1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	E	L	S	V	A	T	G	A	V	S	T	A	S	S	S	I	P	M	P	A	G	V	N	P	A	D	L	A	A	E	L	A	A	V	V	T	E	S	V	D	E	D	Y	L	L	Y	E	C	D	G	Q	W	V	L	A	A	G	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?																?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	A	M	V	E	L	D	S	D	E	L	R	V	I	R	D	G	V	T	R	R	Q	Q	W	S	G	R	P	G	A	A	L	G	E	A	V	D	R	L	L	L	E	T	D	Q	A	F	G	W	V	A	F	E	F	G	V	H	R	Y	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	Q	Q	R	L	A	P	H	T	P	L	A	R	V	F	S	P	R	T	R	I	M	V	S	E	K	E	I	R	L	F	D	A	G	I	R	H	R	E	A	I	D	R	L	L	A	T	G	V	R	E	V	P	Q	S	R	S	V	D	V
Secondary structure
SS confidence
Disorder				?	?																																										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	D	D	P	S	G	F	R	R	R	V	A	V	A	V	D	E	I	A	A	G	R	Y	H	K	V	I	L	S	R	C	V	E	V	P	F	A	I	D	F	P	L	T	Y	R	L	G	R	R	H	N	T	P	V	R	S	F	L	L	Q
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	G	G	I	R	A	L	G	Y	S	P	E	L	V	T	A	V	R	A	D	G	V	V	I	T	E	P	L	A	G	T	R	A	L	G	R	G	P	A	I	D	R	L	A	R	D	D	L	E	S	N	S	K	E	I	V	E	H	A	I
Secondary structure
SS confidence
Disorder																																					?													?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	V	R	S	S	L	E	E	I	T	D	I	A	E	P	G	S	A	A	V	I	D	F	M	T	V	R	E	R	G	S	V	Q	H	L	G	S	T	I	R	A	R	L	D	P	S	S	D	R	M	A	A	L	E	A	L	F	P	A	V
Secondary structure
SS confidence
Disorder																									?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		T	A	S	G	I	P	K	A	A	G	V	E	A	I	F	R	L	D	E	C	P	R	G	L	Y	S	G	A	V	V	M	L	S	A	D	G	G	L	D	A	A	L	T	L	R	A	A	Y	Q	V	G	G	R	T	W	L	R	A	G	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450
Sequence		G	I	I	E	E	S	E	P	E	R	E	F	E	E	T	C	E	K	L	S	T	L	T	P	Y	L	V	A	R	Q
Secondary structure
SS confidence
Disorder																											?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 31%) Beta strand ( 32%)

Rank Aligned region

PDB 2g5f chain A domain 1 Region: 15 - 449 Aligned: 435 Modelled: 435 Confidence: 100.0% Identity: 100% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 2i6y chain A Region: 17 - 449 Aligned: 419 Modelled: 433 Confidence: 100.0% Identity: 100% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i, putative; PDBTitle: structure and mechanism of mycobacterium tuberculosis salicylate2 synthase, mbti Phyre2 PDB 4pen chain A Region: 15 - 446 Aligned: 424 Modelled: 432 Confidence: 100.0% Identity: 26% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component 1; PDBTitle: structure of anthranilate synthase component i (trpe) from2 mycobacterium tuberculosis with inhibitor bound Phyre2 PDB 1qdl chain A Region: 15 - 446 Aligned: 403 Modelled: 414 Confidence: 100.0% Identity: 27% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1i1q chain A Region: 17 - 446 Aligned: 429 Modelled: 430 Confidence: 100.0% Identity: 24% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1i7q chain A Region: 17 - 446 Aligned: 429 Modelled: 430 Confidence: 100.0% Identity: 22% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 2fn0 chain A domain 1 Region: 20 - 447 Aligned: 405 Modelled: 408 Confidence: 100.0% Identity: 37% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 5kck chain A Region: 24 - 444 Aligned: 400 Modelled: 415 Confidence: 100.0% Identity: 27% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i; PDBTitle: crystal structure of anthranilate synthase component i from2 streptococcus pneumoniae tigr4 Phyre2 PDB 4grh chain A Region: 12 - 446 Aligned: 412 Modelled: 421 Confidence: 100.0% Identity: 28% PDB header:transferase Chain: A: PDB Molecule:aminodeoxychorismate synthase; PDBTitle: crystal structure of pabb of stenotrophomonas maltophilia Phyre2 PDB 3bzn chain A domain 1 Region: 7 - 446 Aligned: 392 Modelled: 403 Confidence: 100.0% Identity: 22% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1k0g chain A Region: 11 - 446 Aligned: 401 Modelled: 401 Confidence: 100.0% Identity: 19% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3h9m chain A Region: 21 - 446 Aligned: 381 Modelled: 391 Confidence: 100.0% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:p-aminobenzoate synthetase, component i; PDBTitle: crystal structure of para-aminobenzoate synthetase, component i from2 cytophaga hutchinsonii Phyre2 PDB 3hwo chain B Region: 46 - 446 Aligned: 365 Modelled: 375 Confidence: 100.0% Identity: 22% PDB header:isomerase Chain: B: PDB Molecule:isochorismate synthase entc; PDBTitle: crystal structure of escherichia coli enterobactin-specific2 isochorismate synthase entc in complex with isochorismate Phyre2 PDB 3gse chain A Region: 1 - 442 Aligned: 396 Modelled: 420 Confidence: 100.0% Identity: 20% PDB header:isomerase Chain: A: PDB Molecule:menaquinone-specific isochorismate synthase; PDBTitle: crystal structure of menaquinone-specific isochorismate synthase from2 yersinia pestis co92 Phyre2 PDB 3os6 chain A Region: 35 - 446 Aligned: 358 Modelled: 360 Confidence: 100.0% Identity: 23% PDB header:isomerase Chain: A: PDB Molecule:isochorismate synthase dhbc; PDBTitle: crystal structure of putative 2,3-dihydroxybenzoate-specific2 isochorismate synthase, dhbc from bacillus anthracis. Phyre2 PDB 3r74 chain B Region: 119 - 450 Aligned: 326 Modelled: 332 Confidence: 100.0% Identity: 19% PDB header:lyase, biosynthetic protein Chain: B: PDB Molecule:anthranilate/para-aminobenzoate synthases component i; PDBTitle: crystal structure of 2-amino-2-desoxyisochorismate synthase (adic)2 synthase phze from burkholderia lata 383 Phyre2 PDB 3nqk chain A Region: 383 - 419 Aligned: 37 Modelled: 37 Confidence: 40.1% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a structural genomics, unknown function2 (bacova_03322) from bacteroides ovatus at 2.61 a resolution Phyre2 PDB 1cvr chain A domain 1 Region: 385 - 427 Aligned: 38 Modelled: 43 Confidence: 39.1% Identity: 29% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Gingipain R (RgpB), C-terminal domain Phyre2 PDB 2km1 chain A Region: 352 - 374 Aligned: 23 Modelled: 23 Confidence: 25.2% Identity: 22% PDB header:protein binding Chain: A: PDB Molecule:protein dre2; PDBTitle: solution structure of the n-terminal domain of the yeast protein dre2 Phyre2 PDB 2ffc chain A domain 1 Region: 360 - 446 Aligned: 82 Modelled: 87 Confidence: 21.5% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Decarboxylase Phyre2 1 d2g5fa1 2 c2i6yA_ 3 c4penA_ 4 d1qdla_ 5 d1i1qa_ 6 d1i7qa_ 7 d2fn0a1 8 c5kckA_ 9 c4grhA_ 10 d3bzna1 11 d1k0ga_ 12 c3h9mA_ 13 c3hwoB_ 14 c3gseA_ 15 c3os6A_ 16 c3r74B_ 17 c3nqkA_ 18 d1cvra1 19 c2km1A_ 20 d2ffca1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66