1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	P	N	R	G	I	D	E	D	F	L	D	L	P	R	Q	Q	L	A	D	A	A	L	S	A	A	A	T	A	G	A	S	H	A	D	L	R	V	H	R	I	S	T	E	I	I	Q	L	R	D	G	E	L	E	T	A	V	I	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																																		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	E	L	G	L	A	V	R	V	I	V	A	G	T	W	G	F	A	S	H	A	E	L	A	P	D	V	A	A	A	T	A	R	H	A	V	H	V	A	T	V	L	A	A	L	N	T	E	R	V	R	L	A	P	E	P	V	Y	T	D
Secondary structure
SS confidence
Disorder		?	?																																								?	?	?	?	?	?	?	?								?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	E	W	V	S	N	Y	R	I	D	P	F	G	V	P	A	S	E	K	I	A	V	L	R	D	Y	S	G	R	L	L	D	A	D	G	I	D	H	V	S	A	S	L	N	A	V	K	E	Q	T	F	Y	A	D	T	F	G	S	S	I
Secondary structure
SS confidence
Disorder												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	Q	Q	R	V	R	L	L	P	C	L	D	A	V	A	V	D	S	A	A	G	N	F	E	S	M	R	T	L	A	P	P	T	A	R	G	W	E	V	V	A	G	D	E	I	W	N	W	T	D	E	L	A	Q	L	P	S	L	L	A
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	K	V	R	A	P	S	V	M	P	G	P	T	D	L	V	I	D	P	T	N	L	W	L	T	I	H	E	S	I	G	H	A	T	E	Y	D	R	A	I	G	Y	E	A	A	Y	A	G	T	S	F	A	T	P	D	K	L	G	T	L
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?																										?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		R	Y	G	S	P	V	M	N	V	T	A	D	R	T	A	E	F	G	L	A	T	V	G	Y	D	D	E	G	V	A	A	Q	S	W	D	L	V	R	D	G	V	F	V	G	Y	Q	L	D	R	A	F	A	P	R	L	G	E	P	R	S
Secondary structure
SS confidence
Disorder																																																								?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		N	G	C	S	Y	A	D	S	P	H	H	V	P	I	Q	R	M	A	N	I	S	L	Q	P	G	I	E	D	L	S	T	A	D	L	I	G	R	V	D	D	G	I	Y	I	V	G	D	K	S	W	S	I	D	M	Q	R	Y	N	F	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?			?														?	?																						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		F	T	G	Q	R	F	F	R	I	R	G	G	Q	L	Y	G	Q	L	R	D	V	A	Y	Q	S	S	T	T	D	F	W	N	A	M	E	A	V	G	G	P	S	T	W	R	M	G	G	A	I	N	C	G	K	A	Q	P	G	Q	V	A
Secondary structure
SS confidence
Disorder																																																	?								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.
Sequence		A	V	S	H	G	C	P	S	A	L	F	R	G	V	N	V	L	N	T	R	T	E	G	G	R
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 26%) Beta strand ( 36%)

Rank Aligned region

PDB 5nja chain C Region: 14 - 500 Aligned: 465 Modelled: 487 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: C: PDB Molecule:metalloprotease tldd; PDBTitle: e. coli microcin-processing metalloprotease tldd/e with angiotensin2 analogue bound Phyre2 PDB 1vpb chain A Region: 11 - 498 Aligned: 435 Modelled: 450 Confidence: 100.0% Identity: 17% Fold: Putative modulator of DNA gyrase, PmbA/TldD Superfamily: Putative modulator of DNA gyrase, PmbA/TldD Family: Putative modulator of DNA gyrase, PmbA/TldD Phyre2 PDB 3qtd chain C Region: 1 - 498 Aligned: 439 Modelled: 466 Confidence: 100.0% Identity: 17% PDB header:gene regulation Chain: C: PDB Molecule:pmba protein; PDBTitle: crystal structure of putative modulator of gyrase (pmba) from2 pseudomonas aeruginosa pao1 Phyre2 PDB 1vl4 chain A Region: 15 - 497 Aligned: 425 Modelled: 466 Confidence: 100.0% Identity: 16% Fold: Putative modulator of DNA gyrase, PmbA/TldD Superfamily: Putative modulator of DNA gyrase, PmbA/TldD Family: Putative modulator of DNA gyrase, PmbA/TldD Phyre2 PDB 4b6c chain B Region: 8 - 52 Aligned: 43 Modelled: 45 Confidence: 47.8% Identity: 23% PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b,dna gyrase subunit b,dna gyrase PDBTitle: structure of the m. smegmatis gyrb atpase domain in complex with an2 aminopyrazinamide Phyre2 PDB 4lhd chain B Region: 16 - 131 Aligned: 115 Modelled: 116 Confidence: 39.1% Identity: 12% PDB header:oxidoreductase Chain: B: PDB Molecule:glycine dehydrogenase [decarboxylating]; PDBTitle: crystal structure of synechocystis sp. pcc 6803 glycine decarboxylase2 (p-protein), holo form with pyridoxal-5'-phosphate and glycine,3 closed flexible loop Phyre2 PDB 1s14 chain A Region: 8 - 52 Aligned: 41 Modelled: 45 Confidence: 34.2% Identity: 22% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: DNA gyrase/MutL, N-terminal domain Phyre2 PDB 1w7v chain D Region: 358 - 432 Aligned: 65 Modelled: 75 Confidence: 31.5% Identity: 20% PDB header:hydrolase Chain: D: PDB Molecule:xaa-pro aminopeptidase; PDBTitle: znmg substituted aminopeptidase p from e. coli Phyre2 PDB 1bkn chain A Region: 17 - 52 Aligned: 32 Modelled: 36 Confidence: 29.5% Identity: 28% PDB header:dna repair Chain: A: PDB Molecule:mutl; PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl Phyre2 PDB 1ydu chain A domain 1 Region: 385 - 447 Aligned: 60 Modelled: 63 Confidence: 27.6% Identity: 10% Fold: At5g01610-like Superfamily: At5g01610-like Family: At5g01610-like Phyre2 PDB 3onr chain I Region: 385 - 434 Aligned: 50 Modelled: 50 Confidence: 27.4% Identity: 14% PDB header:metal binding protein Chain: I: PDB Molecule:protein transport protein sece2; PDBTitle: crystal structure of the calcium chelating immunodominant antigen,2 calcium dodecin (rv0379),from mycobacterium tuberculosis with a novel3 calcium-binding site Phyre2 PDB 3g7b chain B Region: 6 - 52 Aligned: 45 Modelled: 47 Confidence: 25.5% Identity: 16% PDB header:isomerase/isomerase inhibitor Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: staphylococcus aureus gyrase b co-complex with methyl ({5-[4-(4-2 hydroxypiperidin-1-yl)-2-phenyl-1,3-thiazol-5-yl]-1h-pyrazol-3-3 yl}methyl)carbamate inhibitor Phyre2 PDB 4k59 chain A Region: 379 - 412 Aligned: 31 Modelled: 34 Confidence: 25.3% Identity: 26% PDB header:rna binding protein Chain: A: PDB Molecule:rna binding protein rsmf; PDBTitle: crystal structure of pseudomonas aeruginosa rsmf Phyre2 PDB 3zm7 chain E Region: 6 - 52 Aligned: 45 Modelled: 47 Confidence: 23.6% Identity: 16% PDB header:isomerase Chain: E: PDB Molecule:dna gyrase subunit b; PDBTitle: crystal structure of the atpase region of mycobacterium2 tuberculosis gyrb with amppcp Phyre2 PDB 3qkb chain B Region: 9 - 45 Aligned: 36 Modelled: 37 Confidence: 21.8% Identity: 6% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a protein with unknown function which belongs to2 pfam duf74 family (pepe_0654) from pediococcus pentosaceus atcc 257453 at 2.73 a resolution Phyre2 PDB 3dx5 chain A Region: 20 - 160 Aligned: 126 Modelled: 141 Confidence: 21.6% Identity: 10% PDB header:lyase Chain: A: PDB Molecule:uncharacterized protein asbf; PDBTitle: crystal structure of the probable 3-dhs dehydratase asbf involved in2 the petrobactin synthesis from bacillus anthracis Phyre2 PDB 1o12 chain A domain 1 Region: 412 - 436 Aligned: 21 Modelled: 25 Confidence: 21.0% Identity: 19% Fold: Composite domain of metallo-dependent hydrolases Superfamily: Composite domain of metallo-dependent hydrolases Family: N-acetylglucosamine-6-phosphate deacetylase, NagA Phyre2 PDB 2pju chain A domain 1 Region: 66 - 102 Aligned: 37 Modelled: 37 Confidence: 20.6% Identity: 11% Fold: Chelatase-like Superfamily: PrpR receptor domain-like Family: PrpR receptor domain-like Phyre2 PDB 5k39 chain A Region: 302 - 417 Aligned: 104 Modelled: 116 Confidence: 20.2% Identity: 13% PDB header:structural protein Chain: A: PDB Molecule:cellulosome anchoring protein cohesin region; PDBTitle: the type ii cohesin dockerin complex from clostridium thermocellum Phyre2 PDB 4emv chain A Region: 6 - 48 Aligned: 43 Modelled: 43 Confidence: 17.0% Identity: 16% PDB header:isomerase/isomerase inhibitor Chain: A: PDB Molecule:dna topoisomerase iv, b subunit; PDBTitle: crystal structure of a topoisomerase atp inhibitor Phyre2 1 c5njaC_ 2 d1vpba_ 3 c3qtdC_ 4 d1vl4a_ 5 c4b6cB_ 6 c4lhdB_ 7 d1s14a_ 8 c1w7vD_ 9 c1bknA_ 10 d1ydua1 11 c3onrI_ 12 c3g7bB_ 13 c4k59A_ 14 c3zm7E_ 15 c3qkbB_ 16 c3dx5A_ 17 d1o12a1 18 d2pjua1 19 c5k39A_ 20 c4emvA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89