1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	R	R	Q	F	F	A	K	A	A	A	A	T	T	A	G	A	F	M	S	L	A	G	P	I	I	E	K	A	Y	G	A	G	P	C	P	G	H	L	T	D	I	E	H	I	V	L	L	M	Q	E	N	R	S	F	D	H	Y	F
Secondary structure
SS confidence
Disorder		?	?																				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	T	L	S	D	T	R	G	F	D	D	T	T	P	P	V	V	F	A	Q	S	G	W	N	P	M	T	Q	A	V	D	P	A	G	V	T	L	P	Y	R	F	D	T	T	R	G	P	L	V	A	G	E	C	V	N	D	P	D	H	S
Secondary structure
SS confidence
Disorder													?		?	?	?	?	?	?	?					?																				?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		W	I	G	M	H	N	S	W	N	G	G	A	N	D	N	W	L	P	A	Q	V	P	F	S	P	L	Q	G	N	V	P	V	T	M	G	F	Y	T	R	R	D	L	P	I	H	Y	L	L	A	D	T	F	T	V	C	D	G	Y	F	C
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	L	L	G	G	T	T	P	N	R	L	Y	W	M	S	A	W	I	D	P	D	G	T	D	G	G	P	V	L	I	E	P	N	I	Q	P	L	Q	H	Y	S	W	R	I	M	P	E	N	L	E	D	A	G	V	S	W	K	V	Y	Q
Secondary structure
SS confidence
Disorder		?																	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	K	L	L	G	A	L	N	N	T	V	V	G	Y	N	G	L	V	N	D	F	K	Q	A	A	D	P	R	S	N	L	A	R	F	G	I	S	P	T	Y	P	L	D	F	A	A	D	V	R	N	N	R	L	P	K	V	S	W	V	L
Secondary structure
SS confidence
Disorder																													?	?	?		?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		P	G	F	L	L	S	E	H	P	A	F	P	V	N	V	G	A	V	A	I	V	D	A	L	R	I	L	L	S	N	P	A	V	W	E	K	T	A	L	I	V	N	Y	D	E	N	G	G	F	F	D	H	V	V	P	P	T	P	P	P
Secondary structure
SS confidence
Disorder																																																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	T	P	G	E	F	V	T	V	P	D	I	D	S	V	P	G	S	G	G	I	R	G	P	I	G	L	G	F	R	V	P	C	L	V	I	S	P	Y	S	R	G	P	L	M	V	H	D	T	F	D	H	T	S	T	L	K	L	I	R
Secondary structure
SS confidence
Disorder		?		?	?	?							?	?	?	?	?	?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	R	F	G	V	P	V	P	N	L	T	A	W	R	D	A	T	V	G	D	M	T	S	T	F	N	F	A	A	P	P	N	P	S	K	P	N	L	D	H	P	R	L	N	A	L	P	K	L	P	Q	C	V	P	N	A	V	L	G	T
Secondary structure
SS confidence
Disorder									?	?	?		?	?	?	?																	?	?	?	?	?	?	?	?	?	?	?	?	?	?								?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.
Sequence		V	T	K	T	A	I	P	Y	R	V	P	F	P	Q	S	M	P	T	Q	E	T	A	P	T	R	G	I	P	S	G	L	C
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 26%) Alpha helix ( 23%) Beta strand ( 6%)

Rank Aligned region

PDB 2d1g chain B Region: 23 - 466 Aligned: 407 Modelled: 426 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:acid phosphatase; PDBTitle: structure of francisella tularensis acid phosphatase a (acpa) bound to2 orthovanadate Phyre2 PDB 6hr5 chain A Region: 157 - 429 Aligned: 241 Modelled: 249 Confidence: 99.4% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:alpha-l-rhamnosidase/sulfatase (gh78); PDBTitle: structure of the s1_25 family sulfatase module of the rhamnosidase2 fa22250 from formosa agariphila Phyre2 PDB 1auk chain A Region: 154 - 429 Aligned: 256 Modelled: 260 Confidence: 99.4% Identity: 18% Fold: Alkaline phosphatase-like Superfamily: Alkaline phosphatase-like Family: Arylsulfatase Phyre2 PDB 6b1v chain B Region: 154 - 428 Aligned: 253 Modelled: 256 Confidence: 99.4% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:iota-carrageenan sulfatase; PDBTitle: crystal structure of ps i-cgsb c78s in complex with i-neocarratetraose Phyre2 PDB 6j66 chain B Region: 154 - 428 Aligned: 248 Modelled: 251 Confidence: 99.3% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:chondroitin sulfate/dermatan sulfate 4-o-endosulfatase PDBTitle: chondroitin sulfate/dermatan sulfate endolytic 4-o-sulfatase Phyre2 PDB 4fdi chain A Region: 154 - 429 Aligned: 258 Modelled: 261 Confidence: 99.3% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:n-acetylgalactosamine-6-sulfatase; PDBTitle: the molecular basis of mucopolysaccharidosis iv a Phyre2 PDB 3lxq chain B Region: 156 - 429 Aligned: 235 Modelled: 245 Confidence: 99.2% Identity: 10% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein vp1736; PDBTitle: the crystal structure of a protein in the alkaline phosphatase2 superfamily from vibrio parahaemolyticus to 1.95a Phyre2 PDB 5g2v chain A Region: 154 - 429 Aligned: 243 Modelled: 252 Confidence: 99.2% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:n-acetylglucosamine-6-sulfatase; PDBTitle: structure of bt4656 in complex with its substrate d-glucosamine-2-n,2 6-o-disulfate. Phyre2 PDB 1fsu chain A Region: 154 - 428 Aligned: 251 Modelled: 256 Confidence: 99.1% Identity: 19% Fold: Alkaline phosphatase-like Superfamily: Alkaline phosphatase-like Family: Arylsulfatase Phyre2 PDB 4miv chain B Region: 156 - 428 Aligned: 233 Modelled: 236 Confidence: 99.1% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:n-sulphoglucosamine sulphohydrolase; PDBTitle: crystal structure of sulfamidase, crystal form l Phyre2 PDB 3ed4 chain A Region: 154 - 428 Aligned: 261 Modelled: 275 Confidence: 99.1% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:arylsulfatase; PDBTitle: crystal structure of putative arylsulfatase from escherichia coli Phyre2 PDB 5fql chain A Region: 154 - 429 Aligned: 242 Modelled: 252 Confidence: 99.1% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:iduronate-2-sulfatase; PDBTitle: insights into hunter syndrome from the structure of iduronate-2-2 sulfatase Phyre2 PDB 1p49 chain A Region: 154 - 428 Aligned: 261 Modelled: 275 Confidence: 99.1% Identity: 17% Fold: Alkaline phosphatase-like Superfamily: Alkaline phosphatase-like Family: Arylsulfatase Phyre2 PDB 4upk chain C Region: 156 - 429 Aligned: 241 Modelled: 250 Confidence: 99.1% Identity: 16% PDB header:hydrolase Chain: C: PDB Molecule:phosphonate monoester hydrolase; PDBTitle: phosphonate monoester hydrolase sppmh from silicibacter pomeroyi Phyre2 PDB 6hhm chain A Region: 157 - 430 Aligned: 241 Modelled: 250 Confidence: 99.1% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:arylsulfatase; PDBTitle: crystal structure of the family s1_7 ulvan-specific sulfatase fa220702 from formosa agariphila Phyre2 PDB 4ug4 chain H Region: 148 - 428 Aligned: 247 Modelled: 257 Confidence: 99.0% Identity: 15% PDB header:hydrolase Chain: H: PDB Molecule:choline sulfatase; PDBTitle: crystal structure of a choline sulfatase from sinorhizobium2 melliloti Phyre2 PDB 2vqr chain A Region: 153 - 429 Aligned: 244 Modelled: 253 Confidence: 99.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:putative sulfatase; PDBTitle: crystal structure of a phosphonate monoester hydrolase from rhizobium2 leguminosarum: a new member of the alkaline phosphatase superfamily Phyre2 PDB 4uop chain B Region: 156 - 429 Aligned: 251 Modelled: 260 Confidence: 99.0% Identity: 13% PDB header:transferase Chain: B: PDB Molecule:lipoteichoic acid primase; PDBTitle: crystal structure of the lipoteichoic acid synthase ltap from listeria2 monocytogenes Phyre2 PDB 4upl chain C Region: 154 - 428 Aligned: 242 Modelled: 251 Confidence: 99.0% Identity: 14% PDB header:hydrolase Chain: C: PDB Molecule:sulfatase family protein; PDBTitle: dimeric sulfatase spas2 from silicibacter pomeroyi Phyre2 PDB 2w8d chain B Region: 156 - 429 Aligned: 249 Modelled: 259 Confidence: 99.0% Identity: 12% PDB header:transferase Chain: B: PDB Molecule:processed glycerol phosphate lipoteichoic acid synthase 2; PDBTitle: distinct and essential morphogenic functions for wall- and2 lipo-teichoic acids in bacillus subtilis Phyre2 1 c2d1gB_ 2 c6hr5A_ 3 d1auka_ 4 c6b1vB_ 5 c6j66B_ 6 c4fdiA_ 7 c3lxqB_ 8 c5g2vA_ 9 d1fsua_ 10 c4mivB_ 11 c3ed4A_ 12 c5fqlA_ 13 d1p49a_ 14 c4upkC_ 15 c6hhmA_ 16 c4ug4H_ 17 c2vqrA_ 18 c4uopB_ 19 c4uplC_ 20 c2w8dB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99