1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	E	Q	H	T	L	L	Q	R	E	E	S	P	R	S	P	A	A	P	S	L	R	R	L	G	G	S	R	H	I	T	H	W	D	P	E	D	L	G	A	W	E	A	G	N	K	G	I	A	R	R	N	L	L	W	S	V	V	T	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?					?		?	?			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	L	G	Y	S	V	W	T	L	W	P	V	L	E	L	L	M	P	Q	D	V	Y	G	F	S	T	S	D	K	F	L	L	G	T	I	A	T	L	F	G	A	F	L	R	M	P	Y	A	L	A	S	A	I	F	G	G	R	N	W	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	F	S	A	I	V	L	L	I	P	A	I	G	T	T	V	L	L	T	H	P	G	L	P	L	W	P	Y	L	V	C	A	A	L	T	G	L	G	G	G	N	F	A	S	S	M	S	N	A	N	A	F	Y	P	H	R	L	K	G	S
Secondary structure
SS confidence
Disorder																			?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	L	G	I	A	G	G	V	G	N	L	G	V	P	A	I	Q	L	V	G	L	L	A	I	A	T	V	G	E	R	K	P	Y	L	V	C	A	L	Y	V	V	L	V	A	I	A	V	I	G	V	S	L	F	M	N	N	V	E	Q	H
Secondary structure
SS confidence
Disorder																																																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	V	Q	V	N	R	L	R	P	I	V	S	A	V	L	S	T	R	D	T	W	L	L	S	L	L	Y	L	G	T	F	G	S	F	I	G	F	S	F	V	F	G	Q	V	L	Q	T	N	F	L	A	C	G	Q	S	P	A	R	A	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																																										?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	H	A	V	E	L	A	F	V	G	P	L	L	A	A	V	A	R	I	Y	G	G	R	L	A	D	R	V	G	G	S	R	L	T	L	I	V	F	V	A	M	T	L	A	A	G	L	L	I	S	A	S	T	L	E	G	R	H	V	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		Q	H	R	G	A	T	M	V	G	Y	F	V	C	F	V	A	L	F	V	L	S	G	L	G	N	G	S	V	Y	K	M	I	P	T	I	F	E	A	C	S	R	S	L	D	L	S	E	A	E	R	R	D	W	S	R	I	I	S	G	V
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		V	I	G	F	V	A	A	F	G	A	L	G	G	V	G	I	N	M	A	L	R	E	S	Y	L	S	T	G	S	G	T	D	A	F	W	I	F	M	M	C	Y	A	A	A	A	V	L	T	W	K	V	Y	D	R	R	T	V	T	D	M
Secondary structure
SS confidence
Disorder																																																								?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.
Sequence		G	M	L	Q	A	A	L	V	R	Q	P	A	S	T	P	A	E	L	I	G	P	R	T	Q	S	D	R	F	S	G	C	S	I	S	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 76%) Beta strand ( 0%) TM helix ( 55%) (View membrane topology prediction)

Rank Aligned region

PDB 4iu8 chain A Region: 30 - 472 Aligned: 421 Modelled: 443 Confidence: 100.0% Identity: 33% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter (selenomethionine2 derivative) Phyre2 PDB 4iu9 chain A Region: 30 - 472 Aligned: 395 Modelled: 410 Confidence: 100.0% Identity: 35% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter Phyre2 PDB 1pw4 chain A Region: 23 - 485 Aligned: 429 Modelled: 438 Confidence: 100.0% Identity: 13% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 6e9o chain A Region: 44 - 477 Aligned: 392 Modelled: 399 Confidence: 100.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 3o7p chain A Region: 51 - 476 Aligned: 388 Modelled: 395 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 4lds chain B Region: 53 - 480 Aligned: 418 Modelled: 428 Confidence: 100.0% Identity: 12% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 4zp0 chain A Region: 46 - 474 Aligned: 389 Modelled: 403 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 3wdo chain A Region: 42 - 497 Aligned: 406 Modelled: 419 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 6g9x chain B Region: 50 - 477 Aligned: 367 Modelled: 378 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 6h7d chain A Region: 50 - 505 Aligned: 449 Modelled: 456 Confidence: 100.0% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:sugar transport protein 10; PDBTitle: crystal structure of a. thaliana sugar transport protein 10 in complex2 with glucose in the outward occluded state Phyre2 PDB 6gs7 chain A Region: 51 - 477 Aligned: 422 Modelled: 427 Confidence: 100.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:dipeptide and tripeptide permease a; PDBTitle: crystal structure of peptide transporter dtpa-nanobody in glycine2 buffer Phyre2 PDB 4cl5 chain B Region: 42 - 477 Aligned: 435 Modelled: 436 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:nitrate transporter 1.1; PDBTitle: crystal structure of the nitrate transporter nrt1.1 from2 arabidopsis thaliana in complex with nitrate. Phyre2 PDB 4ybq chain B Region: 42 - 492 Aligned: 447 Modelled: 451 Confidence: 100.0% Identity: 10% PDB header:transport protein/immune system Chain: B: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: rat glut5 with fv in the outward-open form Phyre2 PDB 6exs chain A Region: 42 - 477 Aligned: 429 Modelled: 436 Confidence: 100.0% Identity: 9% PDB header:membrane protein Chain: A: PDB Molecule:peptide abc transporter permease; PDBTitle: crystal structure of a pot family transporter in complex with2 thioalcohol conjugated peptide. Phyre2 PDB 5c65 chain A Region: 47 - 490 Aligned: 439 Modelled: 444 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: structure of the human glucose transporter glut3 / slc2a3 Phyre2 PDB 4iky chain A Region: 42 - 481 Aligned: 433 Modelled: 440 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:di-tripeptide abc transporter (permease); PDBTitle: crystal structure of peptide transporter pot (e310q mutant) in complex2 with sulfate Phyre2 PDB 4j05 chain A Region: 50 - 490 Aligned: 414 Modelled: 415 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 4aps chain B Region: 51 - 470 Aligned: 413 Modelled: 420 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: B: PDB Molecule:di-or tripeptide h+ symporter; PDBTitle: crystal structure of a pot family peptide transporter in an inward2 open conformation. Phyre2 PDB 4pyp chain A Region: 51 - 478 Aligned: 421 Modelled: 428 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: crystal structure of the human glucose transporter glut1 Phyre2 PDB 4w6v chain A Region: 42 - 477 Aligned: 433 Modelled: 435 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:di-/tripeptide transporter; PDBTitle: crystal structure of a peptide transporter from yersinia2 enterocolitica at 3 a resolution Phyre2 1 c4iu8A_ 2 c4iu9A_ 3 d1pw4a_ 4 c6e9oA_ 5 c3o7pA_ 6 c4ldsB_ 7 c4zp0A_ 8 c3wdoA_ 9 c6g9xB_ 10 c6h7dA_ 11 c6gs7A_ 12 c4cl5B_ 13 c4ybqB_ 14 c6exsA_ 15 c5c65A_ 16 c4ikyA_ 17 c4j05A_ 18 c4apsB_ 19 c4pypA_ 20 c4w6vA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68