1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	R	Y	R	D	L	E	T	V	A	A	P	T	I	N	V	L	R	V	W	P	E	I	V	G	A	I	V	L	L	V	I	A	A	M	G	I	G	H	G	L	R	P	S	P	E	P	V	P	A	P	Q	K	Q	L	G	C	V	R	F
Secondary structure
SS confidence
Disorder		?	?	?	?																																				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	L	I	F	G	L	T	A	I	N	P	A	T	F	V	Y	F	T	A	V	A	V	T	L	A	R	A	L	R	A	T	T	A	I	A	V	V	V	G	V	A	L	A	S	L	L	W	Q	L	L	L	V	S	A	G	A	F	L	R	S
Secondary structure
SS confidence
Disorder																										?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.
Sequence		R	A	T	A	R	V	R	R	M	T	V	L	A	G	N	A	V	I	A	A	F	G	A	V	L	V	V	H	A	F	A
Secondary structure
SS confidence
Disorder																															?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 18%) Alpha helix ( 85%) Beta strand ( 0%) TM helix ( 52%) (View membrane topology prediction)

Rank Aligned region

PDB 5vkv chain A Region: 6 - 151 Aligned: 144 Modelled: 146 Confidence: 98.2% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c-type biogenesis protein ccda; PDBTitle: solution nmr structure of the membrane electron transporter ccda Phyre2 PDB 2n4x chain A Region: 19 - 149 Aligned: 123 Modelled: 131 Confidence: 93.0% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:cytochrome c-type biogenesis protein (ccda); PDBTitle: structure of the transmembrane electron transporter ccda Phyre2 PDB 1afo chain B Region: 83 - 121 Aligned: 39 Modelled: 39 Confidence: 16.9% Identity: 18% PDB header:integral membrane protein Chain: B: PDB Molecule:glycophorin a; PDBTitle: dimeric transmembrane domain of human glycophorin a, nmr,2 20 structures Phyre2 PDB 4kt0 chain F Region: 20 - 64 Aligned: 39 Modelled: 45 Confidence: 11.5% Identity: 18% PDB header:electron transport Chain: F: PDB Molecule:photosystem i subunit iii; PDBTitle: crystal structure of a virus like photosystem i from the2 cyanobacterium synechocystis pcc 6803 Phyre2 PDB 1jb0 chain F Region: 20 - 69 Aligned: 44 Modelled: 50 Confidence: 10.9% Identity: 18% Fold: Single transmembrane helix Superfamily: Subunit III of photosystem I reaction centre, PsaF Family: Subunit III of photosystem I reaction centre, PsaF Phyre2 PDB 6fos chain F Region: 20 - 64 Aligned: 39 Modelled: 45 Confidence: 10.6% Identity: 15% PDB header:photosynthesis Chain: F: PDB Molecule:photosystem i reaction center subunit ii; PDBTitle: cyanidioschyzon merolae photosystem i Phyre2 PDB 1j0t chain A Region: 14 - 26 Aligned: 13 Modelled: 13 Confidence: 7.8% Identity: 46% Fold: Crustacean CHH/MIH/GIH neurohormone Superfamily: Crustacean CHH/MIH/GIH neurohormone Family: Crustacean CHH/MIH/GIH neurohormone Phyre2 PDB 1j0t chain A Region: 14 - 26 Aligned: 13 Modelled: 13 Confidence: 7.8% Identity: 46% PDB header:hormone/growth factor Chain: A: PDB Molecule:molt-inhibiting hormone; PDBTitle: the solution structure of molt-inhibiting hormone from the2 kuruma prawn Phyre2 PDB 2jp3 chain A Region: 125 - 148 Aligned: 24 Modelled: 24 Confidence: 7.8% Identity: 13% PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles Phyre2 PDB 6igz chain F Region: 20 - 64 Aligned: 39 Modelled: 45 Confidence: 7.7% Identity: 15% PDB header:plant protein Chain: F: PDB Molecule:psaf; PDBTitle: structure of psi-lhci Phyre2 PDB 6cfw chain F Region: 72 - 142 Aligned: 71 Modelled: 71 Confidence: 7.2% Identity: 10% PDB header:membrane protein Chain: F: PDB Molecule:monovalent cation/h+ antiporter subunit b; PDBTitle: cryoem structure of a respiratory membrane-bound hydrogenase Phyre2 PDB 6ijj chain F Region: 20 - 69 Aligned: 44 Modelled: 50 Confidence: 7.0% Identity: 16% PDB header:membrane protein Chain: F: PDB Molecule:psaf; PDBTitle: photosystem i of chlamydomonas reinhardtii Phyre2 PDB 5n6m chain A Region: 52 - 141 Aligned: 90 Modelled: 90 Confidence: 6.9% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:apolipoprotein n-acyltransferase; PDBTitle: structure of the membrane integral lipoprotein n-acyltransferase lnt2 from p. aeruginosa Phyre2 PDB 2mkv chain A Region: 127 - 148 Aligned: 22 Modelled: 22 Confidence: 6.8% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:sodium/potassium-transporting atpase subunit gamma; PDBTitle: structure of the na,k-atpase regulatory protein fxyd2b in micelles Phyre2 PDB 5xtd chain M Region: 27 - 68 Aligned: 42 Modelled: 42 Confidence: 6.7% Identity: 12% PDB header:oxidoreductase/electron transport Chain: M: PDB Molecule:nadh-ubiquinone oxidoreductase 75 kda subunit, PDBTitle: cryo-em structure of human respiratory complex i Phyre2 PDB 2jo1 chain A Region: 125 - 148 Aligned: 24 Modelled: 24 Confidence: 6.5% Identity: 13% PDB header:hydrolase regulator Chain: A: PDB Molecule:phospholemman; PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles Phyre2 PDB 5ire chain A Region: 20 - 34 Aligned: 15 Modelled: 15 Confidence: 5.9% Identity: 13% PDB header:virus Chain: A: PDB Molecule:e protein; PDBTitle: the cryo-em structure of zika virus Phyre2 PDB 5wsn chain C Region: 20 - 34 Aligned: 15 Modelled: 15 Confidence: 5.7% Identity: 13% PDB header:virus Chain: C: PDB Molecule:e protein; PDBTitle: structure of japanese encephalitis virus Phyre2 PDB 3n23 chain E Region: 123 - 148 Aligned: 26 Modelled: 26 Confidence: 5.7% Identity: 15% PDB header:hydrolase Chain: E: PDB Molecule:na+/k+ atpase gamma subunit transcript variant a; PDBTitle: crystal structure of the high affinity complex between ouabain and the2 e2p form of the sodium-potassium pump Phyre2 PDB 1p58 chain C Region: 20 - 34 Aligned: 15 Modelled: 15 Confidence: 5.6% Identity: 13% PDB header:virus Chain: C: PDB Molecule:major envelope protein e; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 1 c5vkvA_ 2 c2n4xA_ 3 c1afoB_ 4 c4kt0F_ 5 d1jb0f_ 6 c6fosF_ 7 d1j0ta_ 8 c1j0tA_ 9 c2jp3A_ 10 c6igzF_ 11 c6cfwF_ 12 c6ijjF_ 13 c5n6mA_ 14 c2mkvA_ 15 c5xtdm_ 16 c2jo1A_ 17 c5ireA_ 18 c5wsnC_ 19 c3n23E_ 20 c1p58C_ 21 22 23 24 25