1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	P	T	G	Q	A	V	D	V	A	V	R	E	G	A	G	D	V	G	Y	S	V	E	R	E	N	L	P	A	D	D	P	V	R	N	G	N	R	W	R	V	I	A	V	D	T	E	H	H	R	I	A	A	R	R	L	G	D	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	R	A	A	F	S	G	D	Y	L	H	E	H	I	T	H	G	Y	A	I	T	V	H	A	S	Q	G	T	T	A	H	S	T	H	A	V	L	G	D	N	T	S	R	A	T	L	Y	V	A	M	T	P	A	R	E	S	N	T	A	Y
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.
Sequence		L	C	E	R	T	A	G	E	G	A	R	V	D	L	A	G	W	D	L	W	V	S	G	K	A	E	A	M	S	D	E	K	S	A	S	P	V	W	C	R	V	G	A	R	C	D	H	R	G	K	R	S	C	W
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?					?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?		?	?	?					?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 9%) Beta strand ( 43%)

Rank Aligned region

PDB 5ld2 chain D Region: 19 - 131 Aligned: 110 Modelled: 113 Confidence: 99.9% Identity: 24% PDB header:hydrolase Chain: D: PDB Molecule:recbcd enzyme subunit recd; PDBTitle: cryo-em structure of recbcd+dna complex revealing activated nuclease2 domain Phyre2 PDB 3e1s chain A Region: 19 - 131 Aligned: 108 Modelled: 113 Confidence: 99.8% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:exodeoxyribonuclease v, subunit recd; PDBTitle: structure of an n-terminal truncation of deinococcus radiodurans recd2 Phyre2 PDB 5n8o chain A Region: 19 - 125 Aligned: 105 Modelled: 107 Confidence: 99.8% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:dna helicase i; PDBTitle: cryo em structure of the conjugative relaxase trai of the f/r1 plasmid2 system Phyre2 PDB 3gp8 chain A Region: 10 - 131 Aligned: 109 Modelled: 122 Confidence: 99.8% Identity: 26% PDB header:hydrolase/dna Chain: A: PDB Molecule:exodeoxyribonuclease v, subunit recd, putative; PDBTitle: crystal structure of the binary complex of recd2 with dna Phyre2 PDB 5ftb chain A Region: 20 - 121 Aligned: 99 Modelled: 102 Confidence: 99.7% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:tpr domain protein; PDBTitle: crystal structure of pif1 helicase from bacteroides in2 complex with amppnp Phyre2 PDB 5fhh chain A Region: 23 - 121 Aligned: 99 Modelled: 99 Confidence: 99.6% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:atp-dependent dna helicase pif1; PDBTitle: structure of human pif1 helicase domain residues 200-641 Phyre2 PDB 1w36 chain G Region: 73 - 131 Aligned: 59 Modelled: 59 Confidence: 99.6% Identity: 29% PDB header:recombination Chain: G: PDB Molecule:exodeoxyribonuclease v alpha chain; PDBTitle: recbcd:dna complex Phyre2 PDB 1w36 chain D domain 2 Region: 73 - 131 Aligned: 59 Modelled: 59 Confidence: 99.5% Identity: 29% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Tandem AAA-ATPase domain Phyre2 PDB 4l0j chain A Region: 19 - 97 Aligned: 74 Modelled: 79 Confidence: 99.5% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:dna helicase i; PDBTitle: structure of a translocation signal domain mediating conjugative2 transfer by type iv secretion systems Phyre2 PDB 5o6d chain B Region: 73 - 122 Aligned: 50 Modelled: 50 Confidence: 99.4% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:atp-dependent dna helicase pif1; PDBTitle: structure of scpif1 in complex with polydt and atpgs Phyre2 PDB 3upu chain C Region: 73 - 119 Aligned: 47 Modelled: 47 Confidence: 99.1% Identity: 21% PDB header:hydrolase/dna Chain: C: PDB Molecule:atp-dependent dna helicase dda; PDBTitle: crystal structure of the t4 phage sf1b helicase dda Phyre2 PDB 4n0o chain C Region: 78 - 120 Aligned: 43 Modelled: 43 Confidence: 98.9% Identity: 26% PDB header:hydrolase/dna Chain: C: PDB Molecule:replicase polyprotein 1ab; PDBTitle: complex structure of arterivirus nonstructural protein 10 (helicase)2 with dna Phyre2 PDB 5wwp chain A Region: 78 - 131 Aligned: 54 Modelled: 54 Confidence: 98.7% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:orf1ab; PDBTitle: crystal structure of middle east respiratory syndrome coronavirus2 helicase (mers-cov nsp13) Phyre2 PDB 5wwp chain B Region: 78 - 120 Aligned: 43 Modelled: 43 Confidence: 98.7% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:orf1ab; PDBTitle: crystal structure of middle east respiratory syndrome coronavirus2 helicase (mers-cov nsp13) Phyre2 PDB 3dmn chain A Region: 78 - 125 Aligned: 48 Modelled: 48 Confidence: 98.6% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative dna helicase; PDBTitle: the crystal structure of the c-terminal domain of a possilbe dna2 helicase from lactobacillus plantarun wcfs1 Phyre2 PDB 1pjr chain A Region: 79 - 140 Aligned: 62 Modelled: 62 Confidence: 98.4% Identity: 19% PDB header:helicase Chain: A: PDB Molecule:pcra; PDBTitle: structure of dna helicase Phyre2 PDB 4c30 chain I Region: 79 - 140 Aligned: 62 Modelled: 62 Confidence: 98.3% Identity: 21% PDB header:hydrolase/dna Chain: I: PDB Molecule:dna helicase ii; PDBTitle: crystal structure of deinococcus radiodurans uvrd in2 complex with dna, form 2 Phyre2 PDB 1w36 chain B domain 2 Region: 80 - 137 Aligned: 58 Modelled: 58 Confidence: 98.3% Identity: 22% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Tandem AAA-ATPase domain Phyre2 PDB 1uaa chain B Region: 80 - 123 Aligned: 44 Modelled: 44 Confidence: 98.3% Identity: 34% PDB header:hydrolase/dna Chain: B: PDB Molecule:protein (atp-dependent dna helicase rep.); PDBTitle: e. coli rep helicase/dna complex Phyre2 PDB 1qhh chain D Region: 80 - 151 Aligned: 72 Modelled: 72 Confidence: 98.3% Identity: 18% PDB header:hydrolase Chain: D: PDB Molecule:protein (pcra (subunit)); PDBTitle: structure of dna helicase with adpnp Phyre2 1 c5ld2D_ 2 c3e1sA_ 3 c5n8oA_ 4 c3gp8A_ 5 c5ftbA_ 6 c5fhhA_ 7 c1w36G_ 8 d1w36d2 9 c4l0jA_ 10 c5o6dB_ 11 c3upuC_ 12 c4n0oC_ 13 c5wwpA_ 14 c5wwpB_ 15 c3dmnA_ 16 c1pjrA_ 17 c4c30I_ 18 d1w36b2 19 c1uaaB_ 20 c1qhhD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70