1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	G	A	G	I	V	E	T	T	T	N	R	V	R	H	V	P	V	P	E	P	V	S	E	R	L	R	D	E	L	P	T	E	P	N	A	L	V	F	P	S	Y	R	G	G	H	L	P	I	E	E	Y	R	R	A	F	D	K	G
Secondary structure
SS confidence
Disorder		?	?	?				?	?																																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		C	K	A	V	G	I	A	D	L	V	P	H	G	L	R	H	T	T	A	S	L	A	I	S	A	G	A	N	V	K	V	V	Q	R	L	L	G	H	A	T	A	A	M	T	L	D	R	H	G	H	L	L	S	D	D	L	A	G	V	A
Secondary structure
SS confidence
Disorder																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.
Sequence		G	L	L	V	Q	A	I	K	S	A	A	A	S	L	R	Y	S	D	P	D	S	V	A	V	E	N	I	S	A	A	S
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 49%) Beta strand ( 9%)

Rank Aligned region

PDB 3nkh chain B Region: 9 - 125 Aligned: 117 Modelled: 117 Confidence: 99.9% Identity: 23% PDB header:recombination Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of integrase from mrsa strain staphylococcus aureus Phyre2 PDB 5jjv chain A Region: 5 - 125 Aligned: 120 Modelled: 121 Confidence: 99.9% Identity: 23% PDB header:recombination Chain: A: PDB Molecule:tyrosine recombinase xerh; PDBTitle: crystal structure of xerh site-specific recombinase bound to2 palindromic difh substrate: post-cleavage complex Phyre2 PDB 6en2 chain A Region: 6 - 123 Aligned: 118 Modelled: 118 Confidence: 99.9% Identity: 25% PDB header:recombination Chain: A: PDB Molecule:int protein; PDBTitle: structure of the tn1549 transposon integrase (aa 82-397, r225k) in2 complex with a circular intermediate dna (ci6b-dna) Phyre2 PDB 5dcf chain A Region: 2 - 120 Aligned: 118 Modelled: 119 Confidence: 99.9% Identity: 29% PDB header:recombination Chain: A: PDB Molecule:tyrosine recombinase xerd,dna translocase ftsk; PDBTitle: c-terminal domain of xerd recombinase in complex with gamma domain of2 ftsk Phyre2 PDB 5vfz chain A Region: 2 - 124 Aligned: 118 Modelled: 123 Confidence: 99.9% Identity: 20% PDB header:dna binding protein Chain: A: PDB Molecule:gp33; PDBTitle: integrase from mycobacterium phage brujita Phyre2 PDB 2a3v chain A Region: 8 - 123 Aligned: 112 Modelled: 116 Confidence: 99.8% Identity: 26% PDB header:recombination Chain: A: PDB Molecule:site-specific recombinase inti4; PDBTitle: structural basis for broad dna-specificity in integron recombination Phyre2 PDB 5hxy chain E Region: 5 - 122 Aligned: 117 Modelled: 118 Confidence: 99.8% Identity: 26% PDB header:recombination Chain: E: PDB Molecule:tyrosine recombinase xera; PDBTitle: crystal structure of xera recombinase Phyre2 PDB 1ma7 chain A Region: 7 - 124 Aligned: 117 Modelled: 118 Confidence: 99.8% Identity: 12% PDB header:hydrolase, ligase/dna Chain: A: PDB Molecule:cre recombinase; PDBTitle: crystal structure of cre site-specific recombinase2 complexed with a mutant dna substrate, loxp-a8/t27 Phyre2 PDB 1aih chain A Region: 6 - 122 Aligned: 104 Modelled: 117 Confidence: 99.8% Identity: 24% Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Lambda integrase-like, catalytic core Phyre2 PDB 1z1b chain A Region: 6 - 108 Aligned: 102 Modelled: 103 Confidence: 99.7% Identity: 23% PDB header:dna binding protein/dna Chain: A: PDB Molecule:integrase; PDBTitle: crystal structure of a lambda integrase dimer bound to a2 coc' core site Phyre2 PDB 1crx chain A Region: 7 - 124 Aligned: 117 Modelled: 118 Confidence: 99.7% Identity: 13% PDB header:replication/dna Chain: A: PDB Molecule:cre recombinase; PDBTitle: cre recombinase/dna complex reaction intermediate i Phyre2 PDB 5c6k chain B Region: 3 - 121 Aligned: 108 Modelled: 119 Confidence: 99.7% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:integrase; PDBTitle: bacteriophage p2 integrase catalytic domain Phyre2 PDB 1a0p chain A Region: 2 - 120 Aligned: 116 Modelled: 119 Confidence: 99.7% Identity: 23% PDB header:dna recombination Chain: A: PDB Molecule:site-specific recombinase xerd; PDBTitle: site-specific recombinase, xerd Phyre2 PDB 4a8e chain A Region: 5 - 114 Aligned: 109 Modelled: 110 Confidence: 99.6% Identity: 21% PDB header:cell cycle Chain: A: PDB Molecule:probable tyrosine recombinase xerc-like; PDBTitle: the structure of a dimeric xer recombinase from archaea Phyre2 PDB 1p7d chain A Region: 6 - 114 Aligned: 107 Modelled: 109 Confidence: 99.6% Identity: 21% Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Lambda integrase-like, catalytic core Phyre2 PDB 3uxu chain A Region: 34 - 129 Aligned: 95 Modelled: 96 Confidence: 99.6% Identity: 13% PDB header:recombination Chain: A: PDB Molecule:probable integrase; PDBTitle: the structure of the catalytic domain of the sulfolobus spindle-shaped2 viral integrase reveals an evolutionarily conserved catalytic core3 and supports a mechanism of dna cleavage in trans Phyre2 PDB 1f44 chain A domain 2 Region: 2 - 124 Aligned: 122 Modelled: 123 Confidence: 99.5% Identity: 15% Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Lambda integrase-like, catalytic core Phyre2 PDB 1a0p chain A domain 2 Region: 2 - 120 Aligned: 116 Modelled: 119 Confidence: 99.5% Identity: 28% Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Lambda integrase-like, catalytic core Phyre2 PDB 1ae9 chain A Region: 6 - 111 Aligned: 104 Modelled: 106 Confidence: 99.4% Identity: 20% Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Lambda integrase-like, catalytic core Phyre2 PDB 5crx chain B domain 2 Region: 10 - 97 Aligned: 88 Modelled: 88 Confidence: 99.0% Identity: 13% Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Lambda integrase-like, catalytic core Phyre2 1 c3nkhB_ 2 c5jjvA_ 3 c6en2A_ 4 c5dcfA_ 5 c5vfzA_ 6 c2a3vA_ 7 c5hxyE_ 8 c1ma7A_ 9 d1aiha_ 10 c1z1bA_ 11 c1crxA_ 12 c5c6kB_ 13 c1a0pA_ 14 c4a8eA_ 15 d1p7da_ 16 c3uxuA_ 17 d1f44a2 18 d1a0pa2 19 d1ae9a_ 20 d5crxb2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60