1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	E	P	Q	H	A	V	N	I	V	L	K	E	A	A	R	S	G	R	A	D	E	T	M	V	L	V	T	E	K	V	E	A	T	L	R	W	A	G	N	S	M	T	T	N	G	V	S	H	S	R	N	V	T	V	I	S	I	V
Secondary structure
SS confidence
Disorder		?	?	?																													?								?	?					?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	R	G	D	S	A	F	V	G	S	V	V	S	A	E	V	D	P	S	V	L	P	G	L	V	V	S	S	Q	D	A	A	R	S	A	P	E	A	G	D	A	A	P	L	L	A	D	T	G	E	P	D	D	W	D	A	P	V	P	G
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	G	A	G	V	F	T	G	I	A	G	S	L	S	R	G	F	R	G	A	D	R	L	Y	G	Y	A	H	R	S	V	S	T	T	F	L	A	S	S	T	G	L	R	R	R	Y	T	Q	P	T	G	A	I	E	I	N	A	K	R	G
Secondary structure
SS confidence
Disorder		?	?														?	?	?	?																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	A	S	A	W	V	G	I	G	T	P	D	F	V	E	V	P	I	D	L	M	L	E	R	L	S	T	R	L	R	W	A	Q	R	T	V	E	L	P	A	G	R	Y	Q	T	I	M	P	P	S	T	V	A	D	M	M	I	Y	L	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?																							?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		W	S	M	A	G	R	G	A	Q	E	G	R	T	A	F	S	A	P	G	G	G	T	R	V	G	E	R	L	T	E	L	P	L	T	L	F	T	D	P	A	A	P	G	L	A	C	T	P	F	V	A	V	S	N	S	S	E	T	Q	S
Secondary structure
SS confidence
Disorder												?				?	?	?	?	?	?	?	?	?	?																										?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	F	D	N	G	M	E	I	S	Q	V	D	W	I	R	S	G	V	I	N	A	L	A	Y	P	R	A	T	A	A	K	F	D	A	P	V	A	V	A	A	D	N	L	I	M	T	G	G	S	A	D	L	A	D	M	I	A	G	T	E
Secondary structure
SS confidence
Disorder																																				?	?		?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	G	L	L	L	T	T	L	W	Y	I	R	E	V	D	P	T	T	L	L	L	T	G	L	T	R	D	G	V	Y	L	V	E	D	G	E	V	S	A	A	V	N	N	F	R	F	N	E	S	P	L	D	L	L	R	R	A	T	E	A
Secondary structure
SS confidence
Disorder											?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.
Sequence		G	V	S	E	P	T	L	P	R	E	W	S	D	W	V	T	R	T	A	M	P	P	L	R	I	P	D	F	H	M	S	S	V	S	Q	A	Q
Secondary structure
SS confidence
Disorder					?						?	?		?	?	?	?		?		?	?										?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 23%) Beta strand ( 40%)

Rank Aligned region

PDB 1vpb chain A Region: 1 - 453 Aligned: 419 Modelled: 441 Confidence: 100.0% Identity: 15% Fold: Putative modulator of DNA gyrase, PmbA/TldD Superfamily: Putative modulator of DNA gyrase, PmbA/TldD Family: Putative modulator of DNA gyrase, PmbA/TldD Phyre2 PDB 5nja chain C Region: 2 - 454 Aligned: 429 Modelled: 453 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: C: PDB Molecule:metalloprotease tldd; PDBTitle: e. coli microcin-processing metalloprotease tldd/e with angiotensin2 analogue bound Phyre2 PDB 1vl4 chain A Region: 3 - 451 Aligned: 413 Modelled: 441 Confidence: 100.0% Identity: 15% Fold: Putative modulator of DNA gyrase, PmbA/TldD Superfamily: Putative modulator of DNA gyrase, PmbA/TldD Family: Putative modulator of DNA gyrase, PmbA/TldD Phyre2 PDB 3qtd chain C Region: 1 - 452 Aligned: 420 Modelled: 448 Confidence: 100.0% Identity: 16% PDB header:gene regulation Chain: C: PDB Molecule:pmba protein; PDBTitle: crystal structure of putative modulator of gyrase (pmba) from2 pseudomonas aeruginosa pao1 Phyre2 PDB 1o12 chain A domain 1 Region: 374 - 399 Aligned: 21 Modelled: 26 Confidence: 49.5% Identity: 38% Fold: Composite domain of metallo-dependent hydrolases Superfamily: Composite domain of metallo-dependent hydrolases Family: N-acetylglucosamine-6-phosphate deacetylase, NagA Phyre2 PDB 1m1h chain A domain 1 Region: 380 - 398 Aligned: 19 Modelled: 19 Confidence: 35.7% Identity: 37% Fold: N-utilization substance G protein NusG, insert domain Superfamily: N-utilization substance G protein NusG, insert domain Family: N-utilization substance G protein NusG, insert domain Phyre2 PDB 1xcc chain A Region: 383 - 447 Aligned: 65 Modelled: 65 Confidence: 32.1% Identity: 14% Fold: Thioredoxin fold Superfamily: Thioredoxin-like Family: Glutathione peroxidase-like Phyre2 PDB 2i81 chain B Region: 388 - 431 Aligned: 44 Modelled: 44 Confidence: 30.0% Identity: 25% PDB header:oxidoreductase Chain: B: PDB Molecule:2-cys peroxiredoxin; PDBTitle: crystal structure of plasmodium vivax 2-cys peroxiredoxin,2 reduced Phyre2 PDB 3tkp chain B Region: 383 - 448 Aligned: 66 Modelled: 66 Confidence: 29.0% Identity: 17% PDB header:oxidoreductase Chain: B: PDB Molecule:peroxiredoxin-4; PDBTitle: crystal structure of full-length human peroxiredoxin 4 in the reduced2 form Phyre2 PDB 4qlp chain B Region: 289 - 320 Aligned: 32 Modelled: 32 Confidence: 27.4% Identity: 16% PDB header:hydrolase/protein binding Chain: B: PDB Molecule:alanine and proline rich protein, tuberculosis necrotizing PDBTitle: atomic structure of tuberculosis necrotizing toxin (tnt) complexed2 with its immunity factor ift Phyre2 PDB 2h01 chain A domain 1 Region: 389 - 431 Aligned: 43 Modelled: 43 Confidence: 23.4% Identity: 26% Fold: Thioredoxin fold Superfamily: Thioredoxin-like Family: Glutathione peroxidase-like Phyre2 PDB 2v2g chain C Region: 383 - 443 Aligned: 61 Modelled: 61 Confidence: 22.2% Identity: 15% PDB header:oxidoreductase Chain: C: PDB Molecule:peroxiredoxin 6; PDBTitle: crystal structure of the c45s mutant of the peroxiredoxin 62 of arenicola marina. monoclinic form Phyre2 PDB 5ykj chain A Region: 388 - 443 Aligned: 56 Modelled: 56 Confidence: 21.1% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:peroxiredoxin prx1, mitochondrial; PDBTitle: structural basis of the thiol resolving mechanism in yeast2 mitochondrial 1-cys peroxiredoxin via glutathione/thioredoxin systems Phyre2 PDB 2vjw chain A Region: 3 - 39 Aligned: 37 Modelled: 37 Confidence: 20.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:gaf family protein; PDBTitle: crystal structure of the second gaf domain of devs from2 mycobacterium smegmatis Phyre2 PDB 5ine chain A Region: 366 - 395 Aligned: 25 Modelled: 30 Confidence: 19.9% Identity: 28% PDB header:viral protein Chain: A: PDB Molecule:pre-glycoprotein polyprotein gp complex; PDBTitle: crystal structure of the prefusion glycoprotein of lcmv Phyre2 PDB 6feu chain J Region: 388 - 442 Aligned: 55 Modelled: 55 Confidence: 19.1% Identity: 15% PDB header:oxidoreductase Chain: J: PDB Molecule:peroxiredoxin; PDBTitle: prxq2, a 1-cys peroxiredoxin of the thermo-acidophilic archaeon2 sulfolobus islandicus Phyre2 PDB 3gzk chain A Region: 375 - 414 Aligned: 37 Modelled: 40 Confidence: 18.1% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:cellulase; PDBTitle: structure of a. acidocaldarius cellulase cela Phyre2 PDB 1pd0 chain A domain 4 Region: 384 - 396 Aligned: 13 Modelled: 13 Confidence: 15.9% Identity: 38% Fold: Gelsolin-like Superfamily: C-terminal, gelsolin-like domain of Sec23/24 Family: C-terminal, gelsolin-like domain of Sec23/24 Phyre2 PDB 5vk2 chain A Region: 366 - 395 Aligned: 25 Modelled: 30 Confidence: 15.2% Identity: 32% PDB header:viral protein/immune system Chain: A: PDB Molecule:pre-glycoprotein polyprotein gp complex; PDBTitle: structural basis for antibody-mediated neutralization of lassa virus Phyre2 PDB 4nk8 chain A Region: 277 - 398 Aligned: 116 Modelled: 122 Confidence: 14.9% Identity: 16% PDB header:isomerase Chain: A: PDB Molecule:poly(beta-d-mannuronate) c5 epimerase; PDBTitle: crystal structure of the periplasmic alginate epimerase algg d317a2 mutant Phyre2 1 d1vpba_ 2 c5njaC_ 3 d1vl4a_ 4 c3qtdC_ 5 d1o12a1 6 d1m1ha1 7 d1xcca_ 8 c2i81B_ 9 c3tkpB_ 10 c4qlpB_ 11 d2h01a1 12 c2v2gC_ 13 c5ykjA_ 14 c2vjwA_ 15 c5ineA_ 16 c6feuJ_ 17 c3gzkA_ 18 d1pd0a4 19 c5vk2a_ 20 c4nk8A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84