1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	G	A	N	G	D	V	A	L	S	R	I	G	A	T	R	P	A	L	S	A	W	R	F	V	T	V	F	G	V	V	G	L	L	A	D	V	V	Y	E	G	A	R	S	I	T	G	P	L	L	A	S	L	G	A	T	G	L	V	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	V	V	T	G	V	G	E	A	A	A	L	G	L	R	L	V	S	G	P	L	A	D	R	S	R	R	F	W	A	W	T	I	A	G	Y	T	L	T	V	V	T	V	P	L	L	G	I	A	G	A	L	W	V	A	C	A	L	V	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	E	R	V	G	K	A	V	R	G	P	A	K	D	T	L	L	S	H	A	A	S	V	T	G	R	G	R	G	F	A	V	H	E	A	L	D	Q	V	G	A	M	I	G	P	L	T	V	A	G	M	L	A	I	T	G	N	A	Y	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	A	L	G	V	L	T	L	P	G	G	A	A	L	A	L	L	L	W	L	Q	R	R	V	P	R	P	E	S	Y	E	D	C	P	V	V	L	G	N	P	S	A	P	R	P	W	A	L	P	A	Q	F	W	L	Y	C	G	F	T	A
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	T	M	L	G	F	G	T	F	G	L	L	S	F	H	M	V	S	H	G	V	L	A	A	A	M	V	P	V	V	Y	A	A	A	M	A	A	D	A	L	T	A	L	A	S	G	F	S	Y	D	R	Y	G	A	K	T	L	A	V	L
Secondary structure
SS confidence
Disorder																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		P	I	L	S	I	L	V	V	L	F	A	F	T	D	N	V	T	M	V	V	I	G	T	L	V	W	G	A	A	V	G	I	Q	E	S	T	L	R	G	V	V	A	D	L	V	A	S	P	R	R	A	S	A	Y	G	V	F	A	A	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.
Sequence		L	G	A	A	T	A	G	G	G	A	L	I	G	W	L	Y	D	I	S	I	G	T	L	V	V	V	V	I	A	L	E	L	M	A	L	V	M	M	F	A	I	R	L	P	R	V	A	P	S
Secondary structure
SS confidence
Disorder																																												?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 83%) Beta strand ( 0%) TM helix ( 63%) (View membrane topology prediction)

Rank Aligned region

PDB 6e9o chain A Region: 16 - 408 Aligned: 392 Modelled: 393 Confidence: 100.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 3wdo chain A Region: 14 - 405 Aligned: 388 Modelled: 392 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 4zp0 chain A Region: 15 - 404 Aligned: 388 Modelled: 390 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 1pw4 chain A Region: 2 - 405 Aligned: 402 Modelled: 404 Confidence: 100.0% Identity: 15% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 4iky chain A Region: 2 - 404 Aligned: 401 Modelled: 403 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:di-tripeptide abc transporter (permease); PDBTitle: crystal structure of peptide transporter pot (e310q mutant) in complex2 with sulfate Phyre2 PDB 4cl5 chain B Region: 13 - 408 Aligned: 395 Modelled: 396 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: B: PDB Molecule:nitrate transporter 1.1; PDBTitle: crystal structure of the nitrate transporter nrt1.1 from2 arabidopsis thaliana in complex with nitrate. Phyre2 PDB 2gfp chain A Region: 25 - 396 Aligned: 364 Modelled: 372 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 4lds chain B Region: 24 - 407 Aligned: 383 Modelled: 384 Confidence: 100.0% Identity: 15% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 6g9x chain B Region: 22 - 407 Aligned: 366 Modelled: 369 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 4aps chain B Region: 23 - 401 Aligned: 378 Modelled: 379 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: B: PDB Molecule:di-or tripeptide h+ symporter; PDBTitle: crystal structure of a pot family peptide transporter in an inward2 open conformation. Phyre2 PDB 6exs chain A Region: 8 - 404 Aligned: 395 Modelled: 397 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:peptide abc transporter permease; PDBTitle: crystal structure of a pot family transporter in complex with2 thioalcohol conjugated peptide. Phyre2 PDB 4iu8 chain A Region: 3 - 401 Aligned: 398 Modelled: 398 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter (selenomethionine2 derivative) Phyre2 PDB 1pv7 chain A Region: 21 - 408 Aligned: 387 Modelled: 388 Confidence: 100.0% Identity: 12% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: LacY-like proton/sugar symporter Phyre2 PDB 1pv7 chain B Region: 21 - 408 Aligned: 387 Modelled: 388 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:lactose permease; PDBTitle: crystal structure of lactose permease with tdg Phyre2 PDB 6gs7 chain A Region: 23 - 404 Aligned: 382 Modelled: 382 Confidence: 100.0% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:dipeptide and tripeptide permease a; PDBTitle: crystal structure of peptide transporter dtpa-nanobody in glycine2 buffer Phyre2 PDB 4j05 chain A Region: 20 - 408 Aligned: 388 Modelled: 389 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 6h7d chain A Region: 18 - 409 Aligned: 391 Modelled: 392 Confidence: 100.0% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:sugar transport protein 10; PDBTitle: crystal structure of a. thaliana sugar transport protein 10 in complex2 with glucose in the outward occluded state Phyre2 PDB 3o7p chain A Region: 23 - 406 Aligned: 381 Modelled: 384 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 4w6v chain A Region: 10 - 404 Aligned: 394 Modelled: 393 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:di-/tripeptide transporter; PDBTitle: crystal structure of a peptide transporter from yersinia2 enterocolitica at 3 a resolution Phyre2 PDB 5c65 chain A Region: 16 - 409 Aligned: 393 Modelled: 394 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: structure of the human glucose transporter glut3 / slc2a3 Phyre2 1 c6e9oA_ 2 c3wdoA_ 3 c4zp0A_ 4 d1pw4a_ 5 c4ikyA_ 6 c4cl5B_ 7 c2gfpA_ 8 c4ldsB_ 9 c6g9xB_ 10 c4apsB_ 11 c6exsA_ 12 c4iu8A_ 13 d1pv7a_ 14 c1pv7B_ 15 c6gs7A_ 16 c4j05A_ 17 c6h7dA_ 18 c3o7pA_ 19 c4w6vA_ 20 c5c65A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43