction)

Rank Aligned region

PDB 2ke3 chain A Region: 104 - 130 Aligned: 27 Modelled: 27 Confidence: 44.3% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:neuroendocrine convertase 1; PDBTitle: pc1/3 dcsg sorting domain in chaps Phyre2 PDB 2kdt chain A Region: 104 - 130 Aligned: 27 Modelled: 27 Confidence: 41.4% Identity: 19% PDB header:protein transport Chain: A: PDB Molecule:neuroendocrine convertase 1; PDBTitle: pc1/3 dcsg sorting domain structure in dpc Phyre2 PDB 3k3w chain A Region: 101 - 121 Aligned: 21 Modelled: 21 Confidence: 25.3% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:penicillin g acylase; PDBTitle: thermostable penicillin g acylase from alcaligenes faecalis in2 orthorhombic form Phyre2 PDB 5h5m chain A Region: 82 - 193 Aligned: 104 Modelled: 112 Confidence: 25.0% Identity: 10% PDB header:cell adhesion Chain: A: PDB Molecule:alpha-catenin-like protein hmp-1; PDBTitle: crystal structure of hmp-1 m domain Phyre2 PDB 1wii chain A Region: 98 - 118 Aligned: 21 Modelled: 21 Confidence: 21.1% Identity: 19% Fold: Rubredoxin-like Superfamily: Zinc beta-ribbon Family: Putative zinc binding domain Phyre2 PDB 5fhy chain A Region: 91 - 119 Aligned: 29 Modelled: 29 Confidence: 19.4% Identity: 10% PDB header:structural protein Chain: A: PDB Molecule:b-type flagellar hook-associated protein 2; PDBTitle: crystal structure of flid (hap2) from pseudomonas aeruginosa pao1 Phyre2 PDB 4c9y chain B Region: 165 - 184 Aligned: 20 Modelled: 19 Confidence: 17.7% Identity: 10% PDB header:cell cycle Chain: B: PDB Molecule:spindle and kinetochore-associated protein 1; PDBTitle: structural basis for the microtubule binding of the human2 kinetochore ska complex Phyre2 PDB 2lyc chain A Region: 165 - 184 Aligned: 20 Modelled: 20 Confidence: 17.6% Identity: 15% PDB header:protein binding Chain: A: PDB Molecule:spindle and kinetochore-associated protein 1 homolog; PDBTitle: structure of c-terminal domain of ska1 Phyre2 PDB 2lfc chain A Region: 84 - 115 Aligned: 32 Modelled: 32 Confidence: 16.4% Identity: 6% PDB header:oxidoreductase Chain: A: PDB Molecule:fumarate reductase, flavoprotein subunit; PDBTitle: solution nmr structure of fumarate reductase flavoprotein subunit from2 lactobacillus plantarum, northeast structural genomics consortium3 target lpr145j Phyre2 PDB 2zxe chain G Region: 18 - 38 Aligned: 21 Modelled: 21 Confidence: 15.5% Identity: 14% PDB header:hydrolase/transport protein Chain: G: PDB Molecule:phospholemman-like protein; PDBTitle: crystal structure of the sodium - potassium pump in the e2.2k+.pi2 state Phyre2 PDB 5xog chain M Region: 99 - 110 Aligned: 12 Modelled: 12 Confidence: 15.4% Identity: 25% PDB header:transcription Chain: M: PDB Molecule:transcription elongation factor 1 homolog; PDBTitle: rna polymerase ii elongation complex bound with spt5 kow5 and elf1 Phyre2 PDB 6d6r chain L Region: 165 - 181 Aligned: 17 Modelled: 17 Confidence: 14.6% Identity: 29% PDB header:hydrolase Chain: L: PDB Molecule:m-phase phosphoprotein 6; PDBTitle: human nuclear exosome-mtr4 rna complex - composite map after focused2 reconstruction Phyre2 PDB 6d6q chain L Region: 165 - 181 Aligned: 17 Modelled: 17 Confidence: 14.6% Identity: 29% PDB header:hydrolase Chain: L: PDB Molecule:m-phase phosphoprotein 6; PDBTitle: human nuclear exosome-mtr4 rna complex - overall reconstruction Phyre2 PDB 2mmp chain A Region: 139 - 154 Aligned: 16 Modelled: 16 Confidence: 13.3% Identity: 19% PDB header:ribosomal protein Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of a ribosomal protein Phyre2 PDB 1st6 chain A domain 5 Region: 112 - 195 Aligned: 84 Modelled: 84 Confidence: 13.0% Identity: 26% Fold: Four-helical up-and-down bundle Superfamily: alpha-catenin/vinculin-like Family: alpha-catenin/vinculin Phyre2 PDB 2kt5 chain B Region: 9 - 19 Aligned: 11 Modelled: 11 Confidence: 12.9% Identity: 55% PDB header:rna binding protein / viral protein Chain: B: PDB Molecule:icp27; PDBTitle: rrm domain of mrna export adaptor ref2-i bound to hsv-1 icp27 peptide Phyre2 PDB 2asx chain A domain 1 Region: 147 - 191 Aligned: 45 Modelled: 45 Confidence: 10.4% Identity: 9% Fold: HAMP domain-like Superfamily: HAMP domain-like Family: HAMP domain Phyre2 PDB 1d4c chain A domain 3 Region: 84 - 115 Aligned: 32 Modelled: 32 Confidence: 9.1% Identity: 16% Fold: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Superfamily: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Family: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Phyre2 PDB 5fim chain A Region: 169 - 194 Aligned: 26 Modelled: 26 Confidence: 8.2% Identity: 8% PDB header:unknown function Chain: A: PDB Molecule:ygau; PDBTitle: the structure of kbp.k from e. coli Phyre2 PDB 2iho chain A domain 2 Region: 90 - 106 Aligned: 17 Modelled: 17 Confidence: 7.9% Identity: 41% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: MOA C-terminal domain-like Phyre2 1 c2ke3A_ 2 c2kdtA_ 3 c3k3wA_ 4 c5h5mA_ 5 d1wiia_ 6 c5fhyA_ 7 c4c9yB_ 8 c2lycA_ 9 c2lfcA_ 10 c2zxeG_ 11 c5xogM_ 12 c6d6rL_ 13 c6d6qL_ 14 c2mmpA_ 15 d1st6a5 16 c2kt5B_ 17 d2asxa1 18 d1d4ca3 19 c5fimA_ 20 d2ihoa2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39