1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	A	M	L	F	Y	V	D	T	L	P	D	T	G	A	V	A	V	V	D	G	D	E	G	F	H	A	A	T	V	R	R	I	R	P	G	E	Q	L	V	L	G	D	G	V	G	R	L	A	R	C	V	V	E	Q	A	G	R	G
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	L	R	A	R	V	L	R	R	W	S	V	P	P	V	R	P	P	V	T	V	V	Q	A	L	P	K	S	E	R	S	E	L	A	I	E	L	A	T	E	A	G	A	D	A	F	L	A	W	Q	A	A	R	C	V	A	N	W	D	G
Secondary structure
SS confidence
Disorder																																																								?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	R	V	D	K	G	L	R	R	W	R	A	V	V	R	S	A	A	R	Q	S	R	R	A	R	I	P	P	V	D	G	V	L	S	T	P	M	L	V	Q	R	V	R	E	E	V	A	A	G	A	A	V	L	V	L	H	E	E	A	T
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	R	I	V	D	I	A	A	A	Q	A	G	S	L	M	L	V	V	G	P	E	G	G	I	A	P	D	E	L	A	A	L	T	D	A	G	A	V	A	V	R	L	G	P	T	V	L	R	T	S	T	A	A	A	V	A	L	G	A	V
Secondary structure
SS confidence
Disorder				?			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.
Sequence		G	V	L	T	S	R	W	D	A	S	A	S	D	C	E	Y	C	D	V	T	R	R
Secondary structure
SS confidence
Disorder						?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 35%) Beta strand ( 27%)

Rank Aligned region

PDB 4l69 chain A Region: 2 - 248 Aligned: 244 Modelled: 244 Confidence: 100.0% Identity: 96% PDB header:transferase Chain: A: PDB Molecule:ribosomal rna small subunit methyltransferase e; PDBTitle: rv2372c of mycobacterium tuberculosis is rsme like methyltransferse Phyre2 PDB 5o96 chain F Region: 1 - 247 Aligned: 241 Modelled: 241 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: F: PDB Molecule:ribosomal rna small subunit methyltransferase e; PDBTitle: structure of the putative methyltransferase lpg2936 from legionella2 pneumophila in complex with the bound cofactor sam Phyre2 PDB 5vm8 chain A Region: 4 - 247 Aligned: 238 Modelled: 238 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:ribosomal rna small subunit methyltransferase e; PDBTitle: crystal structure of a ribosomal rna small subunit methyltransferase e2 from neisseria gonorrhoeae bound to s-adenosyl methionine Phyre2 PDB 4e8b chain A Region: 4 - 248 Aligned: 239 Modelled: 239 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:ribosomal rna small subunit methyltransferase e; PDBTitle: crystal structure of 16s rrna methyltransferase rsme from e.coli Phyre2 PDB 1vhy chain B Region: 4 - 249 Aligned: 234 Modelled: 230 Confidence: 100.0% Identity: 25% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein hi0303; PDBTitle: crystal structure of haemophilus influenzae protein hi0303, pfam2 duf558 Phyre2 PDB 4j3c chain B Region: 3 - 247 Aligned: 232 Modelled: 244 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: B: PDB Molecule:ribosomal rna small subunit methyltransferase e; PDBTitle: crystal structure of 16s ribosomal rna methyltransferase rsme Phyre2 PDB 1vhk chain A Region: 4 - 247 Aligned: 230 Modelled: 244 Confidence: 100.0% Identity: 32% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein yqeu; PDBTitle: crystal structure of an hypothetical protein Phyre2 PDB 3kw2 chain A Region: 4 - 250 Aligned: 234 Modelled: 230 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:probable r-rna methyltransferase; PDBTitle: crystal structure of probable rrna-methyltransferase from2 porphyromonas gingivalis Phyre2 PDB 2cx8 chain A Region: 12 - 246 Aligned: 222 Modelled: 221 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:methyl transferase; PDBTitle: crystal structure of methyltransferase with ligand(sah) Phyre2 PDB 2egw chain B Region: 4 - 242 Aligned: 226 Modelled: 226 Confidence: 100.0% Identity: 23% PDB header:rna methyltransferase Chain: B: PDB Molecule:upf0088 protein aq_165; PDBTitle: crystal structure of rrna methyltransferase with sah ligand Phyre2 PDB 1z85 chain B Region: 4 - 247 Aligned: 215 Modelled: 214 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: B: PDB Molecule:hypothetical protein tm1380; PDBTitle: crystal structure of a predicted rna methyltransferase (tm1380) from2 thermotoga maritima msb8 at 2.12 a resolution Phyre2 PDB 1nxz chain A domain 2 Region: 74 - 251 Aligned: 173 Modelled: 170 Confidence: 100.0% Identity: 28% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: YggJ C-terminal domain-like Phyre2 PDB 2cx8 chain B Region: 66 - 246 Aligned: 169 Modelled: 181 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: B: PDB Molecule:methyl transferase; PDBTitle: crystal structure of methyltransferase with ligand(sah) Phyre2 PDB 1vhk chain A domain 2 Region: 72 - 247 Aligned: 162 Modelled: 176 Confidence: 100.0% Identity: 38% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: YggJ C-terminal domain-like Phyre2 PDB 1v6z chain A domain 2 Region: 74 - 246 Aligned: 161 Modelled: 160 Confidence: 100.0% Identity: 36% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: YggJ C-terminal domain-like Phyre2 PDB 1nxz chain A domain 1 Region: 3 - 73 Aligned: 71 Modelled: 71 Confidence: 99.5% Identity: 21% Fold: PUA domain-like Superfamily: PUA domain-like Family: YggJ N-terminal domain-like Phyre2 PDB 1vhk chain A domain 1 Region: 4 - 71 Aligned: 68 Modelled: 68 Confidence: 99.4% Identity: 16% Fold: PUA domain-like Superfamily: PUA domain-like Family: YggJ N-terminal domain-like Phyre2 PDB 3ai9 chain X Region: 153 - 240 Aligned: 81 Modelled: 79 Confidence: 96.1% Identity: 21% PDB header:transferase Chain: X: PDB Molecule:upf0217 protein mj1640; PDBTitle: crystal structure of duf358 protein reveals a putative spout-class2 rrna methyltransferase Phyre2 PDB 2qmm chain A domain 1 Region: 153 - 240 Aligned: 81 Modelled: 81 Confidence: 95.7% Identity: 17% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: AF1056-like Phyre2 PDB 1v6z chain A domain 1 Region: 20 - 71 Aligned: 51 Modelled: 52 Confidence: 95.6% Identity: 25% Fold: PUA domain-like Superfamily: PUA domain-like Family: YggJ N-terminal domain-like Phyre2 1 c4l69A_ 2 c5o96F_ 3 c5vm8A_ 4 c4e8bA_ 5 c1vhyB_ 6 c4j3cB_ 7 c1vhkA_ 8 c3kw2A_ 9 c2cx8A_ 10 c2egwB_ 11 c1z85B_ 12 d1nxza2 13 c2cx8B_ 14 d1vhka2 15 d1v6za2 16 d1nxza1 17 d1vhka1 18 c3ai9X_ 19 d2qmma1 20 d1v6za1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139