1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	H	E	F	W	V	N	F	T	H	N	L	F	K	P	L	L	L	F	F	Y	F	G	F	L	I	P	I	F	K	V	R	F	E	F	P	Y	V	L	Y	Q	G	L	T	L	Y	L	L	L	A	I	G	W	H	G	G	E	E	L
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	K	I	K	P	S	N	V	G	A	I	V	G	F	M	V	V	G	F	A	L	N	F	V	I	G	T	L	A	Y	F	L	L	S	K	L	T	A	M	R	R	V	D	R	A	T	V	A	G	Y	Y	G	S	D	S	A	G	T	F	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																															?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	C	V	A	V	L	T	S	V	G	M	A	F	D	A	Y	M	P	V	M	L	A	V	M	E	I	P	G	C	L	V	A	L	Y	L	V	A	R	L	R	H	R	G	M	N	E	A	G	Y	M	A	D	E	P	G	Y	T	T	A	A
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?																									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		M	I	G	A	G	P	G	T	P	A	R	P	A	H	S	D	S	L	T	A	Q	A	E	R	G	I	E	E	E	L	E	L	S	L	E	K	R	E	H	P	N	W	D	E	D	G	V	K	D	S	G	T	N	A	S	I	F	S	R	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?											?	?	?	?	?	?	?	?	?	?															?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	L	Q	E	V	F	L	N	P	G	L	V	L	L	F	G	G	I	V	I	G	L	I	S	G	L	Q	G	Q	K	V	L	H	D	D	D	N	F	F	V	A	A	F	Q	G	V	L	C	L	F	L	L	E	M	G	M	T	A	S	R
Secondary structure
SS confidence
Disorder																												?		?	?	?	?	?		?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	L	K	D	L	A	S	A	G	S	G	F	V	F	F	G	L	L	A	P	N	L	F	A	T	L	G	I	I	V	A	H	G	Y	A	Y	V	T	N	N	D	F	A	P	G	T	Y	V	L	F	A	V	L	C	G	A	A	S	Y	I
Secondary structure
SS confidence
Disorder			?																																			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.
Sequence		A	V	P	A	V	Q	R	L	A	I	P	E	A	S	P	T	L	P	L	A	A	S	L	G	L	T	F	S	Y	N	V	T	I	G	I	P	L	Y	I	E	I	A	R	I	V	G	Q	W	F	P	A	T	G	A	S	I	G
Secondary structure
SS confidence
Disorder																	?	?																																		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 78%) Beta strand ( 0%) TM helix ( 52%) (View membrane topology prediction)

Rank Aligned region

PDB 4cz8 chain A Region: 239 - 393 Aligned: 145 Modelled: 154 Confidence: 55.4% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:na+/h+ antiporter, putative; PDBTitle: structure of the sodium proton antiporter panhap from2 pyrococcus abyssii at ph 8. Phyre2 PDB 4bwz chain A Region: 254 - 406 Aligned: 141 Modelled: 153 Confidence: 55.1% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:na(+)/h(+) antiporter; PDBTitle: crystal structure of the sodium proton antiporter, napa Phyre2 PDB 5bz3 chain A Region: 254 - 406 Aligned: 141 Modelled: 153 Confidence: 55.1% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:na(+)/h(+) antiporter; PDBTitle: crystal structure of sodium proton antiporter napa in outward-facing2 conformation. Phyre2 PDB 1kpl chain A Region: 3 - 163 Aligned: 125 Modelled: 145 Confidence: 44.7% Identity: 22% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 4czb chain B Region: 238 - 412 Aligned: 163 Modelled: 175 Confidence: 41.9% Identity: 17% PDB header:membrane protein Chain: B: PDB Molecule:na(+)/h(+) antiporter 1; PDBTitle: structure of the sodium proton antiporter mjnhap1 from2 methanocaldococcus jannaschii at ph 8. Phyre2 PDB 2bgw chain A domain 1 Region: 88 - 132 Aligned: 45 Modelled: 45 Confidence: 36.0% Identity: 13% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 2ht2 chain B Region: 3 - 163 Aligned: 125 Modelled: 133 Confidence: 30.8% Identity: 22% PDB header:membrane protein Chain: B: PDB Molecule:h(+)/cl(-) exchange transporter clca; PDBTitle: structure of the escherichia coli clc chloride channel2 y445h mutant and fab complex Phyre2 PDB 2mut chain A Region: 90 - 131 Aligned: 42 Modelled: 42 Confidence: 28.3% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:dna excision repair protein ercc-1; PDBTitle: solution structure of the f231l mutant ercc1-xpf dimerization region Phyre2 PDB 2a1j chain B domain 1 Region: 92 - 131 Aligned: 40 Modelled: 40 Confidence: 27.7% Identity: 18% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 6hu9 chain R Region: 292 - 312 Aligned: 21 Modelled: 21 Confidence: 26.7% Identity: 33% PDB header:oxidoreductase/electron transport Chain: R: PDB Molecule:cytochrome b-c1 complex subunit 7; PDBTitle: iii2-iv2 mitochondrial respiratory supercomplex from s. cerevisiae Phyre2 PDB 6gct chain A Region: 239 - 345 Aligned: 107 Modelled: 107 Confidence: 26.1% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:neutral amino acid transporter b(0); PDBTitle: cryo-em structure of the human neutral amino acid transporter asct2 Phyre2 PDB 1x2i chain A domain 1 Region: 91 - 131 Aligned: 41 Modelled: 41 Confidence: 25.6% Identity: 12% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 1v54 chain E Region: 292 - 312 Aligned: 21 Modelled: 21 Confidence: 25.5% Identity: 33% Fold: alpha-alpha superhelix Superfamily: Cytochrome c oxidase subunit E Family: Cytochrome c oxidase subunit E Phyre2 PDB 2y69 chain R Region: 292 - 312 Aligned: 21 Modelled: 21 Confidence: 25.3% Identity: 33% PDB header:electron transport Chain: R: PDB Molecule:cytochrome c oxidase subunit 5a; PDBTitle: bovine heart cytochrome c oxidase re-refined with molecular oxygen Phyre2 PDB 1ots chain A Region: 3 - 163 Aligned: 125 Modelled: 145 Confidence: 23.6% Identity: 22% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 5a40 chain C Region: 13 - 98 Aligned: 80 Modelled: 86 Confidence: 23.4% Identity: 16% PDB header:transport protein Chain: C: PDB Molecule:putative fluoride ion transporter crcb; PDBTitle: crystal structure of a dual topology fluoride ion channel. Phyre2 PDB 2fym chain A domain 2 Region: 379 - 406 Aligned: 28 Modelled: 28 Confidence: 17.7% Identity: 39% Fold: Enolase N-terminal domain-like Superfamily: Enolase N-terminal domain-like Family: Enolase N-terminal domain-like Phyre2 PDB 3c1z chain A Region: 89 - 116 Aligned: 28 Modelled: 28 Confidence: 16.8% Identity: 14% PDB header:dna binding protein Chain: A: PDB Molecule:dna integrity scanning protein disa; PDBTitle: structure of the ligand-free form of a bacterial dna damage sensor2 protein Phyre2 PDB 2al1 chain A domain 2 Region: 379 - 406 Aligned: 28 Modelled: 28 Confidence: 14.1% Identity: 25% Fold: Enolase N-terminal domain-like Superfamily: Enolase N-terminal domain-like Family: Enolase N-terminal domain-like Phyre2 PDB 2lyh chain A Region: 90 - 130 Aligned: 41 Modelled: 41 Confidence: 13.3% Identity: 12% PDB header:dna binding protein Chain: A: PDB Molecule:fanconi anemia-associated protein of 24 kda; PDBTitle: structure of faap24 residues 141-215 Phyre2 1 c4cz8A_ 2 c4bwzA_ 3 c5bz3A_ 4 d1kpla_ 5 c4czbB_ 6 d2bgwa1 7 c2ht2B_ 8 c2mutA_ 9 d2a1jb1 10 c6hu9r_ 11 c6gctA_ 12 d1x2ia1 13 d1v54e_ 14 c2y69R_ 15 d1otsa_ 16 c5a40C_ 17 d2fyma2 18 c3c1zA_ 19 d2al1a2 20 c2lyhA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48