1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	N	R	H	S	T	A	A	S	D	R	G	L	Q	A	E	R	T	T	L	A	W	T	R	T	A	F	A	L	L	V	N	G	V	L	L	T	L	K	D	T	Q	G	A	D	G	P	A	G	L	I	P	A	G	L	A	G	A	A	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																										?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.
Sequence		S	C	C	Y	V	I	A	L	Q	R	Q	R	A	L	S	H	R	P	L	P	A	R	I	T	P	R	G	Q	V	H	I	L	A	T	A	V	L	V	L	M	V	V	T	A	F	A	Q	L	L
Secondary structure
SS confidence
Disorder																?	?	?	?	?	?	?	?	?			?		?																				?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 32%) Alpha helix ( 69%) Beta strand ( 0%) TM helix ( 33%) (View membrane topology prediction)

Rank Aligned region

PDB 5kk9 chain A Region: 1 - 7 Aligned: 7 Modelled: 7 Confidence: 32.1% Identity: 100% PDB header:transport protein Chain: A: PDB Molecule:gap junction beta-1 protein; PDBTitle: connexin 32 g12r n-terminal mutant, Phyre2 PDB 2y94 chain C Region: 83 - 107 Aligned: 25 Modelled: 25 Confidence: 19.9% Identity: 20% PDB header:transferase Chain: C: PDB Molecule:5'-amp-activated protein kinase catalytic subunit alpha-1; PDBTitle: structure of an active form of mammalian ampk Phyre2 PDB 2p06 chain A domain 1 Region: 55 - 69 Aligned: 15 Modelled: 15 Confidence: 10.0% Identity: 27% Fold: all-alpha NTP pyrophosphatases Superfamily: all-alpha NTP pyrophosphatases Family: AF0060-like Phyre2 PDB 2p06 chain A Region: 55 - 69 Aligned: 15 Modelled: 15 Confidence: 10.0% Identity: 27% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein af_0060; PDBTitle: crystal structure of a predicted coding region af_0060 from2 archaeoglobus fulgidus dsm 4304 Phyre2 PDB 3p7j chain A Region: 10 - 17 Aligned: 8 Modelled: 8 Confidence: 8.1% Identity: 75% PDB header:transcription Chain: A: PDB Molecule:heterochromatin protein 1; PDBTitle: drosophila hp1a chromo shadow domain Phyre2 PDB 1dz1 chain A Region: 10 - 17 Aligned: 8 Modelled: 8 Confidence: 7.5% Identity: 63% Fold: SH3-like barrel Superfamily: Chromo domain-like Family: Chromo domain Phyre2 PDB 4pzu chain F Region: 70 - 81 Aligned: 12 Modelled: 12 Confidence: 6.5% Identity: 42% PDB header:transferase Chain: F: PDB Molecule:uncharacterized protein rv3404c/mt3512; PDBTitle: crystal structure of a putative uncharacterize protein rv3404c and2 likely sugar n-formyltransferase from mycobacterium tuberculosis Phyre2 PDB 3ggz chain H Region: 69 - 75 Aligned: 7 Modelled: 7 Confidence: 6.3% Identity: 71% PDB header:protein transport, endocytosis Chain: H: PDB Molecule:vacuolar protein-sorting-associated protein 46; PDBTitle: crystal structure of s.cerevisiae ist1 n-terminal domain in complex2 with did2 mim motif Phyre2 PDB 3ggz chain E Region: 69 - 75 Aligned: 7 Modelled: 7 Confidence: 6.2% Identity: 71% PDB header:protein transport, endocytosis Chain: E: PDB Molecule:vacuolar protein-sorting-associated protein 46; PDBTitle: crystal structure of s.cerevisiae ist1 n-terminal domain in complex2 with did2 mim motif Phyre2 PDB 3ggz chain F Region: 69 - 75 Aligned: 7 Modelled: 7 Confidence: 6.2% Identity: 71% PDB header:protein transport, endocytosis Chain: F: PDB Molecule:vacuolar protein-sorting-associated protein 46; PDBTitle: crystal structure of s.cerevisiae ist1 n-terminal domain in complex2 with did2 mim motif Phyre2 PDB 6igz chain M Region: 27 - 43 Aligned: 16 Modelled: 17 Confidence: 6.1% Identity: 38% PDB header:plant protein Chain: M: PDB Molecule:photosystem i reaction center subunit xii; PDBTitle: structure of psi-lhci Phyre2 PDB 5h7p chain B Region: 69 - 75 Aligned: 7 Modelled: 7 Confidence: 6.1% Identity: 71% PDB header:protein transport Chain: B: PDB Molecule:vacuolar protein-sorting-associated protein 46; PDBTitle: nmr structure of the vta1ntd-did2(176-204) complex Phyre2 PDB 3ggz chain G Region: 69 - 75 Aligned: 7 Modelled: 7 Confidence: 6.1% Identity: 71% PDB header:protein transport, endocytosis Chain: G: PDB Molecule:vacuolar protein-sorting-associated protein 46; PDBTitle: crystal structure of s.cerevisiae ist1 n-terminal domain in complex2 with did2 mim motif Phyre2 PDB 2fmm chain A domain 1 Region: 10 - 17 Aligned: 8 Modelled: 8 Confidence: 6.0% Identity: 63% Fold: SH3-like barrel Superfamily: Chromo domain-like Family: Chromo domain Phyre2 PDB 4hr1 chain A Region: 12 - 30 Aligned: 19 Modelled: 19 Confidence: 5.9% Identity: 42% PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of pav1-137, a protein from the virus pav1 that infects2 pyrococcus abyssi. Phyre2 1 c5kk9A_ 2 c2y94C_ 3 d2p06a1 4 c2p06A_ 5 c3p7jA_ 6 d1dz1a_ 7 c4pzuF_ 8 c3ggzH_ 9 c3ggzE_ 10 c3ggzF_ 11 c6igzM_ 12 c5h7pB_ 13 c3ggzG_ 14 d2fmma1 15 c4hr1A_