1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	A	S	E	H	D	P	Y	D	D	F	D	R	Q	R	R	V	A	E	A	P	K	T	A	G	L	P	G	T	E	G	Q	Y	R	S	D	F	A	R	D	R	A	R	V	L	H	S	A	A	L	R	R	L	A	D	K	T	Q	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	G	P	R	E	G	D	T	P	R	T	R	L	T	H	S	L	E	V	A	Q	I	G	R	G	M	A	I	G	L	G	C	D	L	D	L	V	E	L	A	G	L	A	H	D	I	G	H	P	P	Y	G	H	N	G	E	R	A	L	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	V	A	A	S	H	G	G	F	E	G	N	A	Q	N	F	R	I	L	T	S	L	E	P	K	V	V	D	A	Q	G	L	S	A	G	L	N	L	T	R	A	S	L	D	A	V	T	K	Y	P	W	M	R	G	D	G	L	G	S	Q
Secondary structure
SS confidence
Disorder								?	?		?																		?	?	?	?	?																				?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	R	K	F	G	F	Y	D	D	D	R	E	S	A	V	W	V	R	Q	G	A	P	P	E	R	A	C	L	E	A	Q	V	M	D	W	A	D	D	V	A	Y	S	V	H	D	V	E	D	G	V	V	S	E	R	I	D	L	R	V	L
Secondary structure
SS confidence
Disorder																						?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	A	E	E	D	A	A	A	L	A	R	L	G	E	R	E	F	S	R	V	S	A	D	E	L	M	A	A	A	R	R	L	S	R	L	P	V	V	A	A	V	G	K	Y	D	A	T	L	S	A	S	V	A	L	K	R	L	T	S	E
Secondary structure
SS confidence
Disorder																?																												?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	V	G	R	F	A	S	A	A	I	A	T	T	R	A	A	A	G	P	G	P	L	V	R	F	R	A	D	L	Q	V	P	D	L	V	R	A	E	V	A	V	L	K	I	L	A	L	Q	F	I	M	S	D	P	R	H	L	E	T	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	R	Q	R	E	R	I	H	R	V	A	H	R	L	Y	S	G	A	P	Q	T	L	D	P	V	Y	A	A	A	F	N	T	A	A	D	D	A	A	R	L	R	V	V	V	D	Q	I	A	S	Y	T	E	G	R	L	E	R	I	D	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.
Sequence		D	Q	L	G	V	S	R	N	A	L	D
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 65%) Beta strand ( 0%)

Rank Aligned region

PDB 4xds chain E Region: 18 - 427 Aligned: 385 Modelled: 396 Confidence: 100.0% Identity: 25% PDB header:hydrolase/dna Chain: E: PDB Molecule:deoxyguanosinetriphosphate triphosphohydrolase; PDBTitle: deoxyguanosinetriphosphate triphosphohydrolase from escherichia coli2 with nickel Phyre2 PDB 3bg2 chain A Region: 21 - 425 Aligned: 341 Modelled: 359 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:dgtp triphosphohydrolase; PDBTitle: crystal structure of deoxyguanosinetriphosphate triphosphohydrolase2 from flavobacterium sp. med217 Phyre2 PDB 2pgs chain A Region: 32 - 421 Aligned: 331 Modelled: 349 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyguanosinetriphosphate triphosphohydrolase; PDBTitle: crystal structure of a putative deoxyguanosinetriphosphate2 triphosphohydrolase from pseudomonas syringae pv. phaseolicola 1448a Phyre2 PDB 2dqb chain B Region: 7 - 423 Aligned: 333 Modelled: 351 Confidence: 100.0% Identity: 34% PDB header:hydrolase, dna binding protein Chain: B: PDB Molecule:deoxyguanosinetriphosphate triphosphohydrolase, putative; PDBTitle: crystal structure of dntp triphosphohydrolase from thermus2 thermophilus hb8, which is homologous to dgtp triphosphohydrolase Phyre2 PDB 2hek chain A domain 1 Region: 44 - 233 Aligned: 189 Modelled: 190 Confidence: 100.0% Identity: 17% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 5ao4 chain D Region: 37 - 369 Aligned: 238 Modelled: 249 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: D: PDB Molecule:deoxynucleoside triphosphate triphosphohydrolase samhd1; PDBTitle: crystal structure of in vitro phosphorylated human samhd1 (amino acid2 residues 115-626) bound to gtp Phyre2 PDB 2q14 chain A Region: 44 - 424 Aligned: 255 Modelled: 275 Confidence: 99.7% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:phosphohydrolase; PDBTitle: crystal structure of phosphohydrolase (bt4208) from bacteroides2 thetaiotaomicron vpi-5482 at 2.20 a resolution Phyre2 PDB 2o6i chain A domain 1 Region: 44 - 143 Aligned: 88 Modelled: 96 Confidence: 99.7% Identity: 33% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 2o6i chain A Region: 44 - 143 Aligned: 88 Modelled: 96 Confidence: 99.7% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:hd domain protein; PDBTitle: structure of an enterococcus faecalis hd domain phosphohydrolase Phyre2 PDB 3u1n chain C Region: 44 - 142 Aligned: 98 Modelled: 99 Confidence: 99.7% Identity: 26% PDB header:hydrolase Chain: C: PDB Molecule:sam domain and hd domain-containing protein 1; PDBTitle: structure of the catalytic core of human samhd1 Phyre2 PDB 4bzb chain B Region: 44 - 142 Aligned: 95 Modelled: 99 Confidence: 99.7% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:deoxynucleoside triphosphate triphosphohydrolase samhd1; PDBTitle: crystal structure of the tetrameric dgtp-bound samhd12 mutant catalytic core Phyre2 PDB 6brh chain A Region: 44 - 142 Aligned: 95 Modelled: 99 Confidence: 99.5% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:deoxynucleoside triphosphate triphosphohydrolase samhd1; PDBTitle: the sam domain of mouse samhd1 is critical for its activation and2 regulation Phyre2 PDB 4s1c chain A Region: 74 - 229 Aligned: 144 Modelled: 156 Confidence: 99.2% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:lmo1466 protein; PDBTitle: crystal structure of l. monocytogenes phosphodiesterase pgph hd domain Phyre2 PDB 5ihy chain B Region: 75 - 219 Aligned: 95 Modelled: 95 Confidence: 98.6% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of bacillus subtilis semet-ypgq Phyre2 PDB 3gw7 chain A Region: 67 - 217 Aligned: 99 Modelled: 99 Confidence: 98.6% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein yedj; PDBTitle: crystal structure of a metal-dependent phosphohydrolase with conserved2 hd domain (yedj) from escherichia coli in complex with nickel ions.3 northeast structural genomics consortium target er63 Phyre2 PDB 2o08 chain B Region: 72 - 231 Aligned: 112 Modelled: 129 Confidence: 98.4% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:bh1327 protein; PDBTitle: crystal structure of a putative hd superfamily hydrolase (bh1327) from2 bacillus halodurans at 1.90 a resolution Phyre2 PDB 2pq7 chain A domain 1 Region: 63 - 224 Aligned: 110 Modelled: 129 Confidence: 98.3% Identity: 19% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 3ccg chain A Region: 72 - 231 Aligned: 114 Modelled: 129 Confidence: 98.3% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:hd superfamily hydrolase; PDBTitle: crystal structure of predicted hd superfamily hydrolase involved in2 nad metabolism (np_347894.1) from clostridium acetobutylicum at 1.503 a resolution Phyre2 PDB 2qgs chain A domain 1 Region: 65 - 219 Aligned: 97 Modelled: 97 Confidence: 98.3% Identity: 18% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 2ogi chain A Region: 72 - 107 Aligned: 36 Modelled: 36 Confidence: 98.1% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:hypothetical protein sag1661; PDBTitle: crystal structure of a putative metal dependent phosphohydrolase2 (sag1661) from streptococcus agalactiae serogroup v at 1.85 a3 resolution Phyre2 1 c4xdsE_ 2 c3bg2A_ 3 c2pgsA_ 4 c2dqbB_ 5 d2heka1 6 c5ao4D_ 7 c2q14A_ 8 d2o6ia1 9 c2o6iA_ 10 c3u1nC_ 11 c4bzbB_ 12 c6brhA_ 13 c4s1cA_ 14 c5ihyB_ 15 c3gw7A_ 16 c2o08B_ 17 d2pq7a1 18 c3ccgA_ 19 d2qgsa1 20 c2ogiA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127