1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	K	E	N	P	Q	M	T	T	A	R	P	A	K	A	R	N	E	G	Q	W	A	L	G	H	R	E	P	L	N	A	N	E	E	L	K	K	A	G	N	P	L	D	V	R	E	R	I	E	N	I	Y	A	K	Q	G	F	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	I	D	K	T	D	L	R	G	R	F	R	W	W	G	L	Y	T	Q	R	E	Q	G	Y	D	G	T	W	T	G	D	D	N	I	D	K	L	E	A	K	Y	F	M	M	R	V	R	C	D	G	G	A	L	S	A	A	A	L	R	T
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	G	Q	I	S	T	E	F	A	R	D	T	A	D	I	S	D	R	Q	N	V	Q	Y	H	W	I	E	V	E	N	V	P	E	I	W	R	R	L	D	D	V	G	L	Q	T	T	E	A	C	G	D	C	P	R	V	V	L	G	S	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	A	G	E	S	L	D	E	V	L	D	P	T	W	A	I	E	E	I	V	R	R	Y	I	G	K	P	D	F	A	D	L	P	R	K	Y	K	T	A	I	S	G	L	Q	D	V	A	H	E	I	N	D	V	A	F	I	G	V	N	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	E	H	G	P	G	L	D	L	W	V	G	G	G	L	S	T	N	P	M	L	A	Q	R	V	G	A	W	V	P	L	G	E	V	P	E	V	W	A	A	V	T	S	V	F	R	D	Y	G	Y	R	R	L	R	A	K	A	R	L	K
Secondary structure
SS confidence
Disorder																																																			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		F	L	I	K	D	W	G	I	A	K	F	R	E	V	L	E	T	E	Y	L	K	R	P	L	I	D	G	P	A	P	E	P	V	K	H	P	I	D	H	V	G	V	Q	R	L	K	N	G	L	N	A	V	G	V	A	P	I	A	G	R
Secondary structure
SS confidence
Disorder																											?													?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	S	G	T	I	L	T	A	V	A	D	L	M	A	R	A	G	S	D	R	I	R	F	T	P	Y	Q	K	L	V	I	L	D	I	P	D	A	L	L	D	D	L	I	A	G	L	D	A	L	G	L	Q	S	R	P	S	H	W	R	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		N	L	M	A	C	S	G	I	E	F	C	K	L	S	F	A	E	T	R	V	R	A	Q	H	L	V	P	E	L	E	R	R	L	E	D	I	N	S	Q	L	D	V	P	I	T	V	N	I	N	G	C	P	N	S	C	A	R	I	Q	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		A	D	I	G	F	K	G	Q	M	I	D	D	G	H	G	G	S	V	E	G	F	Q	V	H	L	G	G	H	L	G	L	D	A	G	F	G	R	K	L	R	Q	H	K	V	T	S	D	E	L	G	D	Y	I	D	R	V	V	R	N	F
Secondary structure
SS confidence
Disorder																																?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.
Sequence		V	K	H	R	S	E	G	E	R	F	A	Q	W	V	I	R	A	E	E	D	D	L	R
Secondary structure
SS confidence
Disorder						?	?																?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 38%) Beta strand ( 15%)

Rank Aligned region

PDB 1zj8 chain B Region: 18 - 563 Aligned: 546 Modelled: 546 Confidence: 100.0% Identity: 100% PDB header:oxidoreductase Chain: B: PDB Molecule:probable ferredoxin-dependent nitrite reductase nira; PDBTitle: structure of mycobacterium tuberculosis nira protein Phyre2 PDB 5h92 chain A Region: 30 - 563 Aligned: 505 Modelled: 532 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase/electron transport Chain: A: PDB Molecule:sulfite reductase [ferredoxin], chloroplastic; PDBTitle: crystal structure of the complex between maize sulfite reductase and2 ferredoxin in the form-3 crystal Phyre2 PDB 3b0n chain A Region: 13 - 545 Aligned: 510 Modelled: 518 Confidence: 100.0% Identity: 32% PDB header:oxidoreductase Chain: A: PDB Molecule:nitrite reductase; PDBTitle: q448k mutant of assimilatory nitrite reductase (nii3) from tobbaco2 leaf Phyre2 PDB 2akj chain A Region: 12 - 545 Aligned: 511 Modelled: 519 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:ferredoxin--nitrite reductase, chloroplast; PDBTitle: structure of spinach nitrite reductase Phyre2 PDB 5aop chain A Region: 103 - 561 Aligned: 433 Modelled: 459 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:sulfite reductase hemoprotein; PDBTitle: sulfite reductase structure reduced with crii edta, 5-coordinate2 siroheme, siroheme feii, [4fe-4s] +1 Phyre2 PDB 2v4j chain A Region: 3 - 345 Aligned: 315 Modelled: 343 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:sulfite reductase, dissimilatory-type subunit PDBTitle: the crystal structure of desulfovibrio vulgaris2 dissimilatory sulfite reductase bound to dsrc provides3 novel insights into the mechanism of sulfate respiration Phyre2 PDB 2v4j chain E Region: 60 - 342 Aligned: 270 Modelled: 283 Confidence: 100.0% Identity: 14% PDB header:oxidoreductase Chain: E: PDB Molecule:sulfite reductase, dissimilatory-type subunit PDBTitle: the crystal structure of desulfovibrio vulgaris2 dissimilatory sulfite reductase bound to dsrc provides3 novel insights into the mechanism of sulfate respiration Phyre2 PDB 3c7b chain E Region: 35 - 342 Aligned: 284 Modelled: 294 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: E: PDB Molecule:sulfite reductase, dissimilatory-type subunit beta; PDBTitle: structure of the dissimilatory sulfite reductase from archaeoglobus2 fulgidus Phyre2 PDB 1zj8 chain A domain 2 Region: 18 - 169 Aligned: 152 Modelled: 152 Confidence: 100.0% Identity: 100% Fold: Ferredoxin-like Superfamily: Nitrite/Sulfite reductase N-terminal domain-like Family: Duplicated SiR/NiR-like domains 1 and 3 Phyre2 PDB 3c7b chain A Region: 33 - 333 Aligned: 287 Modelled: 301 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:sulfite reductase, dissimilatory-type subunit alpha; PDBTitle: structure of the dissimilatory sulfite reductase from archaeoglobus2 fulgidus Phyre2 PDB 1zj8 chain A domain 4 Region: 170 - 334 Aligned: 165 Modelled: 165 Confidence: 100.0% Identity: 100% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 1aop chain A domain 3 Region: 170 - 339 Aligned: 163 Modelled: 170 Confidence: 100.0% Identity: 25% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 2akj chain A domain 4 Region: 171 - 334 Aligned: 163 Modelled: 164 Confidence: 100.0% Identity: 31% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 2akj chain A domain 2 Region: 13 - 169 Aligned: 141 Modelled: 142 Confidence: 100.0% Identity: 30% Fold: Ferredoxin-like Superfamily: Nitrite/Sulfite reductase N-terminal domain-like Family: Duplicated SiR/NiR-like domains 1 and 3 Phyre2 PDB 1zj8 chain A domain 3 Region: 415 - 563 Aligned: 149 Modelled: 149 Confidence: 100.0% Identity: 100% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 1aop chain A domain 4 Region: 417 - 561 Aligned: 134 Modelled: 145 Confidence: 100.0% Identity: 25% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 3c7b chain B domain 3 Region: 419 - 563 Aligned: 134 Modelled: 145 Confidence: 100.0% Identity: 17% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 2v4j chain B domain 3 Region: 416 - 563 Aligned: 139 Modelled: 148 Confidence: 100.0% Identity: 17% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 3c7b chain A domain 3 Region: 172 - 331 Aligned: 151 Modelled: 160 Confidence: 100.0% Identity: 20% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 2akj chain A domain 3 Region: 415 - 545 Aligned: 125 Modelled: 131 Confidence: 100.0% Identity: 34% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 1 c1zj8B_ 2 c5h92A_ 3 c3b0nA_ 4 c2akjA_ 5 c5aopA_ 6 c2v4jA_ 7 c2v4jE_ 8 c3c7bE_ 9 d1zj8a2 10 c3c7bA_ 11 d1zj8a4 12 d1aopa3 13 d2akja4 14 d2akja2 15 d1zj8a3 16 d1aopa4 17 d3c7bb3 18 d2v4jb3 19 d3c7ba3 20 d2akja3 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111