1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	V	P	H	E	Q	P	A	L	S	S	S	K	S	N	R	F	T	S	Q	R	Q	T	T	G	V	G	T	T	T	V	E	R	L	E	P	R	L	S	P	A	S	R	H	I	T	E	A	K	A	F	G	T	E	C	H	V	S	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?				?	?	?						?	?	?	?	?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	T	R	E	Q	D	P	D	R	A	V	R	V	E	Q	I	H	G	E	A	Y	V	A	A	G	H	V	Y	E	S	A	L	D	E	L	G	R	L	D	N	S	N	A	E	F	I	L	D	K	A	R	G	S	T	R	E	T	E	V	I
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	L	H	A	V	P	A	E	P	L	S	G	S	Q	G	E	G	G	L	R	I	V	G	I	S	A	V	G	S	I	D	D	L	S	A	F	K	A	A	K	P	S	M	G	L	A	H	Q	R	K	L	Y	D	A	I	E	D	L	G	H
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?	?	?																				?	?	?		?	?	?	?	?	?	?	?	?												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	G	V	K	E	I	A	A	L	S	V	T	A	D	A	P	P	T	V	S	Y	S	L	I	R	E	V	L	R	L	Y	H	R	T	G	E	K	L	I	I	T	F	A	M	P	A	Y	A	K	M	V	M	N	F	G	R	F	A	M	P
Secondary structure
SS confidence
Disorder										?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	V	G	E	P	F	Y	A	H	R	N	N	D	P	R	T	S	N	D	L	L	L	V	P	S	I	V	E	P	S	N	F	L	E	N	I	S	R	G	V	V	T	A	D	D	G	P	T	A	R	R	R	F	A	T	L	C	Y	M	T
Secondary structure
SS confidence
Disorder													?		?	?	?	?	?																								?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.
Sequence		D	G	L	D	D	Y	F	M	P	L	T	R	Q	V	L	S	E	G	I	Q	D	I
Secondary structure
SS confidence
Disorder																			?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 30%) Alpha helix ( 51%) Beta strand ( 12%)

Rank Aligned region

PDB 2f5z chain K Region: 38 - 48 Aligned: 11 Modelled: 11 Confidence: 41.6% Identity: 73% PDB header:oxidoreductase/protein binding Chain: K: PDB Molecule:pyruvate dehydrogenase protein x component; PDBTitle: crystal structure of human dihydrolipoamide dehydrogenase2 (e3) complexed to the e3-binding domain of human e3-3 binding protein Phyre2 PDB 1zy8 chain M Region: 38 - 48 Aligned: 11 Modelled: 11 Confidence: 40.6% Identity: 73% PDB header:oxidoreductase Chain: M: PDB Molecule:pyruvate dehydrogenase protein x component, PDBTitle: the crystal structure of dihydrolipoamide dehydrogenase and2 dihydrolipoamide dehydrogenase-binding protein (didomain)3 subcomplex of human pyruvate dehydrogenase complex. Phyre2 PDB 2f60 chain K Region: 35 - 48 Aligned: 14 Modelled: 14 Confidence: 31.3% Identity: 64% PDB header:protein binding Chain: K: PDB Molecule:pyruvate dehydrogenase protein x component; PDBTitle: crystal structure of the dihydrolipoamide dehydrogenase (e3)-binding2 domain of human e3-binding protein Phyre2 PDB 5h0j chain A Region: 232 - 246 Aligned: 15 Modelled: 15 Confidence: 25.6% Identity: 47% PDB header:lyase Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of wt pedobacter heparinus smug2 Phyre2 PDB 3kwv chain F Region: 206 - 221 Aligned: 16 Modelled: 16 Confidence: 23.4% Identity: 38% PDB header:toxin/protein transport Chain: F: PDB Molecule:lethal factor; PDBTitle: structural basis for the unfolding of anthrax lethal factor by2 protective antigen oligomers Phyre2 PDB 3ah5 chain E Region: 170 - 215 Aligned: 41 Modelled: 46 Confidence: 21.6% Identity: 17% PDB header:transferase Chain: E: PDB Molecule:thymidylate synthase thyx; PDBTitle: crystal structure of flavin dependent thymidylate synthase thyx from2 helicobacter pylori complexed with fad and dump Phyre2 PDB 1j7n chain A domain 1 Region: 206 - 221 Aligned: 16 Modelled: 16 Confidence: 21.4% Identity: 38% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Anthrax toxin lethal factor, N- and C-terminal domains Phyre2 PDB 4pug chain A Region: 121 - 197 Aligned: 66 Modelled: 77 Confidence: 19.6% Identity: 20% PDB header:dna binding protein Chain: A: PDB Molecule:bola like protein; PDBTitle: bola1 from arabidopsis thaliana Phyre2 PDB 5x42 chain B Region: 304 - 316 Aligned: 13 Modelled: 13 Confidence: 17.7% Identity: 54% PDB header:protein transport Chain: B: PDB Molecule:icmo (dotl); PDBTitle: structure of dotl(590-659)-dotn derived from legionella pneumophila Phyre2 PDB 1oe4 chain A Region: 203 - 246 Aligned: 35 Modelled: 44 Confidence: 16.2% Identity: 31% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Single-strand selective monofunctional uracil-DNA glycosylase SMUG1 Phyre2 PDB 3o2e chain A Region: 165 - 196 Aligned: 28 Modelled: 32 Confidence: 16.0% Identity: 29% PDB header:unknown function Chain: A: PDB Molecule:bola-like protein; PDBTitle: crystal structure of a bol-like protein from babesia bovis Phyre2 PDB 5nfm chain A Region: 165 - 196 Aligned: 29 Modelled: 32 Confidence: 14.7% Identity: 24% PDB header:ligase Chain: A: PDB Molecule:yrba; PDBTitle: crystal structure of yrba from sinorhizobium meliloti in complex with2 copper. Phyre2 PDB 5h93 chain C Region: 232 - 246 Aligned: 15 Modelled: 15 Confidence: 14.3% Identity: 53% PDB header:hydrolase Chain: C: PDB Molecule:geobacter metallireducens smug1; PDBTitle: crystal structure of geobacter metallireducens smug1 Phyre2 PDB 2hac chain A Region: 296 - 303 Aligned: 8 Modelled: 8 Confidence: 14.1% Identity: 63% PDB header:membrane protein Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 zeta chain; PDBTitle: structure of zeta-zeta transmembrane dimer Phyre2 PDB 2hac chain B Region: 296 - 303 Aligned: 8 Modelled: 8 Confidence: 14.1% Identity: 63% PDB header:membrane protein Chain: B: PDB Molecule:t-cell surface glycoprotein cd3 zeta chain; PDBTitle: structure of zeta-zeta transmembrane dimer Phyre2 PDB 5w6y chain B Region: 304 - 314 Aligned: 11 Modelled: 11 Confidence: 14.0% Identity: 64% PDB header:biosynthetic protein,isomerase Chain: B: PDB Molecule:chorismate mutase; PDBTitle: physcomitrella patens chorismate mutase Phyre2 PDB 2q2k chain B Region: 271 - 291 Aligned: 21 Modelled: 21 Confidence: 13.9% Identity: 48% PDB header:dna binding protein/dna Chain: B: PDB Molecule:hypothetical protein; PDBTitle: structure of nucleic-acid binding protein Phyre2 PDB 2q2k chain A Region: 271 - 291 Aligned: 21 Modelled: 21 Confidence: 12.8% Identity: 48% PDB header:dna binding protein/dna Chain: A: PDB Molecule:hypothetical protein; PDBTitle: structure of nucleic-acid binding protein Phyre2 PDB 6h3p chain B Region: 304 - 314 Aligned: 11 Modelled: 11 Confidence: 12.1% Identity: 55% PDB header:plant protein Chain: B: PDB Molecule:chorismate mutase; PDBTitle: crystal structure of the cytoplasmic chorismate mutase from zea mays Phyre2 PDB 5csm chain A Region: 304 - 314 Aligned: 11 Modelled: 11 Confidence: 12.1% Identity: 27% Fold: Chorismate mutase II Superfamily: Chorismate mutase II Family: Allosteric chorismate mutase Phyre2 1 c2f5zK_ 2 c1zy8M_ 3 c2f60K_ 4 c5h0jA_ 5 c3kwvF_ 6 c3ah5E_ 7 d1j7na1 8 c4pugA_ 9 c5x42B_ 10 d1oe4a_ 11 c3o2eA_ 12 c5nfmA_ 13 c5h93C_ 14 c2hacA_ 15 c2hacB_ 16 c5w6yB_ 17 c2q2kB_ 18 c2q2kA_ 19 c6h3pB_ 20 d5csma_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54