1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	Y	V	A	A	E	P	G	V	L	I	S	P	T	D	D	L	Q	S	P	R	S	A	P	A	A	H	D	E	N	A	D	G	I	T	G	G	T	R	D	D	S	A	P	N	S	R	F	Q	L	G	R	R	I	P	E	A	T	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?			?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	E	G	F	L	V	R	P	F	T	Q	Q	C	Q	I	I	H	T	E	G	D	H	A	V	I	G	V	S	P	G	N	S	Y	F	S	R	Q	R	L	R	D	L	G	L	W	G	L	T	N	F	D	R	V	D	F	V	Y	T	D	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	V	A	E	S	Y	E	A	L	G	D	S	A	I	E	A	R	R	K	A	V	K	N	I	R	G	V	R	A	K	I	T	T	T	V	N	E	L	D	P	A	G	A	R	L	C	V	R	P	M	S	E	F	Q	S	N	E	A	Y	R
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?																									?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	L	H	A	D	L	L	T	R	L	K	D	D	E	D	L	R	A	V	C	Q	D	L	V	R	R	F	L	S	T	K	V	G	P	R	Q	G	A	T	A	T	Q	E	Q	V	C	M	D	Y	I	C	A	E	A	P	L	F	L	D	T
Secondary structure
SS confidence
Disorder																														?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.
Sequence		P	A	I	L	G	V	P	S	S	L	N	C	Y	H	Q	S	L	P	L	A	E	M	L	Y	A	R	G	S	G	L	R	A	S	R	N	Q	G	H	A	I	V	T	P	D	G	S	P	A	E
Secondary structure
SS confidence
Disorder			?	?																				?	?	?	?	?	?	?	?	?	?	?	?									?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 33%) Alpha helix ( 45%) Beta strand ( 11%)

Rank Aligned region

PDB 2x9q chain A Region: 49 - 284 Aligned: 231 Modelled: 236 Confidence: 100.0% Identity: 98% PDB header:ligase Chain: A: PDB Molecule:cyclodipeptide synthetase; PDBTitle: structure of the mycobacterium tuberculosis protein, rv2275,2 demonstrates that cyclodipeptide synthetases are related3 to type i trna-synthetases. Phyre2 PDB 3oqh chain B Region: 62 - 283 Aligned: 220 Modelled: 222 Confidence: 100.0% Identity: 26% PDB header:ligase Chain: B: PDB Molecule:putative uncharacterized protein yvmc; PDBTitle: crystal structure of b. licheniformis cdps yvmc-blic Phyre2 PDB 6ez3 chain C Region: 63 - 285 Aligned: 217 Modelled: 223 Confidence: 100.0% Identity: 23% PDB header:rna binding protein Chain: C: PDB Molecule:cyclo(l-leucyl-l-leucyl) synthase; PDBTitle: structure of cdps from staphylococcus haemolyticus Phyre2 PDB 3oqv chain A Region: 79 - 283 Aligned: 204 Modelled: 205 Confidence: 100.0% Identity: 35% PDB header:protein binding Chain: A: PDB Molecule:albc; PDBTitle: albc, a cyclodipeptide synthase from streptomyces noursei Phyre2 PDB 5ocd chain D Region: 83 - 238 Aligned: 153 Modelled: 156 Confidence: 98.6% Identity: 12% PDB header:rna binding protein Chain: D: PDB Molecule:cyclodipeptide synthase; PDBTitle: structure of a cdps from fluoribacter dumoffii Phyre2 PDB 5mlq chain A Region: 69 - 238 Aligned: 165 Modelled: 166 Confidence: 98.0% Identity: 20% PDB header:ligase Chain: A: PDB Molecule:cdps; PDBTitle: structure of cdps from nocardia brasiliensis Phyre2 PDB 5mlp chain A Region: 76 - 233 Aligned: 155 Modelled: 158 Confidence: 94.7% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of cdps from rickettsiella grylli Phyre2 PDB 2nw8 chain A domain 1 Region: 181 - 250 Aligned: 59 Modelled: 70 Confidence: 71.6% Identity: 22% Fold: Indolic compounds 2,3-dioxygenase-like Superfamily: Indolic compounds 2,3-dioxygenase-like Family: Bacterial tryptophan 2,3-dioxygenase Phyre2 PDB 2nox chain P Region: 181 - 250 Aligned: 59 Modelled: 70 Confidence: 70.1% Identity: 20% PDB header:oxidoreductase Chain: P: PDB Molecule:tryptophan 2,3-dioxygenase; PDBTitle: crystal structure of tryptophan 2,3-dioxygenase from ralstonia2 metallidurans Phyre2 PDB 1cuk chain A domain 1 Region: 120 - 142 Aligned: 23 Modelled: 23 Confidence: 67.0% Identity: 30% Fold: RuvA C-terminal domain-like Superfamily: DNA helicase RuvA subunit, C-terminal domain Family: DNA helicase RuvA subunit, C-terminal domain Phyre2 PDB 1ugp chain A Region: 150 - 260 Aligned: 92 Modelled: 111 Confidence: 58.8% Identity: 14% Fold: Nitrile hydratase alpha chain Superfamily: Nitrile hydratase alpha chain Family: Nitrile hydratase alpha chain Phyre2 PDB 3qyh chain G Region: 184 - 260 Aligned: 62 Modelled: 77 Confidence: 57.9% Identity: 18% PDB header:lyase Chain: G: PDB Molecule:co-type nitrile hydratase alpha subunit; PDBTitle: crystal structure of co-type nitrile hydratase beta-h71l from2 pseudomonas putida. Phyre2 PDB 3ol0 chain C Region: 31 - 51 Aligned: 21 Modelled: 21 Confidence: 51.7% Identity: 52% PDB header:de novo protein Chain: C: PDB Molecule:de novo designed monomer trefoil-fold sub-domain which PDBTitle: crystal structure of monofoil-4p homo-trimer: de novo designed monomer2 trefoil-fold sub-domain which forms homo-trimer assembly Phyre2 PDB 2gwc chain E Region: 140 - 253 Aligned: 107 Modelled: 113 Confidence: 43.5% Identity: 11% PDB header:ligase Chain: E: PDB Molecule:glutamate cysteine ligase; PDBTitle: crystal structure of plant glutamate cysteine ligase in complex with a2 transition state analogue Phyre2 PDB 4hka chain A Region: 170 - 234 Aligned: 65 Modelled: 65 Confidence: 42.4% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:tryptophan 2,3-dioxygenase; PDBTitle: crystal structure of drosophila melanogaster tryptophan 2,3-2 dioxygenase in complex with heme Phyre2 PDB 1ufz chain A Region: 170 - 233 Aligned: 55 Modelled: 64 Confidence: 31.4% Identity: 13% Fold: RuvA C-terminal domain-like Superfamily: HBS1-like domain Family: HBS1-like domain Phyre2 PDB 1wiv chain A Region: 118 - 163 Aligned: 46 Modelled: 46 Confidence: 31.0% Identity: 13% Fold: RuvA C-terminal domain-like Superfamily: UBA-like Family: UBA domain Phyre2 PDB 2cob chain A domain 1 Region: 213 - 253 Aligned: 41 Modelled: 41 Confidence: 25.9% Identity: 15% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: Psq domain Phyre2 PDB 1vek chain A Region: 118 - 156 Aligned: 36 Modelled: 39 Confidence: 25.9% Identity: 14% Fold: RuvA C-terminal domain-like Superfamily: UBA-like Family: UBA domain Phyre2 PDB 3ogf chain A Region: 31 - 51 Aligned: 21 Modelled: 21 Confidence: 25.4% Identity: 52% PDB header:de novo protein Chain: A: PDB Molecule:de novo designed dimeric trefoil-fold sub-domain which PDBTitle: crystal structure of difoil-4p homo-trimer: de novo designed dimeric2 trefoil-fold sub-domain which forms homo-trimer assembly Phyre2 1 c2x9qA_ 2 c3oqhB_ 3 c6ez3C_ 4 c3oqvA_ 5 c5ocdD_ 6 c5mlqA_ 7 c5mlpA_ 8 d2nw8a1 9 c2noxP_ 10 d1cuka1 11 d1ugpa_ 12 c3qyhG_ 13 c3ol0C_ 14 c2gwcE_ 15 c4hkaA_ 16 d1ufza_ 17 d1wiva_ 18 d2coba1 19 d1veka_ 20 c3ogfA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99