1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	D	N	A	K	H	H	R	D	G	H	L	V	A	S	G	L	Q	D	R	A	A	R	T	P	Q	H	E	G	F	L	G	P	D	R	P	W	H	L	S	F	S	L	L	L	A	G	S	F	V	L	F	S	W	W	A	F	D	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?			?	?	?		?				?		?	?																										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	G	S	G	A	N	K	V	I	L	V	L	A	T	V	V	G	M	F	M	A	F	N	V	G	G	N	D	V	A	N	S	F	G	T	S	V	G	A	G	T	L	T	M	K	Q	A	L	L	V	A	A	I	F	E	V	S	G	A	V
Secondary structure
SS confidence
Disorder																																								?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	A	G	G	D	V	T	E	T	I	R	S	G	I	V	D	L	S	G	V	S	V	D	P	R	D	F	M	N	I	M	L	S	A	L	S	A	A	A	L	W	L	L	F	A	N	R	M	G	Y	P	V	S	T	T	H	S	I	I	G
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?	?	?																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	I	V	G	A	A	I	A	L	G	M	V	S	G	Q	G	G	A	A	L	R	M	V	Q	W	D	Q	I	G	Q	I	V	V	S	W	V	L	S	P	V	L	G	G	L	V	S	Y	L	L	Y	G	V	I	K	R	H	I	L	L	Y
Secondary structure
SS confidence
Disorder															?	?	?		?	?																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	E	Q	A	E	R	R	L	T	E	I	K	K	E	R	I	A	H	R	E	R	H	K	A	A	F	D	R	L	T	E	I	Q	Q	I	A	Y	T	G	A	L	A	R	D	A	V	A	A	N	R	K	D	F	D	P	D	E	L	E	S
Secondary structure
SS confidence
Disorder			?	?																	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?		?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	Y	Y	R	E	L	H	E	I	D	A	K	T	S	S	V	D	A	F	R	A	L	Q	N	W	V	P	L	V	A	A	A	G	S	M	I	I	V	A	M	L	L	F	K	G	F	K	H	M	H	L	G	L	T	T	M	N	N	Y	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?									?			?		?	?		?	?	?	?	?		?					?	?	?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		I	I	A	M	V	G	A	A	V	W	M	A	T	F	I	F	A	K	T	L	R	G	E	S	L	S	R	S	T	F	L	M	F	S	W	M	Q	V	F	T	A	S	G	F	A	F	S	H	G	S	N	D	I	A	N	A	I	G	P	F
Secondary structure
SS confidence
Disorder																							?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	A	I	L	D	V	L	R	T	G	A	I	E	G	N	A	A	V	P	A	A	A	M	V	T	F	G	V	A	L	C	A	G	L	W	F	I	G	R	R	V	I	A	T	V	G	H	N	L	T	T	M	H	P	A	S	G	F	A	A
Secondary structure
SS confidence
Disorder									?			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		E	L	S	A	A	G	V	V	M	G	A	T	V	L	G	L	P	V	S	S	T	H	I	L	I	G	A	V	L	G	V	G	I	V	N	R	S	T	N	W	G	L	M	K	P	I	V	L	A	W	V	I	T	L	P	S	A	A	I	L
Secondary structure
SS confidence
Disorder															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.
Sequence		A	S	V	G	L	V	A	L	R	A	I	F
Secondary structure
SS confidence
Disorder												?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 82%) Beta strand ( 0%) TM helix ( 55%) (View membrane topology prediction)

Rank Aligned region

PDB 2w2e chain A Region: 61 - 243 Aligned: 181 Modelled: 183 Confidence: 73.1% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:aquaporin pip2-7 7; PDBTitle: 1.15 angstrom crystal structure of p.pastoris aquaporin, aqy1, in a2 closed conformation at ph 3.5 Phyre2 PDB 1j4n chain A Region: 59 - 233 Aligned: 173 Modelled: 175 Confidence: 64.2% Identity: 17% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 4r0c chain B Region: 6 - 179 Aligned: 167 Modelled: 174 Confidence: 61.9% Identity: 11% PDB header:membrane protein Chain: B: PDB Molecule:abgt putative transporter family; PDBTitle: crystal structure of the alcanivorax borkumensis ydah transporter2 reveals an unusual topology Phyre2 PDB 1fx8 chain A Region: 43 - 233 Aligned: 189 Modelled: 191 Confidence: 40.6% Identity: 17% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 6eu6 chain A Region: 59 - 248 Aligned: 182 Modelled: 184 Confidence: 34.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:ammonium transporter; PDBTitle: sensor amt protein Phyre2 PDB 2ia2 chain D Region: 490 - 516 Aligned: 27 Modelled: 27 Confidence: 25.1% Identity: 15% PDB header:transcription Chain: D: PDB Molecule:putative transcriptional regulator; PDBTitle: the crystal structure of a putative transcriptional regulator rha061952 from rhodococcus sp. rha1 Phyre2 PDB 1lda chain A Region: 43 - 233 Aligned: 190 Modelled: 191 Confidence: 23.4% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:glycerol uptake facilitator protein; PDBTitle: crystal structure of the e. coli glycerol facilitator (glpf) without2 substrate glycerol Phyre2 PDB 2b6p chain A Region: 44 - 233 Aligned: 183 Modelled: 190 Confidence: 20.0% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:lens fiber major intrinsic protein; PDBTitle: x-ray structure of lens aquaporin-0 (aqp0) (lens mip) in an open pore2 state Phyre2 PDB 4g1u chain B Region: 67 - 183 Aligned: 117 Modelled: 117 Confidence: 17.9% Identity: 18% PDB header:transport protein/hydrolase Chain: B: PDB Molecule:hemin transport system permease protein hmuu; PDBTitle: x-ray structure of the bacterial heme transporter hmuuv from yersinia2 pestis Phyre2 PDB 2g7u chain B Region: 490 - 516 Aligned: 27 Modelled: 27 Confidence: 17.7% Identity: 22% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:transcriptional regulator; PDBTitle: 2.3 a structure of putative catechol degradative operon regulator from2 rhodococcus sp. rha1 Phyre2 PDB 2bru chain C Region: 83 - 94 Aligned: 12 Modelled: 12 Confidence: 17.4% Identity: 33% PDB header:oxidoreductase Chain: C: PDB Molecule:nad(p) transhydrogenase subunit beta; PDBTitle: complex of the domain i and domain iii of escherichia coli2 transhydrogenase Phyre2 PDB 2nuu chain F Region: 59 - 245 Aligned: 180 Modelled: 181 Confidence: 17.3% Identity: 19% PDB header:transport protein/signaling protein Chain: F: PDB Molecule:ammonia channel; PDBTitle: regulating the escherichia coli ammonia channel: the crystal structure2 of the amtb-glnk complex Phyre2 PDB 1d4o chain A Region: 83 - 94 Aligned: 12 Modelled: 12 Confidence: 15.9% Identity: 42% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Transhydrogenase domain III (dIII) Phyre2 PDB 1pt9 chain B Region: 83 - 94 Aligned: 12 Modelled: 12 Confidence: 15.8% Identity: 42% PDB header:oxidoreductase Chain: B: PDB Molecule:nad(p) transhydrogenase, mitochondrial; PDBTitle: crystal structure analysis of the diii component of transhydrogenase2 with a thio-nicotinamide nucleotide analogue Phyre2 PDB 1pno chain A Region: 83 - 94 Aligned: 12 Modelled: 12 Confidence: 15.6% Identity: 42% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Transhydrogenase domain III (dIII) Phyre2 PDB 3r4k chain D Region: 490 - 516 Aligned: 27 Modelled: 27 Confidence: 15.2% Identity: 15% PDB header:dna binding protein Chain: D: PDB Molecule:transcriptional regulator, iclr family; PDBTitle: crystal structure of a putative iclr transcriptional regulator2 (tm1040_3717) from silicibacter sp. tm1040 at 2.46 a resolution Phyre2 PDB 1mkm chain A Region: 490 - 516 Aligned: 27 Modelled: 27 Confidence: 13.8% Identity: 22% PDB header:transcription Chain: A: PDB Molecule:iclr transcriptional regulator; PDBTitle: crystal structure of the thermotoga maritima iclr Phyre2 PDB 2f2b chain A Region: 57 - 233 Aligned: 176 Modelled: 177 Confidence: 13.3% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:aquaporin aqpm; PDBTitle: crystal structure of integral membrane protein aquaporin aqpm at 1.68a2 resolution Phyre2 PDB 2xro chain E Region: 490 - 516 Aligned: 27 Modelled: 27 Confidence: 13.2% Identity: 30% PDB header:dna-binding protein/dna Chain: E: PDB Molecule:hth-type transcriptional regulator ttgv; PDBTitle: crystal structure of ttgv in complex with its dna operator Phyre2 PDB 2qap chain A domain 1 Region: 32 - 57 Aligned: 26 Modelled: 26 Confidence: 12.4% Identity: 31% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 1 c2w2eA_ 2 d1j4na_ 3 c4r0cB_ 4 d1fx8a_ 5 c6eu6A_ 6 c2ia2D_ 7 c1ldaA_ 8 c2b6pA_ 9 c4g1uB_ 10 c2g7uB_ 11 c2bruC_ 12 c2nuuF_ 13 d1d4oa_ 14 c1pt9B_ 15 d1pnoa_ 16 c3r4kD_ 17 c1mkmA_ 18 c2f2bA_ 19 c2xroE_ 20 d2qapa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56