1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	P	S	L	P	D	R	L	A	S	I	L	R	D	V	L	P	A	E	E	E	P	D	G	A	L	T	V	R	H	D	G	T	F	A	S	L	R	V	V	S	I	A	E	D	L	E	L	V	S	L	T	Q	I	L	A	W	D	L	P
Secondary structure
SS confidence
Disorder		?	?	?															?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	T	K	R	L	A	E	Q	V	A	K	Q	A	R	D	I	N	F	G	S	V	S	L	R	E	K	V	S	E	K	A	A	R	R	S	S	G	R	P	A	S	N	T	A	D	V	M	L	R	Y	N	F	P	G	T	G	L	T	D	D
Secondary structure
SS confidence
Disorder													?	?	?										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.
Sequence		A	L	R	T	L	I	L	L	V	L	E	T	G	A	T	I	R	S	A	L	V	G
Secondary structure
SS confidence
Disorder												?	?								?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 30%) Beta strand ( 30%)

Rank Aligned region

PDB 3ear chain A Region: 28 - 75 Aligned: 48 Modelled: 48 Confidence: 48.9% Identity: 10% PDB header:hydrolase Chain: A: PDB Molecule:hera; PDBTitle: novel dimerization motif in the dead box rna helicase hera: form 1,2 partial dimer Phyre2 PDB 2fzl chain A Region: 28 - 116 Aligned: 65 Modelled: 65 Confidence: 47.2% Identity: 14% PDB header:dna binding protein Chain: A: PDB Molecule:dna repair protein rad25, xpb; PDBTitle: structure of c-terminal domain of archaeoglobus fulgidus xpb Phyre2 PDB 5jcf chain B Region: 28 - 86 Aligned: 59 Modelled: 59 Confidence: 45.6% Identity: 12% PDB header:immune system Chain: B: PDB Molecule:melanoma differentiation associated protein-5; PDBTitle: crystal structure of chicken mda5 with 5'p 10-mer dsrna and adp-mg2+2 at 2.6 a resolution (orthorhombic form). Phyre2 PDB 5zam chain A Region: 42 - 86 Aligned: 45 Modelled: 45 Confidence: 45.5% Identity: 20% PDB header:hydrolase/protein binding/rna Chain: A: PDB Molecule:endoribonuclease dicer; PDBTitle: cryo-em structure of human dicer and its complexes with a pre-mirna2 substrate Phyre2 PDB 2plg chain A domain 1 Region: 5 - 141 Aligned: 119 Modelled: 119 Confidence: 42.6% Identity: 13% Fold: Secretion chaperone-like Superfamily: Type III secretory system chaperone-like Family: Tll0839-like Phyre2 PDB 5jb2 chain A Region: 28 - 86 Aligned: 59 Modelled: 59 Confidence: 40.4% Identity: 15% PDB header:immune system Chain: A: PDB Molecule:lgp2; PDBTitle: crystal structure of chicken lgp2 with 5'ppp 10-mer dsrna and adp-2 alf4-mg2+ at 2.2 a resolution. Phyre2 PDB 4gl2 chain A Region: 42 - 86 Aligned: 45 Modelled: 45 Confidence: 40.0% Identity: 16% PDB header:rna binding protein/rna Chain: A: PDB Molecule:interferon-induced helicase c domain-containing protein 1; PDBTitle: structural basis for dsrna duplex backbone recognition by mda5 Phyre2 PDB 2d7d chain A Region: 28 - 84 Aligned: 57 Modelled: 57 Confidence: 38.9% Identity: 18% PDB header:hydrolase/dna Chain: A: PDB Molecule:uvrabc system protein b; PDBTitle: structural insights into the cryptic dna dependent atp-ase2 activity of uvrb Phyre2 PDB 2p6n chain A Region: 31 - 75 Aligned: 45 Modelled: 45 Confidence: 34.9% Identity: 7% PDB header:hydrolase Chain: A: PDB Molecule:atp-dependent rna helicase ddx41; PDBTitle: human dead-box rna helicase ddx41, helicase domain Phyre2 PDB 2fwr chain A domain 1 Region: 28 - 90 Aligned: 63 Modelled: 63 Confidence: 30.9% Identity: 14% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Tandem AAA-ATPase domain Phyre2 PDB 1s2m chain A domain 2 Region: 31 - 76 Aligned: 46 Modelled: 46 Confidence: 28.3% Identity: 7% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Tandem AAA-ATPase domain Phyre2 PDB 1t5l chain A domain 2 Region: 28 - 84 Aligned: 57 Modelled: 57 Confidence: 24.9% Identity: 18% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Tandem AAA-ATPase domain Phyre2 PDB 2i4i chain A Region: 42 - 75 Aligned: 34 Modelled: 34 Confidence: 24.5% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:atp-dependent rna helicase ddx3x; PDBTitle: crystal structure of human dead-box rna helicase ddx3x Phyre2 PDB 1wp9 chain D Region: 28 - 84 Aligned: 57 Modelled: 57 Confidence: 24.5% Identity: 9% PDB header:hydrolase Chain: D: PDB Molecule:atp-dependent rna helicase, putative; PDBTitle: crystal structure of pyrococcus furiosus hef helicase domain Phyre2 PDB 2v1x chain B Region: 28 - 75 Aligned: 48 Modelled: 48 Confidence: 24.5% Identity: 6% PDB header:hydrolase Chain: B: PDB Molecule:atp-dependent dna helicase q1; PDBTitle: crystal structure of human recq-like dna helicase Phyre2 PDB 4kbf chain A Region: 42 - 75 Aligned: 34 Modelled: 34 Confidence: 24.3% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:heat resistant rna dependent atpase; PDBTitle: two different open conformations of the helicase core of the rna2 helicase hera Phyre2 PDB 1oyw chain A domain 3 Region: 28 - 84 Aligned: 57 Modelled: 55 Confidence: 23.7% Identity: 11% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Tandem AAA-ATPase domain Phyre2 PDB 3i32 chain A Region: 28 - 75 Aligned: 48 Modelled: 48 Confidence: 23.3% Identity: 8% PDB header:rna binding protein,hydrolase Chain: A: PDB Molecule:heat resistant rna dependent atpase; PDBTitle: dimeric structure of a hera helicase fragment including the c-terminal2 reca domain, the dimerization domain, and the rna binding domain Phyre2 PDB 4ljy chain A Region: 42 - 84 Aligned: 43 Modelled: 43 Confidence: 22.9% Identity: 7% PDB header:hydrolase Chain: A: PDB Molecule:pre-mrna-processing atp-dependent rna helicase prp5; PDBTitle: crystal structure of rna splicing effector prp5 in complex with adp Phyre2 PDB 4w7s chain A Region: 28 - 75 Aligned: 48 Modelled: 48 Confidence: 22.1% Identity: 6% PDB header:hydrolase Chain: A: PDB Molecule:pre-mrna-splicing atp-dependent rna helicase prp28; PDBTitle: crystal structure of the yeast dead-box splicing factor prp28 at 2.542 angstroms resolution Phyre2 1 c3earA_ 2 c2fzlA_ 3 c5jcfB_ 4 c5zamA_ 5 d2plga1 6 c5jb2A_ 7 c4gl2A_ 8 c2d7dA_ 9 c2p6nA_ 10 d2fwra1 11 d1s2ma2 12 d1t5la2 13 c2i4iA_ 14 c1wp9D_ 15 c2v1xB_ 16 c4kbfA_ 17 d1oywa3 18 c3i32A_ 19 c4ljyA_ 20 c4w7sA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90