1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	R	Q	Q	L	D	V	Q	V	K	N	G	G	L	V	R	V	W	Y	G	V	Y	A	A	Q	E	P	D	L	L	G	R	L	A	A	L	D	V	F	M	G	G	H	A	V	A	C	L	G	T	A	A	A	L	Y	G	F	D	T
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	N	T	V	A	I	H	M	L	D	P	G	V	R	M	R	P	T	V	G	L	M	V	H	Q	R	V	G	A	R	L	Q	R	V	S	G	R	L	A	T	A	P	A	W	T	A	V	E	V	A	R	Q	L	R	R	P	R	A	L	A
Secondary structure
SS confidence
Disorder												?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	L	D	A	A	L	R	S	M	R	C	A	R	S	E	I	E	N	A	V	A	E	Q	R	G	R	R	G	I	V	A	A	R	E	L	L	P	F	A	D	G	R	A	E	S	A	M	E	S	E	A	R	L	V	M	I	D	H	G	L
Secondary structure
SS confidence
Disorder																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	L	P	E	L	Q	Y	P	I	H	G	H	G	G	E	M	W	R	V	D	F	A	W	P	D	M	R	L	A	A	E	Y	E	S	I	E	W	H	A	G	P	A	E	M	L	R	D	K	T	R	W	A	K	L	Q	E	L	G	W	T
Secondary structure
SS confidence
Disorder																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.
Sequence		I	V	P	I	V	V	D	D	V	R	R	E	P	G	R	L	A	A	R	I	A	R	H	L	D	R	A	R	M	A	G
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 6%) Alpha helix ( 44%) Beta strand ( 20%)

Rank Aligned region

PDB 3r3p chain B Region: 164 - 264 Aligned: 93 Modelled: 101 Confidence: 99.7% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:mobile intron protein; PDBTitle: homing endonuclease i-bth0305i catalytic domain Phyre2 PDB 3hrl chain A Region: 163 - 268 Aligned: 91 Modelled: 106 Confidence: 99.5% Identity: 24% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:endonuclease-like protein; PDBTitle: crystal structure of a putative endonuclease-like protein (ngo0050)2 from neisseria gonorrhoeae Phyre2 PDB 1cw0 chain A Region: 162 - 266 Aligned: 99 Modelled: 105 Confidence: 99.4% Identity: 22% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 1vsr chain A Region: 167 - 265 Aligned: 93 Modelled: 99 Confidence: 97.9% Identity: 22% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 4par chain C Region: 182 - 271 Aligned: 89 Modelled: 90 Confidence: 97.4% Identity: 13% PDB header:dna binding protein/dna Chain: C: PDB Molecule:uncharacterized protein abasi; PDBTitle: the 5-hydroxymethylcytosine-specific restriction enzyme abasi in a2 complex with product-like dna Phyre2 PDB 4oq2 chain A Region: 169 - 271 Aligned: 102 Modelled: 103 Confidence: 97.4% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:restriction endonuclease pvurts1 i; PDBTitle: 5hmc specific restriction endonuclease pvurts1i Phyre2 PDB 6rdu chain 2 Region: 199 - 249 Aligned: 51 Modelled: 51 Confidence: 95.2% Identity: 6% PDB header:proton transport Chain: 2: PDB Molecule:asa-2: polytomella f-atp synthase associated subunit 2; PDBTitle: cryo-em structure of polytomella f-atp synthase, rotary substate 1e,2 monomer-masked refinement Phyre2 PDB 1zel chain A Region: 3 - 162 Aligned: 155 Modelled: 160 Confidence: 87.8% Identity: 21% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein rv2827c; PDBTitle: crystal structure of rv2827c protein from mycobacterium tuberculosis Phyre2 PDB 1zel chain A domain 2 Region: 43 - 162 Aligned: 115 Modelled: 120 Confidence: 73.8% Identity: 22% Fold: Rv2827c C-terminal domain-like Superfamily: Rv2827c C-terminal domain-like Family: Rv2827c C-terminal domain-like Phyre2 PDB 1m0d chain A Region: 165 - 236 Aligned: 64 Modelled: 72 Confidence: 55.5% Identity: 16% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Endonuclease I (Holliday junction resolvase) Phyre2 PDB 6mp2 chain B Region: 205 - 271 Aligned: 64 Modelled: 67 Confidence: 35.4% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:blman5b; PDBTitle: crystal structure of blman5b solved by siras Phyre2 PDB 6gvb chain C Region: 207 - 271 Aligned: 62 Modelled: 65 Confidence: 33.6% Identity: 15% PDB header:hydrolase Chain: C: PDB Molecule:exo-beta-1,4-mannosidase; PDBTitle: crystal structure of cutibacterium acnes exo-beta-1,4-mannosidase Phyre2 PDB 3tts chain D Region: 203 - 271 Aligned: 64 Modelled: 69 Confidence: 31.9% Identity: 16% PDB header:hydrolase Chain: D: PDB Molecule:beta-galactosidase; PDBTitle: crystal structure of beta-galactosidase from bacillus circulans sp.2 alkalophilus Phyre2 PDB 2fcl chain A domain 1 Region: 44 - 64 Aligned: 21 Modelled: 21 Confidence: 26.2% Identity: 24% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: TM1012-like Phyre2 PDB 4ytk chain A Region: 10 - 23 Aligned: 14 Modelled: 14 Confidence: 21.1% Identity: 36% PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt5; PDBTitle: structure of the kow1-linker1 domain of transcription elongation2 factor spt5 Phyre2 PDB 5e9a chain B Region: 204 - 271 Aligned: 65 Modelled: 68 Confidence: 13.2% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:beta-galactosidase; PDBTitle: crystal structure analysis of the cold-adamped beta-galactosidase from2 rahnella sp. r3 Phyre2 PDB 1kwg chain A domain 2 Region: 218 - 271 Aligned: 51 Modelled: 54 Confidence: 11.4% Identity: 24% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: Amylase, catalytic domain Phyre2 PDB 3otb chain B Region: 200 - 218 Aligned: 19 Modelled: 19 Confidence: 11.0% Identity: 11% PDB header:transferase Chain: B: PDB Molecule:trna(his) guanylyltransferase; PDBTitle: crystal structure of human trnahis guanylyltransferase (thg1) - dgtp2 complex Phyre2 PDB 3wbz chain D Region: 200 - 218 Aligned: 19 Modelled: 19 Confidence: 10.8% Identity: 16% PDB header:transferase Chain: D: PDB Molecule:likely histidyl trna-specific guanylyltransferase; PDBTitle: crystal structure of c. albicans trna(his) guanylyltransferase (thg1)2 with atp Phyre2 PDB 5xox chain D Region: 200 - 218 Aligned: 19 Modelled: 19 Confidence: 10.6% Identity: 16% PDB header:transferase Chain: D: PDB Molecule:trna(his) guanylyltransferase; PDBTitle: crystal structure of trna(his) guanylyltranserase from saccharomyces2 cerevisiae Phyre2 1 c3r3pB_ 2 c3hrlA_ 3 d1cw0a_ 4 d1vsra_ 5 c4parC_ 6 c4oq2A_ 7 c6rdu2_ 8 c1zelA_ 9 d1zela2 10 d1m0da_ 11 c6mp2B_ 12 c6gvbC_ 13 c3ttsD_ 14 d2fcla1 15 c4ytkA_ 16 c5e9aB_ 17 d1kwga2 18 c3otbB_ 19 c3wbzD_ 20 c5xoxD_ 21 22 23 24 25 26 27 28 29 30