1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	G	A	P	L	R	H	C	L	L	V	A	A	A	L	S	L	G	C	G	V	A	A	A	D	P	G	Y	V	A	N	V	I	P	C	E	Q	R	T	L	V	L	S	A	F	P	A	E	A	D	A	V	L	A	H	T	A	L	D	A
Secondary structure
SS confidence
Disorder		?	?	?	?													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																				?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	P	V	V	V	A	D	R	R	R	Y	Y	L	G	S	I	S	G	K	K	V	I	V	A	M	T	G	I	G	L	V	N	A	T	N	T	T	E	T	A	F	A	R	F	T	C	A	S	S	I	A	I	A	A	V	M	F	S	G	V
Secondary structure
SS confidence
Disorder		?																																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	G	G	A	G	R	T	S	I	G	D	V	A	I	P	A	R	W	T	L	D	N	G	A	T	F	R	G	V	D	P	G	M	L	A	T	A	Q	T	L	S	V	V	L	D	N	I	N	T	L	G	N	P	V	C	L	C	R	N	V
Secondary structure
SS confidence
Disorder																																	?		?				?	?	?						?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	V	V	R	L	N	H	L	G	R	Q	P	Q	L	F	V	G	G	D	G	S	S	S	D	K	N	N	G	Q	A	F	P	C	I	P	N	G	G	S	V	F	A	A	N	P	V	V	H	P	I	A	H	L	A	I	P	V	T	F	S
Secondary structure
SS confidence
Disorder						?	?													?			?	?	?				?														?
Disorder confidence
		.	.	.	.	.	.
Sequence		R	R	R	D	P	G
Secondary structure
SS confidence
Disorder			?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 27%) Beta strand ( 30%)

Rank Aligned region

PDB 4jwt chain A Region: 24 - 241 Aligned: 200 Modelled: 218 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:methylthioadenosine nucleosidase; PDBTitle: crystal structure of a putative 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase from sulfurimonas denitrificans dsm3 1251 (target nysgrc-029304 ) Phyre2 PDB 6ayt chain D Region: 38 - 241 Aligned: 187 Modelled: 204 Confidence: 100.0% Identity: 20% PDB header:hydrolase, transferase Chain: D: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of campylobacter jejuni 5'-methylthioadenosine/s-2 adenosyl homocysteine nucleosidase (mtan) complexed with3 pyrazinylthio-dadme-immucillin-a Phyre2 PDB 4jos chain A Region: 36 - 241 Aligned: 189 Modelled: 205 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of a putative 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase from francisella philomiragia atcc3 25017 (target nysgrc-029335) Phyre2 PDB 5dk6 chain A Region: 31 - 241 Aligned: 193 Modelled: 208 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of a 5'-methylthioadenosine/s-adenosylhomocysteine2 (mta/sah) nucleosidase (mtan) from colwellia psychrerythraea 34h3 (cps_4743, target psi-029300) in complex with adenine at 2.27 a4 resolution Phyre2 PDB 3nm5 chain B Region: 37 - 241 Aligned: 189 Modelled: 205 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:mta/sah nucleosidase; PDBTitle: helicobacter pylori mtan complexed with formycin a Phyre2 PDB 4kn5 chain A Region: 38 - 241 Aligned: 187 Modelled: 202 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:methylthioadenosine nucleosidase; PDBTitle: crystal structure of a putative methylthioadenosine nucleosidase from2 weissella paramesenteroides atcc 33313 (target nysgrc-029342 ) Phyre2 PDB 4l0m chain A Region: 38 - 241 Aligned: 189 Modelled: 203 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:putative 5'-methylthioadenosine/s-adenosylhomocysteine PDBTitle: crystal structure of a putative 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase from borrelia burgdorferi b31 bound3 to adenine (target nysgrc-029268 ) Phyre2 PDB 3dp9 chain A Region: 38 - 241 Aligned: 187 Modelled: 202 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:mta/sah nucleosidase; PDBTitle: crystal structure of vibrio cholerae 5'-methylthioadenosine/s-adenosyl2 homocysteine nucleosidase (mtan) complexed with butylthio-dadme-3 immucillin a Phyre2 PDB 1zos chain E Region: 38 - 241 Aligned: 187 Modelled: 204 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: E: PDB Molecule:5'-methylthioadenosine / s-adenosylhomocysteine PDBTitle: structure of 5'-methylthionadenosine/s-adenosylhomocysteine2 nucleosidase from s. pneumoniae with a transition-state inhibitor mt-3 imma Phyre2 PDB 4g41 chain A Region: 36 - 241 Aligned: 189 Modelled: 206 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:mta/sah nucleosidase; PDBTitle: crystal structure of s-adenosylhomocysteine nucleosidase from2 streptococcus pyogenes in complex with 5-methylthiotubericidin Phyre2 PDB 6if8 chain D Region: 34 - 241 Aligned: 184 Modelled: 208 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: D: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: aeromonas hydrophila mtan-2 complexed with adenine Phyre2 PDB 4qez chain C Region: 38 - 241 Aligned: 184 Modelled: 202 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: C: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of 5'-methylthioadenosine/s-adenosylhomocysteine2 nucleosidase from bacillus anthracis Phyre2 PDB 5b7p chain B Region: 38 - 241 Aligned: 186 Modelled: 202 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:mta/sah nucleosidase; PDBTitle: structures and functional analysis of periplasmic 5-2 methylthioadenosine/s-adenosylhomocysteine nucleosidase from3 aeromonas hydrophila Phyre2 PDB 1jys chain A Region: 38 - 241 Aligned: 187 Modelled: 204 Confidence: 100.0% Identity: 17% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 PDB 6po4 chain A Region: 38 - 241 Aligned: 187 Modelled: 204 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: 2.1 angstrom resolution crystal structure of 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase (mtnn) from haemophilus influenzae3 pittii. Phyre2 PDB 2h8g chain A Region: 37 - 241 Aligned: 179 Modelled: 205 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine nucleosidase; PDBTitle: 5'-methylthioadenosine nucleosidase from arabidopsis2 thaliana Phyre2 PDB 3bl6 chain A Region: 39 - 241 Aligned: 186 Modelled: 203 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine nucleosidase/s- PDBTitle: crystal structure of staphylococcus aureus 5'-2 methylthioadenosine/s-adenosylhomocysteine nucleosidase in3 complex with formycin a Phyre2 PDB 3eei chain A Region: 38 - 241 Aligned: 187 Modelled: 204 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:5-methylthioadenosine nucleosidase/s-adenosylhomocysteine PDBTitle: crystal structure of 5'-methylthioadenosine/s-adenosylhomocysteine2 nucleosidase from neisseria meningitidis in complex with methylthio-3 immucillin-a Phyre2 PDB 3bsf chain B Region: 38 - 241 Aligned: 178 Modelled: 185 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:at4g34840; PDBTitle: crystal structure of the mta/sah nucleosidase Phyre2 PDB 1z34 chain A Region: 33 - 241 Aligned: 190 Modelled: 209 Confidence: 100.0% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:purine nucleoside phosphorylase; PDBTitle: crystal structure of trichomonas vaginalis purine nucleoside2 phosphorylase complexed with 2-fluoro-2'-deoxyadenosine Phyre2 1 c4jwtA_ 2 c6aytD_ 3 c4josA_ 4 c5dk6A_ 5 c3nm5B_ 6 c4kn5A_ 7 c4l0mA_ 8 c3dp9A_ 9 c1zosE_ 10 c4g41A_ 11 c6if8D_ 12 c4qezC_ 13 c5b7pB_ 14 d1jysa_ 15 c6po4A_ 16 c2h8gA_ 17 c3bl6A_ 18 c3eeiA_ 19 c3bsfB_ 20 c1z34A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99