1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	T	S	A	P	A	R	N	G	T	R	R	P	S	R	P	I	V	L	L	I	P	V	P	G	S	S	V	I	H	D	L	W	A	G	T	K	L	L	V	V	F	G	I	S	V	L	L	T	F	Y	P	G	W	V	T	I	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	M	A	A	L	V	L	A	A	A	R	I	A	H	I	P	R	G	A	L	P	S	V	P	R	W	L	W	I	V	L	A	I	G	F	L	T	A	A	L	A	G	G	T	P	V	V	A	V	G	G	V	Q	L	G	L	G	G	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	F	L	R	I	T	A	L	S	V	V	L	L	A	L	G	A	M	V	S	W	T	T	N	V	A	E	I	S	P	A	V	A	T	L	G	R	P	F	R	V	L	R	I	P	V	D	E	W	A	V	A	L	A	L	A	L	R	A	F
Secondary structure
SS confidence
Disorder																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	M	L	I	D	E	F	Q	V	L	Y	A	A	R	R	L	R	P	K	R	M	P	P	S	R	K	A	R	R	Q	R	H	A	R	E	L	I	D	L	L	A	A	A	I	T	V	T	L	R	R	A	D	E	M	G	D	A	I	T	A
Secondary structure
SS confidence
Disorder																		?	?			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.
Sequence		R	G	G	T	G	Q	L	S	A	H	P	G	R	P	K	L	A	D	W	V	T	L	A	I	T	A	M	A	S	G	T	A	V	A	I	E	S	L	I	L	H	S
Secondary structure
SS confidence
Disorder								?		?				?																											?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 73%) Beta strand ( 2%) TM helix ( 44%) (View membrane topology prediction)

Rank Aligned region

PDB 5d7t chain H Region: 24 - 273 Aligned: 247 Modelled: 250 Confidence: 100.0% Identity: 18% PDB header:transport protein Chain: H: PDB Molecule:energy-coupling factor transporter transmembrane protein PDBTitle: folate ecf transporter: apo state Phyre2 PDB 4huq chain T Region: 24 - 274 Aligned: 239 Modelled: 251 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: T: PDB Molecule:energy-coupling factor transporter transmembrane protein PDBTitle: crystal structure of a transporter Phyre2 PDB 4rfs chain T Region: 32 - 267 Aligned: 231 Modelled: 232 Confidence: 100.0% Identity: 19% PDB header:hydrolase, transport protein Chain: T: PDB Molecule:energy-coupling factor transporter transmembrane protein PDBTitle: structure of a pantothenate energy coupling factor transporter Phyre2 PDB 5x3x chain Q Region: 28 - 273 Aligned: 227 Modelled: 246 Confidence: 100.0% Identity: 20% PDB header:transport protein Chain: Q: PDB Molecule:uncharacterized protein cbiq; PDBTitle: 2.8a resolution structure of a cobalt energy-coupling factor2 transporter-cbimqo Phyre2 PDB 3hd7 chain A Region: 229 - 282 Aligned: 52 Modelled: 54 Confidence: 17.9% Identity: 12% PDB header:exocytosis Chain: A: PDB Molecule:vesicle-associated membrane protein 2; PDBTitle: helical extension of the neuronal snare complex into the membrane,2 spacegroup c 1 2 1 Phyre2 PDB 2xzm chain L Region: 24 - 36 Aligned: 13 Modelled: 13 Confidence: 17.5% Identity: 23% PDB header:ribosome Chain: L: PDB Molecule:40s ribosomal protein s12; PDBTitle: crystal structure of the eukaryotic 40s ribosomal2 subunit in complex with initiation factor 1. this file3 contains the 40s subunit and initiation factor for4 molecule 1 Phyre2 PDB 1s1h chain L Region: 24 - 36 Aligned: 13 Modelled: 13 Confidence: 17.3% Identity: 15% PDB header:ribosome Chain: L: PDB Molecule:40s ribosomal protein s23; PDBTitle: structure of the ribosomal 80s-eef2-sordarin complex from yeast2 obtained by docking atomic models for rna and protein components into3 a 11.7 a cryo-em map. this file, 1s1h, contains 40s subunit. the 60s4 ribosomal subunit is in file 1s1i. Phyre2 PDB 3u5g chain X Region: 24 - 35 Aligned: 12 Modelled: 12 Confidence: 14.6% Identity: 17% PDB header:ribosome Chain: X: PDB Molecule:40s ribosomal protein s23-a; PDBTitle: the structure of the eukaryotic ribosome at 3.0 a resolution. this2 entry contains proteins of the 40s subunit, ribosome b Phyre2 PDB 1k4t chain A domain 2 Region: 10 - 43 Aligned: 30 Modelled: 34 Confidence: 13.5% Identity: 20% Fold: DNA breaking-rejoining enzymes Superfamily: DNA breaking-rejoining enzymes Family: Eukaryotic DNA topoisomerase I, catalytic core Phyre2 PDB 3j20 chain N Region: 24 - 35 Aligned: 12 Modelled: 12 Confidence: 12.9% Identity: 25% PDB header:ribosome Chain: N: PDB Molecule:30s ribosomal protein s12p; PDBTitle: promiscuous behavior of proteins in archaeal ribosomes revealed by2 cryo-em: implications for evolution of eukaryotic ribosomes (30s3 ribosomal subunit) Phyre2 PDB 2zkq chain L Region: 24 - 36 Aligned: 13 Modelled: 13 Confidence: 12.2% Identity: 15% PDB header:ribosomal protein/rna Chain: L: PDB Molecule: PDBTitle: structure of a mammalian ribosomal 40s subunit within an 80s complex2 obtained by docking homology models of the rna and proteins into an3 8.7 a cryo-em map Phyre2 PDB 3zey chain S Region: 24 - 35 Aligned: 12 Modelled: 12 Confidence: 10.8% Identity: 25% PDB header:ribosome Chain: S: PDB Molecule:40s ribosomal protein s23, putative; PDBTitle: high-resolution cryo-electron microscopy structure of the trypanosoma2 brucei ribosome Phyre2 PDB 2mv6 chain A Region: 16 - 53 Aligned: 31 Modelled: 38 Confidence: 10.3% Identity: 29% PDB header:membrane protein Chain: A: PDB Molecule:erythropoietin receptor; PDBTitle: solution structure of the transmembrane domain and the juxta-membrane2 domain of the erythropoietin receptor in micelles Phyre2 PDB 5xyi chain X Region: 24 - 35 Aligned: 12 Modelled: 12 Confidence: 8.7% Identity: 17% PDB header:ribosome Chain: X: PDB Molecule:40s ribosomal protein s23, putative; PDBTitle: small subunit of trichomonas vaginalis ribosome Phyre2 PDB 5jx6 chain C Region: 195 - 259 Aligned: 50 Modelled: 50 Confidence: 6.1% Identity: 20% PDB header:hydrolase Chain: C: PDB Molecule:glucanase; PDBTitle: gh6 orpinomyces sp. y102 enzyme Phyre2 PDB 3skq chain A Region: 188 - 219 Aligned: 32 Modelled: 32 Confidence: 5.9% Identity: 19% PDB header:metal transport Chain: A: PDB Molecule:mitochondrial distribution and morphology protein 38; PDBTitle: mdm38 is a 14-3-3-like receptor and associates with the protein2 synthesis machinery at the inner mitochondrial membrane Phyre2 PDB 2lsm chain A Region: 227 - 246 Aligned: 20 Modelled: 20 Confidence: 5.7% Identity: 20% PDB header:chaperone Chain: A: PDB Molecule:dna-packaging protein fi; PDBTitle: solution structure of gpfi c-terminal domain Phyre2 PDB 3ol0 chain C Region: 5 - 26 Aligned: 22 Modelled: 22 Confidence: 5.3% Identity: 27% PDB header:de novo protein Chain: C: PDB Molecule:de novo designed monomer trefoil-fold sub-domain which PDBTitle: crystal structure of monofoil-4p homo-trimer: de novo designed monomer2 trefoil-fold sub-domain which forms homo-trimer assembly Phyre2 1 c5d7tH_ 2 c4huqT_ 3 c4rfsT_ 4 c5x3xq_ 5 c3hd7A_ 6 c2xzmL_ 7 c1s1hL_ 8 c3u5gX_ 9 d1k4ta2 10 c3j20N_ 11 c2zkql_ 12 c3zeyS_ 13 c2mv6A_ 14 c5xyiX_ 15 c5jx6C_ 16 c3skqA_ 17 c2lsmA_ 18 c3ol0C_