1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	N	P	G	F	D	A	V	D	Q	E	T	A	A	A	Q	A	V	A	D	A	H	G	V	P	F	L	G	I	R	G	M	S	D	G	P	G	D	P	L	H	L	P	G	F	P	V	Q	F	F	V	Y	K	Q	I	A	A	N	N	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?				?																							?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.
Sequence		A	R	V	T	E	A	F	L	Q	N	W	A	G	V
Secondary structure
SS confidence
Disorder												?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 58%) Beta strand ( 9%)

Rank Aligned region

PDB 4kn5 chain A Region: 2 - 70 Aligned: 64 Modelled: 69 Confidence: 99.7% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:methylthioadenosine nucleosidase; PDBTitle: crystal structure of a putative methylthioadenosine nucleosidase from2 weissella paramesenteroides atcc 33313 (target nysgrc-029342 ) Phyre2 PDB 5dk6 chain A Region: 3 - 73 Aligned: 66 Modelled: 71 Confidence: 99.6% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of a 5'-methylthioadenosine/s-adenosylhomocysteine2 (mta/sah) nucleosidase (mtan) from colwellia psychrerythraea 34h3 (cps_4743, target psi-029300) in complex with adenine at 2.27 a4 resolution Phyre2 PDB 4l0m chain A Region: 3 - 69 Aligned: 63 Modelled: 67 Confidence: 99.6% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:putative 5'-methylthioadenosine/s-adenosylhomocysteine PDBTitle: crystal structure of a putative 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase from borrelia burgdorferi b31 bound3 to adenine (target nysgrc-029268 ) Phyre2 PDB 4jwt chain A Region: 2 - 71 Aligned: 65 Modelled: 70 Confidence: 99.6% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:methylthioadenosine nucleosidase; PDBTitle: crystal structure of a putative 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase from sulfurimonas denitrificans dsm3 1251 (target nysgrc-029304 ) Phyre2 PDB 4jos chain A Region: 2 - 71 Aligned: 65 Modelled: 70 Confidence: 99.6% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of a putative 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase from francisella philomiragia atcc3 25017 (target nysgrc-029335) Phyre2 PDB 6ayt chain D Region: 2 - 71 Aligned: 65 Modelled: 70 Confidence: 99.6% Identity: 26% PDB header:hydrolase, transferase Chain: D: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of campylobacter jejuni 5'-methylthioadenosine/s-2 adenosyl homocysteine nucleosidase (mtan) complexed with3 pyrazinylthio-dadme-immucillin-a Phyre2 PDB 3nm5 chain B Region: 4 - 71 Aligned: 63 Modelled: 68 Confidence: 99.6% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:mta/sah nucleosidase; PDBTitle: helicobacter pylori mtan complexed with formycin a Phyre2 PDB 4pr3 chain A Region: 2 - 64 Aligned: 58 Modelled: 63 Confidence: 99.6% Identity: 34% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine nucleosidase / s- PDBTitle: crystal structure of brucella melitensis 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase Phyre2 PDB 6if8 chain D Region: 2 - 71 Aligned: 65 Modelled: 70 Confidence: 99.6% Identity: 31% PDB header:hydrolase Chain: D: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: aeromonas hydrophila mtan-2 complexed with adenine Phyre2 PDB 1zos chain E Region: 2 - 71 Aligned: 65 Modelled: 70 Confidence: 99.6% Identity: 32% PDB header:hydrolase Chain: E: PDB Molecule:5'-methylthioadenosine / s-adenosylhomocysteine PDBTitle: structure of 5'-methylthionadenosine/s-adenosylhomocysteine2 nucleosidase from s. pneumoniae with a transition-state inhibitor mt-3 imma Phyre2 PDB 3dp9 chain A Region: 2 - 71 Aligned: 65 Modelled: 70 Confidence: 99.6% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:mta/sah nucleosidase; PDBTitle: crystal structure of vibrio cholerae 5'-methylthioadenosine/s-adenosyl2 homocysteine nucleosidase (mtan) complexed with butylthio-dadme-3 immucillin a Phyre2 PDB 4g41 chain A Region: 2 - 71 Aligned: 65 Modelled: 70 Confidence: 99.6% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:mta/sah nucleosidase; PDBTitle: crystal structure of s-adenosylhomocysteine nucleosidase from2 streptococcus pyogenes in complex with 5-methylthiotubericidin Phyre2 PDB 3bl6 chain A Region: 3 - 71 Aligned: 64 Modelled: 69 Confidence: 99.6% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine nucleosidase/s- PDBTitle: crystal structure of staphylococcus aureus 5'-2 methylthioadenosine/s-adenosylhomocysteine nucleosidase in3 complex with formycin a Phyre2 PDB 6po4 chain A Region: 2 - 73 Aligned: 67 Modelled: 72 Confidence: 99.6% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: 2.1 angstrom resolution crystal structure of 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase (mtnn) from haemophilus influenzae3 pittii. Phyre2 PDB 1jys chain A Region: 3 - 72 Aligned: 61 Modelled: 70 Confidence: 99.6% Identity: 30% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 PDB 4qez chain C Region: 3 - 73 Aligned: 66 Modelled: 71 Confidence: 99.5% Identity: 29% PDB header:hydrolase Chain: C: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of 5'-methylthioadenosine/s-adenosylhomocysteine2 nucleosidase from bacillus anthracis Phyre2 PDB 2h8g chain A Region: 2 - 73 Aligned: 69 Modelled: 72 Confidence: 99.5% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine nucleosidase; PDBTitle: 5'-methylthioadenosine nucleosidase from arabidopsis2 thaliana Phyre2 PDB 3eei chain A Region: 2 - 71 Aligned: 65 Modelled: 70 Confidence: 99.5% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:5-methylthioadenosine nucleosidase/s-adenosylhomocysteine PDBTitle: crystal structure of 5'-methylthioadenosine/s-adenosylhomocysteine2 nucleosidase from neisseria meningitidis in complex with methylthio-3 immucillin-a Phyre2 PDB 3bsf chain B Region: 2 - 69 Aligned: 62 Modelled: 68 Confidence: 99.5% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:at4g34840; PDBTitle: crystal structure of the mta/sah nucleosidase Phyre2 PDB 4qas chain B Region: 4 - 71 Aligned: 63 Modelled: 68 Confidence: 99.4% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:ct263; PDBTitle: 1.27 a resolution structure of ct263-d161n (mtan) from chlamydia2 trachomatis Phyre2 1 c4kn5A_ 2 c5dk6A_ 3 c4l0mA_ 4 c4jwtA_ 5 c4josA_ 6 c6aytD_ 7 c3nm5B_ 8 c4pr3A_ 9 c6if8D_ 10 c1zosE_ 11 c3dp9A_ 12 c4g41A_ 13 c3bl6A_ 14 c6po4A_ 15 d1jysa_ 16 c4qezC_ 17 c2h8gA_ 18 c3eeiA_ 19 c3bsfB_ 20 c4qasB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99